2020
Rates and Predictors of Patient Underreporting of Hospitalizations During Follow-Up After Acute Myocardial Infarction
Caraballo C, Khera R, Jones PG, Decker C, Schulz W, Spertus JA, Krumholz HM. Rates and Predictors of Patient Underreporting of Hospitalizations During Follow-Up After Acute Myocardial Infarction. Circulation Cardiovascular Quality And Outcomes 2020, 13: e006231. PMID: 32552061, PMCID: PMC9465954, DOI: 10.1161/circoutcomes.119.006231.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionMyocardial infarctionHospitalization eventsMedical recordsLongitudinal multicenter cohort studyMulticenter cohort studyMedical record abstractionDifferent patient characteristicsHealth care eventsPatients' underreportingTRIUMPH registryAccuracy of reportingCohort studyPatient characteristicsRecord abstractionProspective studyClinical studiesClinical investigationHospitalizationPatientsCare eventsInfarctionEvent ratesParticipantsPredictorsPharmacological Agents Targeting Thromboinflammation in COVID-19: Review and Implications for Future Research
Bikdeli B, Madhavan MV, Gupta A, Jimenez D, Burton JR, Der Nigoghossian C, Chuich T, Nouri SN, Dreyfus I, Driggin E, Sethi S, Sehgal K, Chatterjee S, Ageno W, Madjid M, Guo Y, Tang LV, Hu Y, Bertoletti L, Giri J, Cushman M, Quéré I, Dimakakos EP, Gibson CM, Lippi G, Favaloro EJ, Fareed J, Tafur AJ, Francese DP, Batra J, Falanga A, Clerkin KJ, Uriel N, Kirtane A, McLintock C, Hunt BJ, Spyropoulos AC, Barnes GD, Eikelboom JW, Weinberg I, Schulman S, Carrier M, Piazza G, Beckman JA, Leon MB, Stone GW, Rosenkranz S, Goldhaber SZ, Parikh SA, Monreal M, Krumholz HM, Konstantinides SV, Weitz JI, Lip GYH, Group T. Pharmacological Agents Targeting Thromboinflammation in COVID-19: Review and Implications for Future Research. Thrombosis And Haemostasis 2020, 120: 1004-1024. PMID: 32473596, PMCID: PMC7516364, DOI: 10.1055/s-0040-1713152.Peer-Reviewed Original ResearchConceptsSevere acute respiratory syndrome coronavirus 2Acute respiratory syndrome coronavirus 2COVID-19Respiratory syndrome coronavirus 2Subgroup of patientsCOVID-19 patientsFuture prospective studiesManagement of thrombosisSyndrome coronavirus 2Coronavirus disease 2019Mechanism of actionViral illnessThrombotic eventsRandomized trialsProspective studyAntithrombotic effectCoronavirus 2Antithrombotic agentsAntithrombotic drugsAntiviral effectDisease 2019Thrombotic diseaseAntithrombotic propertiesDosing approachWorldwide pandemic
2018
Equalization of four cardiovascular risk algorithms after systematic recalibration: individual-participant meta-analysis of 86 prospective studies
Pennells L, Kaptoge S, Wood A, Sweeting M, Zhao X, White I, Burgess S, Willeit P, Bolton T, Moons KGM, van der Schouw YT, Selmer R, Khaw KT, Gudnason V, Assmann G, Amouyel P, Salomaa V, Kivimaki M, Nordestgaard BG, Blaha MJ, Kuller LH, Brenner H, Gillum RF, Meisinger C, Ford I, Knuiman MW, Rosengren A, Lawlor DA, Völzke H, Cooper C, Ibañez A, Casiglia E, Kauhanen J, Cooper JA, Rodriguez B, Sundström J, Barrett-Connor E, Dankner R, Nietert PJ, Davidson KW, Wallace RB, Blazer DG, Björkelund C, Donfrancesco C, Krumholz HM, Nissinen A, Davis BR, Coady