2016
Slow Gait Speed and Risk of Mortality or Hospital Readmission After Myocardial Infarction in the Translational Research Investigating Underlying Disparities in Recovery from Acute Myocardial Infarction: Patients' Health Status Registry
Dodson JA, Arnold SV, Gosch KL, Gill TM, Spertus JA, Krumholz HM, Rich MW, Chaudhry SI, Forman DE, Masoudi FA, Alexander KP. Slow Gait Speed and Risk of Mortality or Hospital Readmission After Myocardial Infarction in the Translational Research Investigating Underlying Disparities in Recovery from Acute Myocardial Infarction: Patients' Health Status Registry. Journal Of The American Geriatrics Society 2016, 64: 596-601. PMID: 26926309, PMCID: PMC4803531, DOI: 10.1111/jgs.14016.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionMyocardial infarctionSlow gaitHospital readmissionGait speedOlder adultsCox proportional hazards regressionMarker of frailtySlow gait speedTranslational researchProportional hazards regressionOutcomes 1 yearRisk of mortalityAssessment 1 monthBaseline characteristicsObservational cohortClinical factorsDiabetes mellitusHeart failureHazards regressionPrognostic importancePrognostic valueHigh prevalenceInfarctionReadmission
2010
Variation in Recovery
Lichtman JH, Lorenze NP, D'Onofrio G, Spertus JA, Lindau ST, Morgan TM, Herrin J, Bueno H, Mattera JA, Ridker PM, Krumholz HM. Variation in Recovery. Circulation Cardiovascular Quality And Outcomes 2010, 3: 684-693. PMID: 21081748, PMCID: PMC3064946, DOI: 10.1161/circoutcomes.109.928713.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionYoung AMI patientsAMI patientsYoung womenHeart diseaseSex differencesExcess mortality riskIschemic heart diseaseRisk stratification modelPsychosocial risk factorsYears of ageQuality of careComparison cohortPrognostic factorsPrognostic importanceAMI populationMyocardial infarctionRisk factorsObservational studyMortality riskHigh riskAMI eventsPatientsAge accountWomenGeriatric Conditions and Subsequent Mortality in Older Patients With Heart Failure
Chaudhry SI, Wang Y, Gill TM, Krumholz HM. Geriatric Conditions and Subsequent Mortality in Older Patients With Heart Failure. Journal Of The American College Of Cardiology 2010, 55: 309-316. PMID: 20117435, PMCID: PMC2832791, DOI: 10.1016/j.jacc.2009.07.066.Peer-Reviewed Original ResearchConceptsLong-term mortalityGeriatric conditionsNet reclassification improvementMobility disabilityOlder patientsReclassification improvementRisk factorsMultivariable logistic regression modelHeart failure hospitalizationIndependent risk factorTraditional risk factorsMedical record dataFinal multivariable modelYears of ageLogistic regression modelsFailure hospitalizationTerm mortalityHeart failureIndependent predictorsPrognostic importanceMean ageMultivariable modelMedicare beneficiariesMortality rateSubsequent mortality
2007
Renal Impairment Predicts Long-Term Mortality Risk after Acute Myocardial Infarction
Smith GL, Masoudi FA, Shlipak MG, Krumholz HM, Parikh CR. Renal Impairment Predicts Long-Term Mortality Risk after Acute Myocardial Infarction. Journal Of The American Society Of Nephrology 2007, 19: 141-150. PMID: 18003773, PMCID: PMC2391037, DOI: 10.1681/asn.2007050554.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionRenal functionRenal impairmentCreatinine clearanceMortality riskMyocardial infarctionCockcroft-Gault creatinine clearanceLong-term mortality riskMild renal impairmentSevere renal impairmentNormal renal functionCohort of patientsCooperative Cardiovascular ProjectPatient ageSystolic functionHospitalized patientsPrognostic importanceRisk factorsPatientsMortalityImpairmentClearanceGFRInfarctionRiskThe Prognostic Importance of a Small Acute Decrement in Kidney Function in Hospitalized Patients: A Systematic Review and Meta-Analysis
