2024
Internal tremors and vibrations in long COVID: a cross-sectional study
Zhou T, Sawano M, Arun A, Caraballo C, Michelsen T, McAlpine L, Bhattacharjee B, Lu Y, Khera R, Huang C, Warner F, Herrin J, Iwasaki A, Krumholz H. Internal tremors and vibrations in long COVID: a cross-sectional study. The American Journal Of Medicine 2024 PMID: 39069199, DOI: 10.1016/j.amjmed.2024.07.008.Peer-Reviewed Original ResearchNew-onset conditionsInternal tremorLong COVID symptomsCOVID symptomsNon-Hispanic whitesCross-sectional studyQuality of lifeVisual analogue scaleWorse healthHealth statusStudy participantsDemographic characteristicsAnalogue scaleOutcome variablesNeurological conditionsLong COVIDMast cell disordersTreatment experienceHealthComorbiditiesSymptomsMedian agePeopleCell disordersLong COVID Characteristics and Experience: A Descriptive Study from the Yale LISTEN Research Cohort
Sawano M, Wu Y, Shah R, Zhou T, Arun A, Khosla P, Kaleem S, Vashist A, Bhattacharjee B, Ding Q, Lu Y, Caraballo C, Warner F, Huang C, Herrin J, Putrino D, Michelsen T, Fisher L, Adinig C, Iwasaki A, Krumholz H. Long COVID Characteristics and Experience: A Descriptive Study from the Yale LISTEN Research Cohort. The American Journal Of Medicine 2024 PMID: 38663793, DOI: 10.1016/j.amjmed.2024.04.015.Peer-Reviewed Original ResearchExperiences of peopleHealth statusLong COVIDLower health statusNew-onset conditionsCommunity support servicesNon-Hispanic whitesArray of healthQuality of lifeVisual analogue scaleMental healthPsychological distressPsychological statusDescriptive studyHealthcare systemMedian scoreSupport servicesResearch cohortSocial isolationDemographic characteristicsAnalogue scaleImpact of long COVIDHealthFinancial stressParticipants
2020
Newly diagnosed diabetes and outcomes after acute myocardial infarction in young adults
Ding Q, Spatz ES, Lipska KJ, Lin H, Spertus JA, Dreyer RP, Whittemore R, Funk M, Bueno H, Krumholz HM. Newly diagnosed diabetes and outcomes after acute myocardial infarction in young adults. Heart 2020, 107: 657-666. PMID: 33082173, PMCID: PMC8005796, DOI: 10.1136/heartjnl-2020-317101.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionHealth statusDischarge diagnosisPharmacological treatmentMyocardial infarctionShort-term health statusYoung AMI Patients (VIRGO) studyDisease-specific health statusYoung adultsQuality of lifeHospital complicationsHospital mortalityMedication initiationBaseline characteristicsClinical outcomesDiabetesPatientsDiagnosisPatient studiesMonthsComplicationsInfarctionSignificant differencesOutcomesMortalityChanges in Functional Status and Health-Related Quality of Life in Older Adults After Surgical, Interventional, or Medical Management of Acute Myocardial Infarction
Mori M, Djulbegovic M, Hajduk A, Holland ML, Krumholz HM, Chaudhry SI. Changes in Functional Status and Health-Related Quality of Life in Older Adults After Surgical, Interventional, or Medical Management of Acute Myocardial Infarction. Seminars In Thoracic And Cardiovascular Surgery 2020, 33: 72-81. PMID: 32439546, PMCID: PMC7983308, DOI: 10.1053/j.semtcvs.2020.05.001.Peer-Reviewed Original ResearchConceptsCoronary artery bypass graftPercutaneous coronary interventionAcute myocardial infarctionPhysical component scaleMedical managementFunctional statusOlder patientsMyocardial infarctionArtery bypass graftHealth-related qualityAge 75 yearsPatient-centered outcomesRisk of declinePredictors of declineQuality of lifeUnadjusted incidenceCoronary interventionADL declineCardiac surgeryMedical therapyBypass graftSF-12Multivariable modelHRQoLPatients
2019
Associations between community well-being and hospitalisation rates: results from a cross-sectional study within six US states