S, Whincup PH, Jørgensen T, Ducimetiere P, Trevisan M, Engström G, Crespo CJ, Meade TW, Visser M, Kromhout D, Kiechl S, Daimon M, Price JF, de la Cámara A, Jukema J, Lamarche B, Onat A, Simons LA, Kavousi M, Ben-Shlomo Y, Gallacher J, Dekker JM, Arima H, Shara N, Tipping RW, Roussel R, Brunner EJ, Koenig W, Sakurai M, Pavlovic J, Gansevoort RT, Nagel D, Goldbourt U, Barr ELM, Palmieri L, Njølstad I, Sato S, Verschuren W, Varghese CV, Graham I, Onuma O, Greenland P, Woodward M, Ezzati M, Psaty BM, Sattar N, Jackson R, Ridker PM, Cook NR, D'Agostino RB, Thompson SG, Danesh J, Di Angelantonio E, Tipping R, Simpson L, Pressel S, Couper D, Nambi V, Matsushita K, Folsom A, Shaw J, Magliano D, Zimmet P, Knuiman M, Whincup P, Wannamethee S, Willeit J, Santer P, Egger G, Casas J, Amuzu A, Ben-Shlomo Y, Gallacher J, Tikhonoff V, Casiglia E, Sutherland S, Nietert P, Cushman M, Psaty B, Søgaard A, Håheim L, Ariansen I, Tybjærg-Hansen A, Jensen G, Schnohr P, Giampaoli S, Vanuzzo D, Panico S, Palmieri L, Balkau B, Bonnet F, Marre M, de la Cámara A, Herrera M, Friedlander Y, McCallum J, McLachlan S, Guralnik J, Phillips C, Guralnik J, Guralnik J, Guralnik J, Khaw K, Wareham N, Schöttker B, Saum K, Holleczek B, Nissinen A, Tolonen H, Giampaoli S, Donfrancesco C, Vartiainen E, Jousilahti P, Harald K, D’Agostino R, Massaro J, Pencina M, Vasan R, D’Agostino R, Massaro J, Pencina M, Vasan R, Kayama T, Kato T, Oizumi T, Jespersen J, Møller L, Bladbjerg E, Chetrit A, Rosengren A, Wilhelmsen L, Björkelund C, Lissner L, Nagel D, Dennison E, Kiyohara Y, Ninomiya T, Doi Y, Rodriguez B, Nijpels G, Stehouwer C, Sato S, Kazumasa Y, Iso H, Goldbourt U, Salomaa V, Vartiainen E, Kurl S, Tuomainen T, Salonen J, Visser M, Deeg D, Meade T, Nilsson P, Hedblad B, Melander O, De Boer I, DeFilippis A, Verschuren W, Sattar N, Watt G, Meisinger C, Koenig W, Koenig W, Meisinger C, Verschuren W, Rosengren A, Kuller L, Tverdal A, Gillum R, Cooper J, Kirkland S, Shimbo D, Shaffer J, Sato S, Kazumasa Y, Iso H, Ducimetiere P, Bakker S, van der Harst P, Hillege H, Crespo C, Amouyel P, Dallongeville J, Assmann G, Schulte H, Trompet S, Smit R, Stott D, van der Schouw Y, Després J, Cantin B, Dagenais G, Laughlin G, Wingard D, Khaw K, Trevisan M, Aspelund T, Eiriksdottir G, Gudmundsson E, Ikram A, van Rooij F, Franco O, Rueda-Ochoa O, Muka T, Glisic M, Tunstall-Pedoe H, Völzke H, Howard B, Zhang Y, Jolly S, Gallacher J, Davey-Smith G, Can G, Yüksel H, Nakagawa H, Morikawa Y, Miura K, Njølstad I, Ingelsson M, Giedraitis V, Ridker P, Gaziano J, Kivimaki M, Shipley M, Brunner E, Shipley M, Arndt V, Brenner H, Cook N, Ridker P, Ford I, Sattar N, Ibañez A, Geleijnse J. Equalization of four cardiovascular risk algorithms after systematic recalibration: individual-participant meta-analysis of 86 prospective studies. European Heart Journal 2018, 40: 621-631. PMID: 30476079, PMCID: PMC6374687, DOI: 10.1093/eurheartj/ehy653.Peer-Reviewed Original ResearchConceptsSystematic Coronary Risk EvaluationReynolds Risk ScoreFramingham risk scoreRisk algorithmStatin therapyCVD riskProspective studyRisk discriminationRisk scoreCardiovascular disease risk estimationPrimary prevention guidelinesCoronary Risk EvaluationRisk factor profileYear CVD riskCardiovascular risk algorithmsCVD risk algorithmsIndividual participant dataDisease risk estimationCohort EquationsCVD eventsCVD incidencePrevention guidelinesHigh riskFactor profileHead comparisonFactors Associated With Return to Work After Acute Myocardial Infarction in China
