2005
The Relationship Between B-type Natriuretic Peptide and Health Status in Patients With Heart Failure
Luther SA, McCullough PA, Havranek EP, Rumsfeld JS, Jones PG, Heidenreich PA, Peterson ED, Rathore SS, Krumholz HM, Weintraub WS, Spertus JA, Masoudi FA, Consortium F. The Relationship Between B-type Natriuretic Peptide and Health Status in Patients With Heart Failure. Journal Of Cardiac Failure 2005, 11: 414-421. PMID: 16105631, DOI: 10.1016/j.cardfail.2005.02.004.Peer-Reviewed Original ResearchConceptsKansas City Cardiomyopathy QuestionnaireBNP levelsHeart failureHealth statusBNP changesB-type natriuretic peptide levelsNew York Heart Association classificationB-type natriuretic peptideBaseline BNP levelsKCCQ summary scoreNatriuretic peptide levelsHeart failure severitySystolic heart failureHealth status instrumentsBaseline BNPKCCQ scoresNatriuretic peptideAssociation classificationPatients' perceptionsPeptide levelsPhysiologic measuresSummary scoresPatientsBNPDisease severity
2004
Renal Function, Digoxin Therapy, and Heart Failure Outcomes: Evidence from the Digoxin Intervention Group Trial
SHLIPAK MG, SMITH GL, RATHORE SS, MASSIE BM, KRUMHOLZ HM. Renal Function, Digoxin Therapy, and Heart Failure Outcomes: Evidence from the Digoxin Intervention Group Trial. Journal Of The American Society Of Nephrology 2004, 15: 2195-2203. PMID: 15284305, DOI: 10.1097/01.asn.0000135121.81744.75.Peer-Reviewed Original ResearchConceptsGlomerular filtration rateHeart failure outcomesEffect of digoxinRenal functionHeart failureRenal dysfunctionGroup trialsMortality riskLow glomerular filtration rateLevel of GFRFailure outcomesSystolic heart failureHeart failure survivalLower mortality hazardDigoxin efficacyCause mortalityDigoxin therapyCommon complicationClinical outcomesFiltration rateGFR 60Failure survivalSimilar riskMortality hazardStable outpatients