Coca SG, Peixoto AJ, Garg AX, Krumholz HM, Parikh CR. The Prognostic Importance of a Small Acute Decrement in Kidney Function in Hospitalized Patients: A Systematic Review and Meta-Analysis. American Journal Of Kidney Diseases 2007, 50: 712-720. PMID: 17954284, DOI: 10.1053/j.ajkd.2007.07.018.Peer-Reviewed Original ResearchConceptsSerum creatinine levelsCreatinine levelsRelative riskTerm mortalityAcute changesWorse short-term outcomesClinical settingRR of deathAcute kidney injuryObservational cohort studyShort-term outcomesGreater relative riskPercentage of changeAcute decrementsKidney injuryCohort studyRenal functionHospitalized patientsKidney functionPrognostic importanceEmbase databasesWorse outcomesAcute decreaseStatistical heterogeneityAbstractTextAcute Noncardiac Conditions and In-Hospital Mortality in Patients With Acute Myocardial Infarction
Lichtman JH, Spertus JA, Reid KJ, Radford MJ, Rumsfeld JS, Allen NB, Masoudi FA, Weintraub WS, Krumholz HM. Acute Noncardiac Conditions and In-Hospital Mortality in Patients With Acute Myocardial Infarction. Circulation 2007, 116: 1925-1930. PMID: 17923572, DOI: 10.1161/circulationaha.107.722090.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionNoncardiac conditionsHospital mortalityMyocardial infarctionConcomitant conditionsCommon concomitant conditionsHours of admissionIn-Hospital MortalityMedical record reviewTime of admissionEvidence-based therapiesClinical characteristicsHospital admissionMultivariable analysisRecord reviewSevere pneumoniaPrognostic importanceUS CentersInfarctionDisease severityPatientsAdmissionMortalityStudy sampleMarked increase
2006
Time Course of Depression and Outcome of Myocardial Infarction
Parashar S, Rumsfeld JS, Spertus JA, Reid KJ, Wenger NK, Krumholz HM, Amin A, Weintraub WS, Lichtman J, Dawood N, Vaccarino V. Time Course of Depression and Outcome of Myocardial Infarction. JAMA Internal Medicine 2006, 166: 2035-2043. PMID: 17030839, DOI: 10.1001/archinte.166.18.2035.Peer-Reviewed Original ResearchMeSH KeywordsActivities of Daily LivingAngina, UnstableAntidepressive AgentsDepressionFemaleHealth StatusHumansMaleMiddle AgedMultivariate AnalysisMyocardial InfarctionOutcome Assessment, Health CarePatient ReadmissionPrognosisProspective StudiesQuality of LifeRegistriesSeverity of Illness IndexSurveys and QuestionnairesTime FactorsUnited StatesConceptsPatient Health QuestionnaireMyocardial infarctionDepressive symptomsPrognostic importanceWorse outcomesPersistent depressionHealth statusAdjusted hazard ratioAcute myocardial infarctionCorresponding odds ratiosCategories of depressionMore physical limitationsTime courseFrequent anginaHigher rehospitalizationCause rehospitalizationNondepressed patientsProspective registryHazard ratioOdds ratioHealth QuestionnaireMortality rateDisease severityRehospitalizationFirst monthAcute, Severe Noncardiac Conditions in Patients with Acute Myocardial Infarction
Lichtman JH, Fathi A, Radford MJ, Lin Z, Loeser CS, Krumholz HM. Acute, Severe Noncardiac Conditions in Patients with Acute Myocardial Infarction. The American Journal Of Medicine 2006, 119: 843-850. PMID: 17000215, DOI: 10.1016/j.amjmed.2006.03.040.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionNoncardiac conditionsHospital mortalityPrognostic importanceMyocardial infarctionMortality riskYale-New Haven HospitalExcessive mortality riskHospital mortality riskSubgroup of patientsSubset of patientsRisk-adjusted analysisRisk of deathMultivariable logistic modelCardiac severityInitial therapyConsecutive patientsClinical presentationMultivariable analysisMedical historyPatientsPatient recordsMortalityMarked increaseInfarctionIncrease in Creatinine and Cardiovascular Risk in Patients with Systolic Dysfunction after Myocardial Infarction