Jiang Z, Dreyer RP, Spertus JA, Masoudi FA, Li J, Zheng X, Li X, Wu C, Bai X, Hu S, Wang Y, Krumholz HM, Chen H. Factors Associated With Return to Work After Acute Myocardial Infarction in China. JAMA Network Open 2018, 1: e184831. PMID: 30646375, PMCID: PMC6324382, DOI: 10.1001/jamanetworkopen.2018.4831.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionIndex acute myocardial infarctionHistory of smokingMyocardial infarctionHospital complicationsBaseline characteristicsFemale sexPatient baseline characteristicsProspective cohort studyLower likelihoodAcute myocardial infarction hospitalizationsLogistic regression modelsMyocardial infarction hospitalizationsCohort studyPatient factorsChina PatientProspective studyChinese patientsMAIN OUTCOMEInfarctionPatientsMonthsHospitalizationComplicationsSmokingTime to hospital arrival among patients with acute myocardial infarction in China: a report from China PEACE prospective study
Guan W, Venkatesh AK, Bai X, Xuan S, Li J, Li X, Zhang H, Zheng X, Masoudi FA, Spertus JA, Krumholz HM, Jiang L. Time to hospital arrival among patients with acute myocardial infarction in China: a report from China PEACE prospective study. European Heart Journal - Quality Of Care And Clinical Outcomes 2018, 5: 63-71. PMID: 29878087, PMCID: PMC6307335, DOI: 10.1093/ehjqcco/qcy022.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionHospital arrivalSymptom onsetMyocardial infarctionMedical insuranceLower household incomeRural medical insuranceChest discomfortChest painIndex hospitalizationMedian timeMultivariable analysisAMI symptomsProspective studyAssociated FactorsPatients' perceptionsCare seekingAMI hospitalizationPatientsSymptomsHousehold incomeAMI studyHospitalizationInfarctionAverage timeRisk thresholds for alcohol consumption: combined analysis of individual-participant data for 599 912 current drinkers in 83 prospective studies
Wood AM, Kaptoge S, Butterworth AS, Willeit P, Warnakula S, Bolton T, Paige E, Paul DS, Sweeting M, Burgess S, Bell S, Astle W, Stevens D, Koulman A, Selmer RM, Verschuren WMM, Sato S, Njølstad I, Woodward M, Salomaa V, Nordestgaard BG, Yeap BB, Fletcher A, Melander O, Kuller LH, Balkau B, Marmot M, Koenig W, Casiglia E, Cooper C, Arndt V, Franco OH, Wennberg P, Gallacher J, de la Cámara AG, Völzke H, Dahm CC, Dale CE, Bergmann MM, Crespo CJ, van der Schouw YT, Kaaks R, Simons LA, Lagiou P, Schoufour JD, Boer JMA, Key TJ, Rodriguez B, Moreno-Iribas C, Davidson KW, Taylor JO, Sacerdote C, Wallace RB, Quiros JR, Tumino R, Blazer DG, Linneberg A, Daimon M, Panico S, Howard B, Skeie G, Strandberg T, Weiderpass E, Nietert PJ, Psaty BM, Kromhout D, Salamanca-Fernandez E, Kiechl S, Krumholz HM, Grioni S, Palli D, Huerta JM, Price J, Sundström J, Arriola L, Arima H, Travis RC, Panagiotakos DB, Karakatsani A, Trichopoulou A, Kühn T, Grobbee