Roy B, Riley C, Herrin J, Spatz E, Hamar B, Kell KP, Rula EY, Krumholz H. Associations between community well-being and hospitalisation rates: results from a cross-sectional study within six US states. BMJ Open 2019, 9: e030017. PMID: 31780588, PMCID: PMC6886944, DOI: 10.1136/bmjopen-2019-030017.Peer-Reviewed Original ResearchConceptsHospitalisation ratesZip codesPrimary care physician densityCross-sectional study SETTINGCancer-related admissionsRespiratory-related admissionsCross-sectional studyQuality of lifeRace/ethnicityCause hospitalisationSecondary outcomesPrimary outcomeHighest quintileUnnecessary hospitalisationAdmission ratesSD increaseHospitalisationLife benefitsPhysician densityStudy settingMain independent variableBeing IndexHospital bedsAdmissionGallup-Sharecare WellAssociation of Diabetes Mellitus With Health Status Outcomes in Young Women and Men After Acute Myocardial Infarction: Results From the VIRGO Study
Ding Q, Funk M, Spatz ES, Whittemore R, Lin H, Lipska KJ, Dreyer RP, Spertus JA, Krumholz HM. Association of Diabetes Mellitus With Health Status Outcomes in Young Women and Men After Acute Myocardial Infarction: Results From the VIRGO Study. Journal Of The American Heart Association 2019, 8: e010988. PMID: 31441351, PMCID: PMC6755841, DOI: 10.1161/jaha.118.010988.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAge FactorsDiabetes MellitusFemaleHealth StatusHealth Status IndicatorsHumansMaleMental HealthMiddle AgedMyocardial InfarctionPatient Reported Outcome MeasuresPredictive Value of TestsPrevalencePrognosisQuality of LifeRecovery of FunctionRisk AssessmentRisk FactorsSex FactorsSpainTime FactorsUnited StatesYoung AdultConceptsAcute myocardial infarctionEuroQol visual analogue scaleSeattle Angina QuestionnaireDiabetes mellitusForm Health SurveyHealth status outcomesHealth statusVIRGO StudyAnalog scaleMyocardial infarctionHealth SurveyStatus outcomesYoung adultsSAQ angina frequencyCardiovascular risk factorsHealth status scoresRisk of mortalityWorse health statusPoor health statusQuality of lifeWorse anginaAngina QuestionnaireClinical characteristicsHealthcare useStatus score
2018
Association Between Financial Burden, Quality of Life, and Mental Health Among Those With Atherosclerotic Cardiovascular Disease in the United States
Annapureddy A, Valero-Elizondo J, Khera R, Grandhi GR, Spatz ES, Dreyer RP, Desai NR, Krumholz HM, Nasir K. Association Between Financial Burden, Quality of Life, and Mental Health Among Those With Atherosclerotic Cardiovascular Disease in the United States. Circulation Cardiovascular Quality And Outcomes 2018, 11: e005180. PMID: 30571331, DOI: 10.1161/circoutcomes.118.005180.Peer-Reviewed Original ResearchIdentifying county characteristics associated with resident well-being: A population based study
Roy B, Riley C, Herrin J, Spatz ES, Arora A, Kell KP, Welsh J, Rula EY, Krumholz HM. Identifying county characteristics associated with resident well-being: A population based study. PLOS ONE 2018, 13: e0196720. PMID: 29791476, PMCID: PMC5965855, DOI: 10.1371/journal.pone.0196720.Peer-Reviewed Original ResearchConceptsCounty-level factorsClinical careCross-sectional studyQuality of lifeBetter health outcomesMulti-dimensional assessmentHealth outcomesBeing IndexGallup-Sharecare WellUS residentsCareCounty characteristicsSurvey participantsResident wellUS countiesScoresCounty equivalentsAssessmentFactorsCohort
2017
The State of the Science on Integrating Palliative Care in Heart Failure
Gelfman L, Bakitas M, Warner Stevenson L, Kirkpatrick J, Goldstein N, Ahluwalia S, Allen L, Allen K, Arnold B, Bakitas M, Bekelman D, Buck H, Dionne-Odom J, Dougherty C, Dunbar S, Evangelista L, Fahlberg B, Fendler T, Gelfman L, Goldstein N, Hanson L, Hauptman P, Karlekar M, Kavalieratos D, Kirkpatrick J, Kirkwood P, Kono A, Krumholz H, Kutner J, Lala A, Lindenfeld J, Mancarella G, Matlock D, Matzo M, Maurer M, Morrison S, O'Donnell A, Pamboukian S, Pinney S, Prince S, Reigel B, Ritchie C, Rogers J, Spertus J, Steinhauser K, Stevenson L, Strömberg A, Sudore R, Swetz K, Teuteberg W, Teuteberg J, Tucker R, Tulsky J, Wiegand D. The State of the Science on Integrating Palliative Care in Heart Failure. Journal Of Palliative Medicine 2017, 20: 592-603. PMID: 29493362, PMCID: PMC5455612, DOI: 10.1089/jpm.2017.0178.Peer-Reviewed Original ResearchConceptsHeart failurePalliative careUncontrolled symptomsIntegrating Palliative CarePalliative care integrationAdvanced heart failureAdvanced HF patientsChronic progressive illnessLife-prolonging therapiesCare of patientsAdvance care planningQuality of careQuality of lifeHF diseaseHF patientsHealthcare utilizationProgressive illnessHF populationHigh morbidityInterdisciplinary careInterdisciplinary working groupCare planningLife careCurrent evidenceFamily caregivers
