2023
Safety and Efficacy of Inferior Vena Cava Filters in Patients at Risk of Pulmonary Embolism: A Systematic Review and Meta-Analysis
Rashedi S, Bejjani A, Khairani C, Lou J, Chatterjee S, Jiménez D, Gerhard-Herman M, Mena-Hurtado C, Goldhaber S, Piazza G, Krumholz H, Sadeghipour P, Bikdeli B. Safety and Efficacy of Inferior Vena Cava Filters in Patients at Risk of Pulmonary Embolism: A Systematic Review and Meta-Analysis. Cardiovascular Revascularization Medicine 2023, 53: s66-s67. DOI: 10.1016/j.carrev.2023.05.150.Peer-Reviewed Original ResearchCRT-300.15 Safety and Efficacy of Inferior Vena Cava Filters in Patients at Risk of Pulmonary Embolism: A Systematic Review and Meta-Analysis
Rashedi S, Bejjani A, Khairani C, Lou J, Chatterjee S, Jiménez D, Gerhard-Herman M, Mena-Hurtado C, Goldhaber S, Piazza G, Krumholz H, Sadeghipour P, Bikdeli B. CRT-300.15 Safety and Efficacy of Inferior Vena Cava Filters in Patients at Risk of Pulmonary Embolism: A Systematic Review and Meta-Analysis. JACC Cardiovascular Interventions 2023, 16: s53. DOI: 10.1016/j.jcin.2023.01.172.Peer-Reviewed Original Research
2020
Updating insights into rosiglitazone and cardiovascular risk through shared data: individual patient and summary level meta-analyses
Wallach JD, Wang K, Zhang AD, Cheng D, Grossetta Nardini HK, Lin H, Bracken MB, Desai M, Krumholz HM, Ross JS. Updating insights into rosiglitazone and cardiovascular risk through shared data: individual patient and summary level meta-analyses. The BMJ 2020, 368: l7078. PMID: 32024657, PMCID: PMC7190063, DOI: 10.1136/bmj.l7078.Peer-Reviewed Original ResearchConceptsIndividual patient-level dataCardiovascular related deathsCardiovascular riskMyocardial infarctionRelated deathsSummary-level dataHeart failureOdds ratioSystematic reviewIncreased cardiovascular riskMore myocardial infarctionsHeart failure eventsCochrane Central RegistryAcute myocardial infarctionMyocardial infarction eventsPatient-level dataRandom-effects modelWeb of ScienceAnalysis of trialsEligible trialsComposite outcomeAdverse eventsContinuity correctionControlled TrialsRosiglitazone treatment
2019
Characterizing Patient‐Centered Postoperative Recovery After Adult Cardiac Surgery: A Systematic Review
Mori M, Angraal S, Chaudhry SI, Suter LG, Geirsson A, Wallach JD, Krumholz HM. Characterizing Patient‐Centered Postoperative Recovery After Adult Cardiac Surgery: A Systematic Review. Journal Of The American Heart Association 2019, 8: e013546. PMID: 31617435, PMCID: PMC6898802, DOI: 10.1161/jaha.119.013546.Peer-Reviewed Original ResearchConceptsPatient-reported outcome measuresPostoperative patient-reported outcome measuresAdult cardiac surgeryPostoperative recoveryOutcome measuresCardiac surgerySystematic reviewCoronary artery bypass graftSingle-center settingArtery bypass graftQuality of evidenceWeb of ScienceNociceptive symptomsDiversity of patientsLess comorbidityAdult patientsBypass graftPhysical functionPostacute careElective casesInclusion criteriaDaily livingPatientsStudy participantsCognitive functionCARDIOVASCULAR EVENTS IN PATIENTS RECEIVING SULODEXIDE VERSUS CONTROL: SYSTEMATIC REVIEW AND META-ANALYSIS OF RANDOMIZED CONTROLLED TRIALS
Bikdeli B, Chatterjee S, Kirtane A, Parikh S, Andreozzi G, Gibson C, Goldhaber S, Eikelboom J, Krumholz H, Stone G. CARDIOVASCULAR EVENTS IN PATIENTS RECEIVING SULODEXIDE VERSUS CONTROL: SYSTEMATIC REVIEW AND META-ANALYSIS OF RANDOMIZED CONTROLLED TRIALS. Journal Of The American College Of Cardiology 2019, 73: 144. DOI: 10.1016/s0735-1097(19)30752-1.Peer-Reviewed Original Research
2017
How well does early-career investigators' cardiovascular outcomes research training align with funded outcomes research?