DE, Barrett-Connor E, van Schoor N, Boeing H, Overvad K, Kauhanen J, Wareham N, Langenberg C, Forouhi N, Wennberg M, Després JP, Cushman M, Cooper JA, Rodriguez CJ, Sakurai M, Shaw JE, Knuiman M, Voortman T, Meisinger C, Tjønneland A, Brenner H, Palmieri L, Dallongeville J, Brunner EJ, Assmann G, Trevisan M, Gillum RF, Ford I, Sattar N, Lazo M, Thompson SG, Ferrari P, Leon DA, Smith GD, Peto R, Jackson R, Banks E, Di Angelantonio E, Danesh J, Group E, Wood A, Kaptoge S, Butterworth A, Willeit P, Warnakula S, Bolton T, Paige E, Paul D, Sweeting M, Burgess S, Bell S, Astle W, Stevens D, Koulman A, Selmer R, Verschuren M, Sato S, Njølstad I, Woodward M, Veikko S, Nordestgaard B, Yeap B, Flecther A, Melander O, Kuller L, Balkau B, Marmot M, Koenig W, Casiglia E, Cooper C, Arndt V, Franco O, Wennberg P, Gallacher J, de la Cámara A, Völzke H, Dahm C, Dale C, Bergmann M, Crespo C, van der Schouw Y, Kaaks R, Simons L, Lagiou P, Schoufour J, Boer J, Key T, Rodriguez B, Moreno-Iribas C, Davidson K, Taylor J, Sacerdote C, Wallace R, Quiros J, Rimm E, Tumino R, Blazer D, Linneberg A, Daimon M, Panico S, Howard B, Skeie G, Salomaa V, Strandberg T, Weiderpass E, Nietert P, Psaty B, Kromhout D, Salamanca-Fernandez E, Kiechl S, Krumholz H, Grioni S, Palli D, Huerta J, Price J, Sundström J, Arriola L, Arima H, Travis R, Panagiotakos D, Karakatsani A, Trichopoulou A, Kühn T, Grobbee D, Barrett-Connor E, van Schoor N, Boeing H, Overvad K, Kauhanen J, Wareham N, Langenberg C, Forouhi N, Wennberg M, Després J, Cushman M, Cooper J, Rodriguez C, Sakurai M, Shaw J, Knuiman M, Voortman T, Meisinger C, Tjønneland A, Brenner H, Palmieri L, Dallongeville J, Brunner E, Assmann G, Trevisan M, Gillumn R, Ford I, Sattar N, Lazo M, Thompson S, Ferrari P, Leon D, Smith G, Peto R, Jackson R, Banks E, Di Angelantonio E, Danesh J. Risk thresholds for alcohol consumption: combined analysis of individual-participant data for 599 912 current drinkers in 83 prospective studies. The Lancet 2018, 391: 1513-1523. PMID: 29676281, PMCID: PMC5899998, DOI: 10.1016/s0140-6736(18)30134-x.Peer-Reviewed Original ResearchConceptsIndividual participant dataCardiovascular disease subtypesCause mortalityCurrent drinkersCardiovascular diseaseHazard ratioAlcohol consumptionMyocardial infarctionLower riskProspective studyHigh-income countriesDisease subtypesIncident cardiovascular disease eventsFatal aortic aneurysmsMinimum mortality riskTotal cardiovascular diseasePrevious cardiovascular diseaseCardiovascular disease eventsHistory of diabetesDose-response associationUK Medical Research CouncilAge 40 yearsAlcohol consumption amountBritish Heart FoundationWeeks of alcohol
2016
The china patient‐centered evaluative assessment of cardiac events (PEACE) prospective study of percutaneous coronary intervention: Study design