2016
The China Patient-Centred Evaluative Assessment of Cardiac Events (China PEACE)-Prospective Study of 3-Vessel Disease: rationale and design
Rao C, Bongiovanni T, Li X, Gao H, Zhang H, Li J, Zhao Y, Yuan X, Hua K, Hu S, Krumholz HM, Jiang L, Zheng Z. The China Patient-Centred Evaluative Assessment of Cardiac Events (China PEACE)-Prospective Study of 3-Vessel Disease: rationale and design. BMJ Open 2016, 6: e009743. PMID: 26880670, PMCID: PMC4762131, DOI: 10.1136/bmjopen-2015-009743.Peer-Reviewed Original ResearchConceptsComplex coronary artery diseaseCoronary artery diseaseArtery diseaseLarge cardiovascular centresCardiac eventsProspective studyCardiovascular CenterTreatment strategiesCoronary revascularisation proceduresSYNTAX score calculationThree-vessel diseaseElective coronary angiographyMedical record abstractionPatient-reported outcomesAppropriateness of treatmentQuality improvement initiativesQuality of lifeEligible patientsRevascularisation proceduresAdverse eventsGuideline adherenceHospital factorsProspective cohortSecondary preventionCoronary angiographyChina Patient-centered Evaluative Assessment of Cardiac Events Prospective Study of Acute Myocardial Infarction: Study Design
Li J, Dreyer RP, Li X, Du X, Downing NS, Li L, Zhang HB, Feng F, Guan WC, Xu X, Li SX, Lin ZQ, Masoudi FA, Spertus JA, Krumholz HM, Jiang LX, Group T. China Patient-centered Evaluative Assessment of Cardiac Events Prospective Study of Acute Myocardial Infarction: Study Design. Chinese Medical Journal 2016, 129: 72-80. PMID: 26712436, PMCID: PMC4797546, DOI: 10.4103/0366-6999.172596.Peer-Reviewed Original ResearchConceptsPatient-reported outcomesAcute myocardial infarctionChina PatientMedical historyMyocardial infarctionPatient experienceLong-term adverse eventsRisk factor controlConsecutive AMI patientsAMI studyPatient's medical historyQuality of lifeNational Coordinating CentreQuality improvement activitiesHospital outcomesCardiac eventsPatient demographicsAdverse eventsMedical chartsHealthcare utilizationAMI patientsMedication adherenceProspective studyHospitalization eventsRisk factors
2015
Gender differences in pre-event health status of young patients with acute myocardial infarction: A VIRGO study analysis
Dreyer RP, Smolderen KG, Strait KM, Beltrame JF, Lichtman JH, Lorenze NP, D’Onofrio G, Bueno H, Krumholz HM, Spertus JA. Gender differences in pre-event health status of young patients with acute myocardial infarction: A VIRGO study analysis. European Heart Journal Acute Cardiovascular Care 2015, 5: 43-54. PMID: 25681487, PMCID: PMC4658311, DOI: 10.1177/2048872615568967.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionPrior coronary artery diseaseCoronary artery diseaseHealth statusMyocardial infarctionYounger patientsArtery diseaseCoronary artery disease historyDisease-specific health statusAcute myocardial infarction patientsAggressive symptom controlCornerstone of careWorse physical functionBaseline health statusMedical record abstractionVisual analog scaleHealth status outcomesMyocardial infarction patientsDisease-specific measuresMean health scoresLogistic regression analysisQuality of lifeHealth status informationGender differencesSymptom controlSex Differences in Perceived Stress and Early Recovery in Young and Middle-Aged Patients With Acute Myocardial Infarction
Xu X, Bao H, Strait K, Spertus JA, Lichtman JH, D'Onofrio G, Spatz E, Bucholz EM, Geda M, Lorenze NP, Bueno H, Beltrame JF, Krumholz HM. Sex Differences in Perceived Stress and Early Recovery in Young and Middle-Aged Patients With Acute Myocardial Infarction. Circulation 2015, 131: 614-623. PMID: 25679303, PMCID: PMC4652932, DOI: 10.1161/circulationaha.114.012826.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionMiddle-aged patientsMyocardial infarctionMental health statusWorse recoveryHealth statusSex differencesBaseline stressSex-based disparitiesYears of ageMultiple health outcomesQuality of lifeGreater mental stressSex-based differencesClinical characteristicsFemale sexEarly recoveryPerceived Stress ScaleGeneral populationGreater psychological stressHealth outcomesImprovement scoresInfarctionPatientsYounger age
