2024
Automated Identification of Heart Failure With Reduced Ejection Fraction Using Deep Learning-Based Natural Language Processing
Nargesi A, Adejumo P, Dhingra L, Rosand B, Hengartner A, Coppi A, Benigeri S, Sen S, Ahmad T, Nadkarni G, Lin Z, Ahmad F, Krumholz H, Khera R. Automated Identification of Heart Failure With Reduced Ejection Fraction Using Deep Learning-Based Natural Language Processing. JACC Heart Failure 2024 PMID: 39453355, DOI: 10.1016/j.jchf.2024.08.012.Peer-Reviewed Original ResearchReduced ejection fractionEjection fractionHeart failureLeft ventricular ejection fractionVentricular ejection fractionYale-New Haven HospitalIdentification of patientsCommunity hospitalIdentification of heart failureLanguage modelNorthwestern MedicineMeasure care qualityQuality of careNew Haven HospitalDeep learning-based natural language processingHFrEFGuideline-directed careDeep learning language modelsMIMIC-IIIDetect HFrEFNatural language processingReclassification improvementHospital dischargePatientsCare quality
2023
Detection of Left Ventricular Systolic Dysfunction From Electrocardiographic Images
Sangha V, Nargesi A, Dhingra L, Khunte A, Mortazavi B, Ribeiro A, Banina E, Adeola O, Garg N, Brandt C, Miller E, Ribeiro A, Velazquez E, Giatti L, Barreto S, Foppa M, Yuan N, Ouyang D, Krumholz H, Khera R. Detection of Left Ventricular Systolic Dysfunction From Electrocardiographic Images. Circulation 2023, 148: 765-777. PMID: 37489538, PMCID: PMC10982757, DOI: 10.1161/circulationaha.122.062646.Peer-Reviewed Original ResearchConceptsLV systolic dysfunctionYale-New Haven HospitalVentricular systolic dysfunctionSystolic dysfunctionLV ejection fractionBrazilian Longitudinal StudyNew Haven HospitalEjection fractionCardiology clinicRegional hospitalLeft ventricular systolic dysfunctionCedars-Sinai Medical CenterAdult Health (ELSA-Brasil) cohort
2020
Evaluation of Case Volumes of a Heart Transplant Program and Short-term Outcomes After Changes in the United Network for Organ Sharing Donor Heart Allocation System
Mori M, Wilson L, Ali A, Ahmad T, Anwer M, Jacoby D, Geirsson A, Krumholz HM. Evaluation of Case Volumes of a Heart Transplant Program and Short-term Outcomes After Changes in the United Network for Organ Sharing Donor Heart Allocation System. JAMA Network Open 2020, 3: e2017513. PMID: 32945877, PMCID: PMC7501535, DOI: 10.1001/jamanetworkopen.2020.17513.Peer-Reviewed Original ResearchConceptsYale-New Haven HospitalHeart transplant programShort-term outcomesHeart transplantHeart transplant volumeNew Haven HospitalDonor heartsPatient selectionRecipient selectionTransplant programsTransplant volumeWaiting listCase volumeDonor heart allocation systemPre-post cohort studyConservative patient selectionUnused donor heartsHeart allocation systemHigher median numberCirculatory assist devicesCohort studyPatient characteristicsMore patientsSingle centerCenter volume
2017
Prediction of Adverse Events in Patients Undergoing Major Cardiovascular Procedures
Mortazavi B, Desai N, Zhang J, Coppi A, Warner F, Krumholz H, Negahban S. Prediction of Adverse Events in Patients Undergoing Major Cardiovascular Procedures. IEEE Journal Of Biomedical And Health Informatics 2017, 21: 1719-1729. PMID: 28287993, DOI: 10.1109/jbhi.2017.2675340.Peer-Reviewed Original ResearchConceptsMajor cardiovascular proceduresElectronic health recordsRespiratory failureAdverse eventsCardiovascular proceduresYale-New Haven HospitalPostoperative respiratory failurePatient cohortHospital costsPatient outcomesSpecific patientPatientsHealth recordsCohort-specific modelsCharacteristic curveInfectionFailureHospitalCohortClinicians
2006
Acute, Severe Noncardiac Conditions in Patients with Acute Myocardial Infarction
Lichtman JH, Fathi A, Radford MJ, Lin Z, Loeser CS, Krumholz HM. Acute, Severe Noncardiac Conditions in Patients with Acute Myocardial Infarction. The American Journal Of Medicine 2006, 119: 843-850. PMID: 17000215, DOI: 10.1016/j.amjmed.2006.03.040.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionNoncardiac conditionsHospital mortalityPrognostic importanceMyocardial infarctionMortality riskYale-New Haven HospitalExcessive mortality riskHospital mortality riskSubgroup of patientsSubset of patientsRisk-adjusted analysisRisk of deathMultivariable logistic modelCardiac severityInitial therapyConsecutive patientsClinical presentationMultivariable analysisMedical historyPatientsPatient recordsMortalityMarked increaseInfarctionRecursive partitioning–based preoperative risk stratification for atrial fibrillation after coronary artery bypass surgery