Jose P, Skali H, Anavekar N, Tomson C, Krumholz HM, Rouleau JL, Moye L, Pfeffer MA, Solomon SD, Investigators F. Increase in Creatinine and Cardiovascular Risk in Patients with Systolic Dysfunction after Myocardial Infarction. Journal Of The American Society Of Nephrology 2006, 17: 2886-2891. PMID: 16928807, DOI: 10.1681/asn.2006010063.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionMyocardial infarctionCaptopril groupCardiovascular riskRenal functionSerum creatininePotent independent risk factorVentricular Enlargement (SAVE) trialBaseline renal functionHeart failure populationComposite end pointIndependent risk factorSerum creatinine measurementsBaseline creatinineCardiovascular deathCardiovascular morbidityPlacebo groupRenal dysfunctionSystolic dysfunctionVentricular dysfunctionAdverse eventsPrognostic importanceFailure populationTherapeutic choiceRisk factors
2003
The association of left ventricular ejection fraction, mortality, and cause of death in stable outpatients with heart failure
Curtis JP, Sokol SI, Wang Y, Rathore SS, Ko DT, Jadbabaie F, Portnay EL, Marshalko SJ, Radford MJ, Krumholz HM. The association of left ventricular ejection fraction, mortality, and cause of death in stable outpatients with heart failure. Journal Of The American College Of Cardiology 2003, 42: 736-742. PMID: 12932612, DOI: 10.1016/s0735-1097(03)00789-7.Peer-Reviewed Original ResearchConceptsLeft ventricular ejection fractionVentricular ejection fractionHeart failureCause of deathLVEF groupHF patientsMultivariable adjustmentEjection fractionStable outpatientsAssociation of LVEFHigher left ventricular ejection fractionLow left ventricular ejection fractionDigitalis Investigation Group trialHigh LVEF groupStable HF patientsPrognostic importanceAbsolute riskPrognostic indicatorSinus rhythmGroup trialsMortality ratePatientsMortalityDeathOutpatientsLong‐Term Prognostic Importance of Total Cholesterol in Elderly Survivors of an Acute Myocardial Infarction: The Cooperative Cardiovascular Pilot Project
Foody JM, Wang Y, Kiefe CI, Ellerbeck EF, Gold J, Radford MJ, Krumholz HM. Long‐Term Prognostic Importance of Total Cholesterol in Elderly Survivors of an Acute Myocardial Infarction: The Cooperative Cardiovascular Pilot Project. Journal Of The American Geriatrics Society 2003, 51: 930-936. PMID: 12834512, DOI: 10.1046/j.1365-2389.2003.51305.x.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionTotal serum cholesterolElevated total serum cholesterolCoronary artery diseaseCause mortalityTotal cholesterolSerum cholesterolElderly survivorsPrognostic importanceMyocardial infarctionCholesterol levelsLong-term prognostic importanceRetrospective medical record reviewAdjusted hazard ratioMedical record reviewLower total cholesterolStudy inclusion criteriaYear of dischargePrimary endpointOlder patientsArtery diseaseHazard ratioRecord reviewAcute careLipid subfractionsThe prognostic importance of anemia in patients with heart failure
Kosiborod M, Smith GL, Radford MJ, Foody JM, Krumholz HM. The prognostic importance of anemia in patients with heart failure. The American Journal Of Medicine 2003, 114: 112-119. PMID: 12586230, DOI: 10.1016/s0002-9343(02)01498-5.Peer-Reviewed Original ResearchConceptsHeart failureLow hematocritHospital readmissionPrognostic importanceHematocrit levelsMultivariate Cox proportional hazards regressionLeft ventricular ejection fractionCox proportional hazards regressionTraditional risk factorsVentricular ejection fractionPrincipal discharge diagnosisProportional hazards regressionRisk of deathElderly patientsOlder patientsClinical factorsEjection fractionIndependent predictorsDischarge diagnosisHazards regressionMedian hematocritPrognostic valueMean ageTreatable conditionRisk factors