Crowley MJ, Al-Khatib SM, Wang TY, Khazanie P, Kressin NR, Krumholz HM, Kiefe CI, Wells BL, O'Brien SM, Peterson ED, Sanders GD. How well does early-career investigators' cardiovascular outcomes research training align with funded outcomes research? American Heart Journal 2017, 196: 163-169. PMID: 29421009, DOI: 10.1016/j.ahj.2017.09.008.Peer-Reviewed Original ResearchConceptsOutcomes researchEarly career investigatorsCardiovascular Outcomes ResearchFunded grantsCost-effectiveness researchBlood InstituteNational HeartClinical epidemiologySystematic reviewPrior trainingCommunity-engaged researchResearch training programsDissemination researchInvestigator trainingCompetency areasObservational researchCore competency areasInvestigators' interestOutcomes researchersInvestigatorsTraining programHealth informaticsSimilar resultsLungEpidemiologyInferior Vena Cava Filters to Prevent Pulmonary Embolism Systematic Review and Meta-Analysis
Bikdeli B, Chatterjee S, Desai NR, Kirtane AJ, Desai MM, Bracken MB, Spencer FA, Monreal M, Goldhaber SZ, Krumholz HM. Inferior Vena Cava Filters to Prevent Pulmonary Embolism Systematic Review and Meta-Analysis. Journal Of The American College Of Cardiology 2017, 70: 1587-1597. PMID: 28935036, PMCID: PMC8412839, DOI: 10.1016/j.jacc.2017.07.775.Peer-Reviewed Original ResearchConceptsDeep vein thrombosisSubsequent pulmonary embolismInferior vena cava filterPulmonary embolismVena cava filtersIVC filtersCause mortalityOdds ratioCava filtersSystematic reviewSubsequent deep vein thrombosisInverse variance fixed-effect modelRisk of PECochrane Central RegisterQuality of evidenceFixed-effects modelCentral RegisterVein thrombosisControlled TrialsOverall mortalityObservational studyMAIN OUTCOMEPrimary analysisMeta-AnalysisMortalityPostapproval studies of drugs initially approved by the FDA on the basis of limited evidence: systematic review
Pease AM, Krumholz HM, Downing NS, Aminawung JA, Shah ND, Ross JS. Postapproval studies of drugs initially approved by the FDA on the basis of limited evidence: systematic review. The BMJ 2017, 357: j1680. PMID: 28468750, PMCID: PMC5421452, DOI: 10.1136/bmj.j1680.Peer-Reviewed Original ResearchConceptsSingle pivotal trialPivotal trialsPostapproval studiesSurrogate markerPrimary endpointNovel drugsClinical outcomesClinical studiesLimited evidenceSystematic reviewDouble-blind studyMedian total numberClinical evidenceSuperior efficacyBlind studyDrug AdministrationOriginal FDATrial approvalDiseaseTrialsDrugsFDAEndpointEfficacyMarkersComparison of two independent systematic reviews of trials of recombinant human bone morphogenetic protein-2 (rhBMP-2): the Yale Open Data Access Medtronic Project
Low J, Ross JS, Ritchie JD, Gross CP, Lehman R, Lin H, Fu R, Stewart LA, Krumholz HM. Comparison of two independent systematic reviews of trials of recombinant human bone morphogenetic protein-2 (rhBMP-2): the Yale Open Data Access Medtronic Project. Systematic Reviews 2017, 6: 28. PMID: 28196521, PMCID: PMC5310069, DOI: 10.1186/s13643-017-0422-x.Peer-Reviewed Original ResearchConceptsParticipant-level dataSystematic reviewSummary estimatesRecombinant human bone morphogenetic protein-2Inclusion criteriaCenter BIndividual participant-level dataMeta-analysis inclusion criteriaHuman bone morphogenetic protein-2Trial inclusion criteriaMulti-site clinical trialMain outcome measuresMost clinical outcomesStatistical methodsConcurrent systematic reviewIndependent systematic reviewsProtein 2Bone morphogenetic protein-2Summary efficacyMorphogenetic protein-2Adverse eventsClinical outcomesSurgical approachTrial inclusionClinical trialsACC/AHA Special Report: Clinical Practice Guideline Implementation Strategies: A Summary of Systematic Reviews by the NHLBI Implementation Science Work Group A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines
Chan WV, Pearson TA, Bennett GC, Cushman WC, Gaziano TA, Gorman PN, Handler J, Krumholz HM, Kushner RF, MacKenzie TD, Sacco RL, Smith SC, Stevens VJ, Wells BL. ACC/AHA Special Report: Clinical Practice Guideline Implementation Strategies: A Summary of Systematic Reviews by the NHLBI Implementation Science Work Group A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. Journal Of The American College Of Cardiology 2017, 69: 1076-1092. PMID: 28132746, DOI: 10.1016/j.jacc.2016.11.004.Peer-Reviewed Original ResearchConceptsEducational outreach visitsClinical practice guidelinesProcess of careClinical outcomesOutreach visitsPractice guidelinesSystematic reviewImplementation interventionsCardiology/American Heart Association Task ForceAmerican Heart Association Task ForceLow baseline adherenceOverweight/obesityGuideline implementation strategiesMixed effectivenessGuideline implementation interventionsCost-effectiveness outcomesProvider incentivesEvidence-based strategiesBlood pressureBlood InstituteImplementation science literatureNational HeartClinicians' knowledgeAmerican CollegeExclusion criteriaACC/AHA Special Report
Chan WV, Pearson TA, Bennett GC, Cushman WC, Gaziano TA, Gorman PN, Handler J, Krumholz HM, Kushner RF, MacKenzie TD, Sacco RL, Smith SC, Stevens VJ, Wells BL, Castillo G, Heil SK, Stephens J, Jacobson Vann J. ACC/AHA Special Report. Circulation 2017, 135: e122-e137. PMID: 28126839, DOI: 10.1161/cir.0000000000000481.Peer-Reviewed Original ResearchConceptsEducational outreach visitsClinical practice guidelinesProcess of careClinical outcomesOutreach visitsPractice guidelinesImplementation interventionsSystematic reviewLow baseline adherenceOverweight/obesityMixed effectivenessGuideline implementation interventionsCost-effectiveness outcomesProvider incentivesEvidence-based strategiesBlood pressureBlood InstituteImplementation science literatureNational HeartClinicians' knowledgeExclusion criteriaIndependent reviewersCare outcomesClinician skepticismHigher age
2012
Role of Intensive Glucose Control in Development of Renal End Points in Type 2 Diabetes Mellitus: Systematic Review and Meta-analysis
Coca SG, Ismail-Beigi F, Haq N, Krumholz HM, Parikh CR. Role of Intensive Glucose Control in Development of Renal End Points in Type 2 Diabetes Mellitus: Systematic Review and Meta-analysis. JAMA Internal Medicine 2012, 172: 761-769. PMID: 22636820, PMCID: PMC3688081, DOI: 10.1001/archinternmed.2011.2230.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedBlood GlucoseDiabetes Mellitus, Type 2Diabetic NephropathiesDisease ProgressionFemaleGlycated HemoglobinHumansHypoglycemic AgentsKidney Failure, ChronicKidney Function TestsMaleMiddle AgedMonitoring, PhysiologicPrognosisRandomized Controlled Trials as TopicRenal DialysisRisk AssessmentSeverity of Illness IndexConceptsIntensive glucose controlRenal end pointsSerum creatinine levelsConventional glucose controlGlucose controlType 2 diabetesRenal diseaseCreatinine levelsEnd pointGlycemic controlSystematic reviewType 2 diabetes mellitusAggressive glycemic controlClinical renal outcomesKidney-related outcomesIntensive glycemic controlRenal outcomesCumulative incidenceDiabetes mellitusRandomized trialsConventional therapyLanguage restrictionsMacroalbuminuriaMicroalbuminuriaType 2
2011
Promoting transparency in pharmaceutical industry-sponsored research.