Du X, Pi Y, Dreyer RP, Li J, Li X, Downing NS, Li L, Feng F, Zhan L, Zhang H, Guan W, Xu X, Li S, Lin Z, Masoudi FA, Spertus JA, Krumholz HM, Jiang L, Group F. The china patient‐centered evaluative assessment of cardiac events (PEACE) prospective study of percutaneous coronary intervention: Study design. Catheterization And Cardiovascular Interventions 2016, 88: e212-e221. PMID: 26945565, PMCID: PMC5215582, DOI: 10.1002/ccd.26461.Peer-Reviewed Original ResearchMeSH KeywordsChinaClinical ProtocolsCoronary AngiographyHealth StatusHealthcare DisparitiesHumansMedication AdherenceMyocardial InfarctionPatient Reported Outcome MeasuresPatient-Centered CarePercutaneous Coronary InterventionPredictive Value of TestsProspective StudiesResearch DesignRisk AssessmentRisk FactorsSecondary PreventionTime FactorsTreatment OutcomeConceptsPercutaneous coronary interventionPatient-reported outcomesCardiovascular risk factor controlRisk factor controlProspective studyHealth statusMedical historyLong-term clinical outcomesLong-term patient outcomesHospital-level factorsIndependent core laboratoryNationwide prospective studyLong-term outcomesPatient's medical historyHospital outcomesCoronary interventionPatient demographicsSecondary preventionConsecutive patientsMedical chartsPCI indicationPrimary outcomeClinical outcomesClinical presentationHealthcare utilizationThe China Patient-Centred Evaluative Assessment of Cardiac Events (China PEACE)-Prospective Study of 3-Vessel Disease: rationale and design
Rao C, Bongiovanni T, Li X, Gao H, Zhang H, Li J, Zhao Y, Yuan X, Hua K, Hu S, Krumholz HM, Jiang L, Zheng Z. The China Patient-Centred Evaluative Assessment of Cardiac Events (China PEACE)-Prospective Study of 3-Vessel Disease: rationale and design. BMJ Open 2016, 6: e009743. PMID: 26880670, PMCID: PMC4762131, DOI: 10.1136/bmjopen-2015-009743.Peer-Reviewed Original ResearchConceptsComplex coronary artery diseaseCoronary artery diseaseArtery diseaseLarge cardiovascular centresCardiac eventsProspective studyCardiovascular CenterTreatment strategiesCoronary revascularisation proceduresSYNTAX score calculationThree-vessel diseaseElective coronary angiographyMedical record abstractionPatient-reported outcomesAppropriateness of treatmentQuality improvement initiativesQuality of lifeEligible patientsRevascularisation proceduresAdverse eventsGuideline adherenceHospital factorsProspective cohortSecondary preventionCoronary angiographyChina Patient-centered Evaluative Assessment of Cardiac Events Prospective Study of Acute Myocardial Infarction: Study Design
Li J, Dreyer RP, Li X, Du X, Downing NS, Li L, Zhang HB, Feng F, Guan WC, Xu X, Li SX, Lin ZQ, Masoudi FA, Spertus JA, Krumholz HM, Jiang LX, Group T. China Patient-centered Evaluative Assessment of Cardiac Events Prospective Study of Acute Myocardial Infarction: Study Design. Chinese Medical Journal 2016, 129: 72-80. PMID: 26712436, PMCID: PMC4797546, DOI: 10.4103/0366-6999.172596.Peer-Reviewed Original ResearchConceptsPatient-reported outcomesAcute myocardial infarctionChina PatientMedical historyMyocardial infarctionPatient experienceLong-term adverse eventsRisk factor controlConsecutive AMI patientsAMI studyPatient's medical historyQuality of lifeNational Coordinating CentreQuality improvement activitiesHospital outcomesCardiac eventsPatient demographicsAdverse eventsMedical chartsHealthcare utilizationAMI patientsMedication adherenceProspective studyHospitalization eventsRisk factors
2015
Insurance and Prehospital Delay in Patients ≤55 Years With Acute Myocardial Infarction
