2005
Performance of the Thrombolysis in Myocardial Infarction (TIMI) ST-elevation myocardial infarction risk score in a national cohort of elderly patients
Rathore SS, Weinfurt KP, Foody JM, Krumholz HM. Performance of the Thrombolysis in Myocardial Infarction (TIMI) ST-elevation myocardial infarction risk score in a national cohort of elderly patients. American Heart Journal 2005, 150: 402-410. PMID: 16169316, PMCID: PMC2790534, DOI: 10.1016/j.ahj.2005.03.069.Peer-Reviewed Original ResearchConceptsThirty-day mortality rateTIMI scoreElderly patientsMortality rateRisk scoreMyocardial Infarction (TIMI) risk scoreHigh TIMI scoreMyocardial Infarction (TIMI) scoreCommunity-based cohortReperfusion therapyTrial cohortPrognostic discriminationTrial populationNational cohortModest discriminationPatientsUS hospitalsSTEMICohortScore discriminationScoresThrombolysis
2002
Thrombolysis for Acute Stroke in Routine Clinical Practice
Bravata DM, Kim N, Concato J, Krumholz HM, Brass LM. Thrombolysis for Acute Stroke in Routine Clinical Practice. JAMA Internal Medicine 2002, 162: 1994-2001. PMID: 12230423, DOI: 10.1001/archinte.162.17.1994.Peer-Reviewed Original ResearchConceptsMajor protocol deviationsRoutine clinical practiceConnecticut cohortProtocol deviationsHospital mortalityAcute strokeThrombolytic therapyClinical practiceExtracranial hemorrhageCommunity-based patientsMinor protocol deviationsHigh rateIntravenous thrombolysisAdverse eventsRetrospective cohortHemorrhage ratePatient outcomesConnecticut hospitalsPatientsThrombolysisNeurological disordersCohortExperienced cliniciansStudy settingTherapy
2000
Factors associated with delay in reperfusion therapy in elderly patients with acute myocardial infarction: Analysis of the Cooperative Cardiovascular Project
Berger A, Radford M, Krumholz H. Factors associated with delay in reperfusion therapy in elderly patients with acute myocardial infarction: Analysis of the Cooperative Cardiovascular Project. American Heart Journal 2000, 139: 985-992. PMID: 10827378, DOI: 10.1067/mhj.2000.105703.Peer-Reviewed Original ResearchMeSH KeywordsAgedAnistreplaseElectrocardiographyFemaleHumansMaleMyocardial InfarctionPatient AdmissionPlasminogen ActivatorsQuality Indicators, Health CareRetrospective StudiesRisk FactorsStreptokinaseSurvival RateThrombolytic TherapyTime FactorsTissue Plasminogen ActivatorTreatment FailureUnited StatesConceptsAcute myocardial infarctionHospital arrivalElderly patientsMortality rateMyocardial infarctionCardiology/American Heart Association guidelinesAmerican Heart Association guidelinesAdministration of thrombolysisHistory of hypertensionHeart Association guidelinesCooperative Cardiovascular Project databaseCooperative Cardiovascular ProjectCardiac catheterization laboratoryReperfusion therapyClinical characteristicsHeart failureST elevationThrombolytic therapyAssociation guidelinesHospital characteristicsCatheterization laboratoryAmerican CollegeThrombolysisPatientsRapid treatment
1991
Reperfusion arrhythmias after thrombolysis. Electrophysiologic tempest, or much ado about nothing.
Krumholz HM, Goldberger AL. Reperfusion arrhythmias after thrombolysis. Electrophysiologic tempest, or much ado about nothing. CHEST Journal 1991, 99: 135s-140s. PMID: 2009810, DOI: 10.1378/chest.99.4.135s.Peer-Reviewed Original ResearchConceptsThrombolytic therapyMyocardial infarctionAcute myocardial infarctionSignificant clinical interestReperfusion arrhythmiasSuccessful reperfusionMyocardial reperfusionIdioventricular rhythmClinical eventsVentricular tachyarrhythmiasNoninvasive markerAnimal studiesArrhythmiasConsistent markerReperfusionClinical interestInfarctionTherapyCurrent dataMarkersThrombolysisTachyarrhythmias