Ross JS, Gross CP, Krumholz HM. Promoting transparency in pharmaceutical industry-sponsored research. American Journal Of Public Health 2011, 102: 72-80. PMID: 22095335, PMCID: PMC3319748, DOI: 10.2105/ajph.2011.300187.Commentaries, Editorials and LettersConceptsClinical trial researchTrial researchIndividual clinical decisionsGuideline recommendationsEvidence-based practiceTRIAL REGISTRATIONSystematic reviewClinical decisionInvestigator contributionsTrial outcomesMedical literaturePublic healthSelective publicationClinical trial data analysisHealthTrial data analysisIndustry-sponsored researchPatientsPhysicians
2008
Statistical Models and Patient Predictors of Readmission for Heart Failure: A Systematic Review
Ross JS, Mulvey GK, Stauffer B, Patlolla V, Bernheim SM, Keenan PS, Krumholz HM. Statistical Models and Patient Predictors of Readmission for Heart Failure: A Systematic Review. JAMA Internal Medicine 2008, 168: 1371-1386. PMID: 18625917, DOI: 10.1001/archinte.168.13.1371.Peer-Reviewed Original ResearchMeSH KeywordsDisease ProgressionEvidence-Based MedicineFemaleHeart FailureHospitalizationHumansIncidenceMaleModels, StatisticalPatient ReadmissionPredictive Value of TestsProportional Hazards ModelsQuality-Adjusted Life YearsRisk FactorsSensitivity and SpecificitySeverity of Illness IndexSurvival AnalysisUnited StatesConceptsPatient characteristicsPatient readmission riskReadmission riskPatient riskSystematic reviewReadmission ratesHospital ratesOvid Evidence-Based Medicine ReviewsEligible English-language publicationsEvidence-Based Medicine ReviewsHeart failure hospitalizationPatient risk stratificationEnglish-language literatureEnglish-language publicationsFailure hospitalizationHF hospitalizationAdult patientsHeart failureHospital readmissionMedicine ReviewsRisk stratificationPatient predictorsInclusion criteriaReadmissionCombined outcome
2007
Telemonitoring for Patients With Chronic Heart Failure: A Systematic Review
Chaudhry SI, Phillips CO, Stewart SS, Riegel B, Mattera JA, Jerant AF, Krumholz HM. Telemonitoring for Patients With Chronic Heart Failure: A Systematic Review. Journal Of Cardiac Failure 2007, 13: 56-62. PMID: 17339004, PMCID: PMC1910700, DOI: 10.1016/j.cardfail.2006.09.001.BooksConceptsHeart failure patientsFailure patientsHeart failureHigh-risk heart failure patientsHigh-risk Hispanic populationMonitoring of signsChronic heart failureHeart failure hospitalizationLow-risk patientsDisease managementHigh-quality careFailure hospitalizationNegative studiesSymptom monitoringPatientsHealth statusMEDLINE databaseSystematic reviewQuality carePhysiologic monitoringIntervention typeEvidence baseSimilar effectivenessIntervention costsHispanic population
2006
Does Random Treatment Assignment Cause Harm to Research Participants?