2014
Effect of Low Perceived Social Support on Health Outcomes in Young Patients With Acute Myocardial Infarction: Results From the Variation in Recovery: Role of Gender on Outcomes of Young AMI Patients (VIRGO) Study
Bucholz EM, Strait KM, Dreyer RP, Geda M, Spatz ES, Bueno H, Lichtman JH, D'Onofrio G, Spertus JA, Krumholz HM. Effect of Low Perceived Social Support on Health Outcomes in Young Patients With Acute Myocardial Infarction: Results From the Variation in Recovery: Role of Gender on Outcomes of Young AMI Patients (VIRGO) Study. Journal Of The American Heart Association 2014, 3: e001252. PMID: 25271209, PMCID: PMC4323798, DOI: 10.1161/jaha.114.001252.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionYoung AMI Patients (VIRGO) studyLow social supportQuality of lifeDepressive symptomsHealth statusYounger patientsMyocardial infarctionHealth outcomesENRICHD Social Support InventoryLow Perceived Social SupportSocial supportDepressive symptoms 12 monthsBaseline health statusLower functional statusWorse physical functioningWorse health statusPatient studiesSymptoms 12 monthsLower mental functioningMore depressive symptomsMultivariable adjustmentSocial Support InventoryAMI patientsFunctional status
2013
Centers for Cardiovascular Outcomes Research
Cook NL, Bonds DE, Kiefe CI, Curtis JP, Krumholz HM, Kressin NR, Peterson ED. Centers for Cardiovascular Outcomes Research. Circulation Cardiovascular Quality And Outcomes 2013, 6: 223-228. PMID: 23481526, PMCID: PMC3684990, DOI: 10.1161/circoutcomes.0b013e31828e8d5c.Peer-Reviewed Original ResearchMeSH KeywordsCardiovascular DiseasesContinuity of Patient CareCooperative BehaviorHealth Care ReformHealth Services ResearchHealthcare DisparitiesHumansInterdisciplinary CommunicationInterinstitutional RelationsMulticenter Studies as TopicNational Heart, Lung, and Blood Institute (U.S.)Organizational ObjectivesOutcome Assessment, Health CareProgram DevelopmentProgram EvaluationQuality Indicators, Health CareQuality of LifeTreatment OutcomeUnited StatesConceptsCardiovascular Outcomes ResearchOutcomes research programsBlood InstituteNational HeartCardiovascular conditionsCross-program collaborationOutcomes researchAcute coronary syndromeBetter patient outcomesQuality of lifeCoronary syndromeVenous thromboembolismClinical eventsCare transitionsPatient outcomesDisparate careEarly-stage investigatorsClinical practiceTranslational gapLungNational InstituteHealthcare deliveryOutcomesHeartCare
2012
Physical function and independence 1 year after myocardial infarction: Observations from the Translational Research Investigating Underlying disparities in recovery from acute Myocardial infarction: Patients' Health status registry
Dodson JA, Arnold SV, Reid KJ, Gill TM, Rich MW, Masoudi FA, Spertus JA, Krumholz HM, Alexander KP. Physical function and independence 1 year after myocardial infarction: Observations from the Translational Research Investigating Underlying disparities in recovery from acute Myocardial infarction: Patients' Health status registry. American Heart Journal 2012, 163: 790-796. PMID: 22607856, PMCID: PMC3359897, DOI: 10.1016/j.ahj.2012.02.024.Peer-Reviewed Original ResearchMeSH KeywordsActivities of Daily LivingAge FactorsAgedAngioplasty, Balloon, CoronaryAttitude to HealthCardiac CatheterizationCoronary AngiographyDepressionElectrocardiographyFemaleFollow-Up StudiesHealth SurveysHumansIncidenceIndependent LivingMaleMiddle AgedMultivariate AnalysisMyocardial InfarctionPhysical FitnessPoisson DistributionPredictive Value of TestsQuality of LifeRegistriesRisk AssessmentSickness Impact ProfileSurveys and QuestionnairesSurvivorsTime FactorsTranslational Research, BiomedicalConceptsAcute myocardial infarctionPhysical function declineFunction declinePhysical functionMyocardial infarctionHealth statusEuroQol-5DUninsured statusTime of AMIShort Form-12 Physical Component ScoreIndependence lossEnd-stage renal diseasePost-acute myocardial infarctionCardiac rehabilitation referralPhysical component scorePatients' health statusQuality of lifePoisson regression modelsTRIUMPH registryRehabilitation referralRenal diseaseNonwhite raceFemale sexRisk factorsUnmarried status