Chen SI, Wang Y, Dreyer R, Strait KM, Spatz ES, Xu X, Smolderen KG, Desai NR, Lorenze NP, Lichtman JH, Spertus JA, D'Onofrio G, Bueno H, Masoudi FA, Krumholz HM. Insurance and Prehospital Delay in Patients ≤55 Years With Acute Myocardial Infarction. The American Journal Of Cardiology 2015, 116: 1827-1832. PMID: 26541907, PMCID: PMC5323057, DOI: 10.1016/j.amjcard.2015.09.018.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionPrehospital delayInsurance statusMyocardial infarctionSpanish patientsGender differencesHealth care systemUS patientsProspective studyUS cohortUS womenPatientsUniversal insuranceCare systemWomenSignificant gender differencesInfarctionMenInsurance groupsHoursStatusAssociationLarge proportionDifferencesCohort
2014
Hospital Strategy Uptake and Reductions in Unplanned Readmission Rates for Patients with Heart Failure: A Prospective Study
Bradley EH, Sipsma H, Horwitz LI, Ndumele CD, Brewster AL, Curry LA, Krumholz HM. Hospital Strategy Uptake and Reductions in Unplanned Readmission Rates for Patients with Heart Failure: A Prospective Study. Journal Of General Internal Medicine 2014, 30: 605-611. PMID: 25523470, PMCID: PMC4395590, DOI: 10.1007/s11606-014-3105-5.Peer-Reviewed Original ResearchConceptsRisk-standardized readmission ratesUnplanned readmission rateUptake of strategiesReadmission ratesHeart failureProspective studyGreater reductionAvoidable Rehospitalizations (STAAR) initiativeSame time pointsFinal analytic sampleParticipantsThe studyMain MeasuresWeHospitalPatientsWeb-based surveyAnalytic sampleTime pointsBaselineHospital strategiesSignificant reductionOne-quarterMonthsMore strategiesNational sampleAssociation
2006
Perceived control and change in physical functioning after coronary artery bypass grafting: A prospective study
Barry LC, Kasl SV, Lichtman J, Vaccarino V, Krumholz HM. Perceived control and change in physical functioning after coronary artery bypass grafting: A prospective study. International Journal Of Behavioral Medicine 2006, 13: 229-236. PMID: 17078773, DOI: 10.1207/s15327558ijbm1303_6.Peer-Reviewed Original ResearchConceptsHealth-related controlCoronary artery bypassPhysical functioningArtery bypassHospital dischargeIndependent predictorsProspective studyCaucasian manMean ageSignificant associationOne-way analysisMeasure outcomesBypassIntervention effortsMonthsWeeksX timeSignificant interactionBeneficial impactPositive changesPatients
1999
Gender differences in symptom presentation associated with coronary heart disease
Milner K, Funk M, Richards S, Wilmes R, Vaccarino V, Krumholz H. Gender differences in symptom presentation associated with coronary heart disease. The American Journal Of Cardiology 1999, 84: 396-399. PMID: 10468075, DOI: 10.1016/s0002-9149(99)00322-7.Peer-Reviewed Original ResearchConceptsCoronary heart diseaseNon-chest pain symptomsChest painEmergency departmentPain symptomsUnadjusted analysesHeart diseaseSymptom presentationYale-New Haven HospitalSubgroup of patientsNurse data collectorsGender differencesMidback painProspective studyPainNauseaVomitingSymptomsPatientsWomenDyspneaSignificant gender differencesMenDiseaseIndigestion