2002
The prognostic importance of different definitions of worsening renal function in congestive heart failure
Gottlieb SS, Abraham W, Butler J, Forman DE, Loh E, Massie BM, O'Connor CM, Rich MW, Stevenson LW, Young J, Krumholz HM. The prognostic importance of different definitions of worsening renal function in congestive heart failure. Journal Of Cardiac Failure 2002, 8: 136-141. PMID: 12140805, DOI: 10.1054/jcaf.2002.125289.Peer-Reviewed Original ResearchConceptsCongestive heart failureRenal functionLength of stayHeart failurePrognostic importanceDepressed ejection fractionProlonged hospital stayFinal creatinineHospital mortalityHospital stayRenal failureSerum creatinineDL increaseEjection fractionACE inhibitorsPoor prognosisPatient populationWorse outcomesPrior historyTherapeutic interventionsCreatinineStayPatientsMortalityDl
2001
Predicting one-year mortality among elderly survivors of hospitalization for an acute myocardial infarction: results from the Cooperative Cardiovascular Project
Krumholz H, Chen J, Chen Y, Wang Y, Radford M. Predicting one-year mortality among elderly survivors of hospitalization for an acute myocardial infarction: results from the Cooperative Cardiovascular Project. Journal Of The American College Of Cardiology 2001, 38: 453-459. PMID: 11499737, DOI: 10.1016/s0735-1097(01)01395-x.Peer-Reviewed Original ResearchConceptsOne-year mortalityAcute myocardial infarctionMyocardial infarctionPeripheral vascular diseaseCohort of patientsBody mass indexCooperative Cardiovascular ProjectRisk of mortalityDeath one yearPopulation-based sampleSimple risk modelRenal dysfunctionVentricular dysfunctionElderly patientsOlder patientsUrinary incontinenceHeart failureMass indexAcute carePrognostic importanceMean ageVascular diseaseMedical recordsRisk groupsOlder survivorsAn Evidence-Based Assessment of Federal Guidelines for Overweight and Obesity as They Apply to Elderly Persons
Heiat A, Vaccarino V, Krumholz HM. An Evidence-Based Assessment of Federal Guidelines for Overweight and Obesity as They Apply to Elderly Persons. JAMA Internal Medicine 2001, 161: 1194-1203. PMID: 11343442, DOI: 10.1001/archinte.161.9.1194.Peer-Reviewed Original ResearchConceptsCardiovascular mortalityElderly personsCause mortalityMortality riskCoronary heart disease eventsIdeal weightUS clinical guidelinesHeart disease eventsSignificant prognostic factorsTreatment of overweightBaseline health statusExcess mortality riskRelative mortality riskBody mass indexMiddle-aged populationHigher BMI valuesAdditional pertinent articlesEnglish-language studiesSpecific age groupsPrognostic factorsMass indexSignificant positive associationHealthy weightPrognostic importanceClinical guidelines
1998
Prognostic Importance of Emotional Support for Elderly Patients Hospitalized With Heart Failure
Krumholz H, Butler J, Miller J, Vaccarino V, Williams C, Mendes de Leon C, Seeman T, Kasl S, Berkman L. Prognostic Importance of Emotional Support for Elderly Patients Hospitalized With Heart Failure. Circulation 1998, 97: 958-964. PMID: 9529263, DOI: 10.1161/01.cir.97.10.958.Peer-Reviewed Original ResearchConceptsNonfatal cardiovascular eventsClinical heart failureHeart failureElderly patientsCardiovascular eventsPrognostic importanceNonfatal cardiovascular outcomesCoronary artery diseaseEmotional supportCommunity-based studyCardiovascular outcomesArtery diseaseIndependent predictorsUnadjusted analysesFunctional statusMedical recordsClinical severityOdds ratioEpidemiologic studiesHigh riskPatientsPsychosocial supportEstablished PopulationsAdmissionDemographic factors