2011
Cognitive impairment and outcomes in older adult survivors of acute myocardial infarction: Findings from the Translational Research Investigating Underlying disparities in acute Myocardial infarction Patients' Health Status registry
Gharacholou SM, Reid KJ, Arnold SV, Spertus J, Rich MW, Pellikka PA, Singh M, Holsinger T, Krumholz HM, Peterson ED, Alexander KP. Cognitive impairment and outcomes in older adult survivors of acute myocardial infarction: Findings from the Translational Research Investigating Underlying disparities in acute Myocardial infarction Patients' Health Status registry. American Heart Journal 2011, 162: 860-869.e1. PMID: 22093202, PMCID: PMC3410733, DOI: 10.1016/j.ahj.2011.08.005.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionQuality of lifeMyocardial infarctionCognitive statusCognitive impairmentAcute Myocardial Infarction Patients' Health Status (TRIUMPH) registryCardiac catheterization ratesCardiac rehabilitation referralRates of hypertensionMost older patientsSurvival 1 yearNormal cognitive functionCognitive function assessmentOlder adult survivorsLess referralCatheterization ratesMulticenter registryOlder patientsCardiac rehabilitationCerebrovascular accidentRehabilitation referralInvasive careMean ageHospital treatmentAMI careAngina frequency after myocardial infarction and quality of life in older versus younger adults: The Prospective Registry Evaluating Myocardial Infarction: Event and Recovery study
Longmore RB, Spertus JA, Alexander KP, Gosch K, Reid KJ, Masoudi FA, Krumholz HM, Rich MW. Angina frequency after myocardial infarction and quality of life in older versus younger adults: The Prospective Registry Evaluating Myocardial Infarction: Event and Recovery study. American Heart Journal 2011, 161: 631-638. PMID: 21392621, DOI: 10.1016/j.ahj.2010.12.005.Peer-Reviewed Original ResearchConceptsSeattle Angina QuestionnaireCoronary artery diseaseYounger patientsAngina controlAngina frequencyOlder patientsArtery diseaseMyocardial infarctionChronic coronary artery diseaseSAQ angina frequency scoreYoung adultsAngina frequency scoreGreater HRQL improvementsHealth-related qualityQuality of lifeBaseline HRQLHRQL improvementResidual anginaAngina QuestionnaireProspective registryStable patientsMI survivorsRecent MISurvivors increasesHRQL
2009
Factors associated with racial differences in myocardial infarction outcomes.
Spertus JA, Jones PG, Masoudi FA, Rumsfeld JS, Krumholz HM. Factors associated with racial differences in myocardial infarction outcomes. Annals Of Internal Medicine 2009, 150: 314-24. PMID: 19258559, PMCID: PMC3387537, DOI: 10.7326/0003-4819-150-5-200903030-00007.Peer-Reviewed Original ResearchConceptsQuality of lifeMyocardial infarction outcomesSite of careBlack patientsMyocardial infarctionRacial differencesPost-myocardial infarction outcomesBaseline cardiac riskHigher unadjusted mortalityProspective cohort studySeattle Angina QuestionnaireAngina QuestionnaireCardiovascular outcomesCause mortalityRehospitalization ratesUnadjusted mortalityCohort studyHospital factorsPatient characteristicsWhite patientsCardiac dysfunctionCardiac riskPatient factorsPatient's symptomsNational Heart
2008
Systolic Function as a Predictor of Mortality and Quality of Life in Long‐term Survivors with Heart Failure
McNamara R, Austin B, Wang Y, Smith G, Vaccarine V, Krumholz H. Systolic Function as a Predictor of Mortality and Quality of Life in Long‐term Survivors with Heart Failure. Clinical Cardiology 2008, 31: 119-124. PMID: 18383045, PMCID: PMC6653267, DOI: 10.1002/clc.20118.Peer-Reviewed Original ResearchConceptsQuality of lifeEjection fractionHeart failureLong-term survivorsFunctional declineSystolic functionKansas City Cardiomyopathy Questionnaire scoreModest survival advantageReduced ejection fractionDaily living scoreDisease-related qualityPredictors of mortalityHeart failure patientsClinical summary scoreLong-term survivalHigh mortality rateKCCQ scoresRenal insufficiencyFailure patientsLiving scoreDiabetes mellitusOverall mortalityPrimary outcomeLimitation scoresQOL scores