Gross CP, Krumholz HM, Van Wye G, Emanuel EJ, Wendler D. Does Random Treatment Assignment Cause Harm to Research Participants? PLOS Medicine 2006, 3: e188. PMID: 16719548, PMCID: PMC1470665, DOI: 10.1371/journal.pmed.0030188.Peer-Reviewed Original ResearchConceptsClinical outcomesTreatment assignmentRCT participantsClinical trialsTrial participantsRandom treatment assignmentPrimary study outcomeMeeting eligibility criteriaImproved patient outcomesSimilar health statusSubstandard medical careBaseline characteristicsPatient groupPatient outcomesEligibility criteriaHealth outcomesHealth statusEligible manuscriptsMedical careSystematic reviewSame interventionClinical researchStudy outcomesOutcomesSignificant differencesRenal Impairment and Outcomes in Heart Failure Systematic Review and Meta-Analysis
Smith GL, Lichtman JH, Bracken MB, Shlipak MG, Phillips CO, DiCapua P, Krumholz HM. Renal Impairment and Outcomes in Heart Failure Systematic Review and Meta-Analysis. Journal Of The American College Of Cardiology 2006, 47: 1987-1996. PMID: 16697315, DOI: 10.1016/j.jacc.2005.11.084.Peer-Reviewed Original ResearchConceptsRenal impairmentHF patientsSevere impairmentRenal functionExcess mortalityMortality riskSystematic reviewAssociated mortality riskHeart failure patientsCause mortality riskPrecise risk estimatesCause mortalityFailure patientsDL increaseRisk stratificationTherapeutic strategiesPatientsMeta-AnalysisMortalityRisk estimatesImpairmentSystematic searchMin decreaseRiskCreatinine
2005
The generalizability of observational data to elderly patients was dependent on the research question in a systematic review
Gross CP, Garg PP, Krumholz HM. The generalizability of observational data to elderly patients was dependent on the research question in a systematic review. Journal Of Clinical Epidemiology 2005, 58: 130-137. PMID: 15680745, DOI: 10.1016/j.jclinepi.2004.10.001.Peer-Reviewed Original ResearchConceptsCooperative Cardiovascular ProjectIntracranial hemorrhageSystematic reviewBeta-blocker useElderly patientsAngiography useCommunity patientsAtrial fibrillationRisk factorsObservational studyOutcome measuresRCT dataPresentation delayGlobal UtilizationT-PAPatientsSimilar predictorsTreatment variationStudy questionsCCP dataGUSTOHemorrhageReviewFibrillationAbsolute rate
2003
Overestimation of genetic risks owing to small sample sizes in cardiovascular studies
Morgan T, Coffey C, Krumholz H. Overestimation of genetic risks owing to small sample sizes in cardiovascular studies. Clinical Genetics 2003, 64: 7-17. PMID: 12791034, DOI: 10.1034/j.1399-0004.2003.00088.x.Peer-Reviewed Original ResearchConceptsACE DMyocardial infarctionRisk factorsPublication biasEnzyme deletion polymorphismStudies of angiotensinThrombotic risk factorsGenetic risk factorsPotential publication biasCardiovascular outcomesPlA2 polymorphismOdds ratioEgger's testFunnel plotSystematic reviewCardiovascular studiesRelevant outcomesOverall riskSmall sample sizeGenetic riskSample sizeDeletion polymorphismUnderpowered studiesInfarctionPLA2Efficacy and Safety of Low-Carbohydrate Diets: A Systematic Review
Bravata DM, Sanders L, Huang J, Krumholz HM, Olkin I, Gardner CD, Bravata DM. Efficacy and Safety of Low-Carbohydrate Diets: A Systematic Review. JAMA 2003, 289: 1837-1850. PMID: 12684364, DOI: 10.1001/jama.289.14.1837.Peer-Reviewed Original ResearchConceptsLow-carbohydrate dietSerum insulin levelsDiet durationSerum lipidsBlood pressureInsulin levelsSerum glucoseWeight lossAge 50 yearsParticipant weight lossLonger diet durationEnglish-language studiesSignificant adverse effectsObese patientsDietary interventionMean ageOutpatient settingCaloric intakeInclusion criteriaTotal caloriesAbstraction formCalorie intakeInsufficient evidenceSystematic reviewOutpatient recipients