Sedrakyan A, Zhang H, Treasure T, Krumholz HM. Recursive partitioning–based preoperative risk stratification for atrial fibrillation after coronary artery bypass surgery. American Heart Journal 2006, 151: 720-724. PMID: 16504639, DOI: 10.1016/j.ahj.2005.05.010.Peer-Reviewed Original ResearchConceptsCoronary artery bypass graft surgeryAtrial fibrillationLow-risk groupAggressive prophylaxisRelative riskPredictors of AFArtery bypass graft surgeryCoronary artery bypass surgeryRisk of AFYale-New Haven HospitalOnly ejection fractionPreoperative atrial fibrillationBypass graft surgeryArtery bypass surgeryCoronary artery diseasePreoperative risk stratificationHigh-risk groupHeart disease severityPossible adverse eventsOlder age subgroupsArrhythmia prophylaxisGraft surgeryProphylactic therapyAdverse eventsBypass surgery
2004
Quality of life after aortic valve replacement with tissue and mechanical implants
Sedrakyan A, Hebert P, Vaccarino V, Paltiel AD, Elefteriades JA, Mattera J, Lin Z, Roumanis SA, Krumholz HM. Quality of life after aortic valve replacement with tissue and mechanical implants. Journal Of Thoracic And Cardiovascular Surgery 2004, 128: 266-272. PMID: 15282464, DOI: 10.1016/j.jtcvs.2003.12.014.Peer-Reviewed Original ResearchConceptsAortic valve replacementQuality of lifeMechanical valve implantsMechanical valve recipientsValve replacementValve recipientsLife scoresValve implantsTissue valvesMechanical valvesMedical Outcomes Trust Short FormPopulation normsYale-New Haven HospitalMechanical valve replacementRate of complicationsUS population normsTissue valve replacementPrognostic factorsRole limitationsOnly significant differenceHealth SurveyAnalysis of covarianceBaseline qualityMean qualityPatients
1999
Gender differences in symptom presentation associated with coronary heart disease
Milner K, Funk M, Richards S, Wilmes R, Vaccarino V, Krumholz H. Gender differences in symptom presentation associated with coronary heart disease. The American Journal Of Cardiology 1999, 84: 396-399. PMID: 10468075, DOI: 10.1016/s0002-9149(99)00322-7.Peer-Reviewed Original ResearchConceptsCoronary heart diseaseNon-chest pain symptomsChest painEmergency departmentPain symptomsUnadjusted analysesHeart diseaseSymptom presentationYale-New Haven HospitalSubgroup of patientsNurse data collectorsGender differencesMidback painProspective studyPainNauseaVomitingSymptomsPatientsWomenDyspneaSignificant gender differencesMenDiseaseIndigestion
1998
Trends in costs of percutaneous transluminal coronary angioplasty.
Heiat A, Mattera JA, Henry GA, Chen YT, Krumholz HM. Trends in costs of percutaneous transluminal coronary angioplasty. The American Journal Of Managed Care 1998, 4: 1667-74. PMID: 10339099.Peer-Reviewed Original ResearchConceptsPercutaneous transluminal coronary angioplastyTransluminal coronary angioplastyCoronary angioplastyClinical outcomesElective percutaneous transluminal coronary angioplastyYale-New Haven HospitalCatheterization laboratory costsMedical chart reviewGroup of patientsTotal hospital costsLength of stayHospital cost accounting systemChart reviewClinical characteristicsConsecutive patientsAngiographic featuresHospital recordsContrast volumeRetrospective studyPatient populationHospital costsLesion characteristicsStent useCatheterization laboratoryPatient profiles
1995
Outcomes after major vascular surgery: The patients' perspective
Lacey K, Meier G, Krumholz H, Gusberg R. Outcomes after major vascular surgery: The patients' perspective. Journal Of Vascular Nursing 1995, 13: 8-13. PMID: 7742256, DOI: 10.1016/s1062-0303(05)80047-0.Peer-Reviewed Original ResearchConceptsQuality of lifeLong-term survivorsElderly patientsSF-36Surgical outcomesYale-New Haven HospitalBilateral renal revascularizationMinimal physical disabilityMajor vascular surgeryOutcome of surgeryVascular surgical interventionGroup of patientsHealth Status QuestionnaireIntensive care unitLong-term resultsRates of morbidityHigh-risk interventionsTraditional outcome measuresAssessment of outcomesRenal revascularizationVascular nurseHospital stayOperative morbidityPostoperative qualityCare unit