2014
Risk Adjustment of Ischemic Stroke Outcomes for Comparing Hospital Performance
Katzan IL, Spertus J, Bettger JP, Bravata DM, Reeves MJ, Smith EE, Bushnell C, Higashida RT, Hinchey JA, Holloway RG, Howard G, King RB, Krumholz HM, Lutz BJ, Yeh RW. Risk Adjustment of Ischemic Stroke Outcomes for Comparing Hospital Performance. Stroke 2014, 45: 918-944. PMID: 24457296, DOI: 10.1161/01.str.0000441948.35804.77.Peer-Reviewed Original ResearchMeSH KeywordsAmerican Heart AssociationBrain IschemiaHospitalsHumansModels, OrganizationalOutcome Assessment, Health CarePatient ReadmissionPredictive Value of TestsPrognosisQuality of Health CareRecovery of FunctionReproducibility of ResultsRisk AdjustmentSample SizeStrokeTreatment OutcomeUnited StatesConceptsIschemic stroke outcomeRisk-adjustment modelsStroke severityStroke outcomeStroke careOutcome measuresHospital levelRisk-adjusted outcome comparisonsRisk adjustmentHospital-level outcomesHospital performanceVascular risk factorsImportant prognostic factorIschemic stroke careIndividual patient levelStroke severity measuresRisk-adjusted modelsHospital-level performanceQuality of strokeComparison of qualityIschemic strokePrognostic factorsComorbid conditionsFunctional outcomeMajor disability
2010
Variation in Recovery
Lichtman JH, Lorenze NP, D'Onofrio G, Spertus JA, Lindau ST, Morgan TM, Herrin J, Bueno H, Mattera JA, Ridker PM, Krumholz HM. Variation in Recovery. Circulation Cardiovascular Quality And Outcomes 2010, 3: 684-693. PMID: 21081748, PMCID: PMC3064946, DOI: 10.1161/circoutcomes.109.928713.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionYoung AMI patientsAMI patientsYoung womenHeart diseaseSex differencesExcess mortality riskIschemic heart diseaseRisk stratification modelPsychosocial risk factorsYears of ageQuality of careComparison cohortPrognostic factorsPrognostic importanceAMI populationMyocardial infarctionRisk factorsObservational studyMortality riskHigh riskAMI eventsPatientsAge accountWomen
2004
Quality of life after aortic valve replacement with tissue and mechanical implants
Sedrakyan A, Hebert P, Vaccarino V, Paltiel AD, Elefteriades JA, Mattera J, Lin Z, Roumanis SA, Krumholz HM. Quality of life after aortic valve replacement with tissue and mechanical implants. Journal Of Thoracic And Cardiovascular Surgery 2004, 128: 266-272. PMID: 15282464, DOI: 10.1016/j.jtcvs.2003.12.014.Peer-Reviewed Original ResearchConceptsAortic valve replacementQuality of lifeMechanical valve implantsMechanical valve recipientsValve replacementValve recipientsLife scoresValve implantsTissue valvesMechanical valvesMedical Outcomes Trust Short FormPopulation normsYale-New Haven HospitalMechanical valve replacementRate of complicationsUS population normsTissue valve replacementPrognostic factorsRole limitationsOnly significant differenceHealth SurveyAnalysis of covarianceBaseline qualityMean qualityPatients
2001
Depressive symptoms and risk of functional decline and death in patients with heart failure
Vaccarino V, Kasl S, Abramson J, Krumholz H. Depressive symptoms and risk of functional decline and death in patients with heart failure. Journal Of The American College Of Cardiology 2001, 38: 199-205. PMID: 11451275, DOI: 10.1016/s0735-1097(01)01334-1.Peer-Reviewed Original ResearchConceptsCoronary heart diseaseHeart failureDepressive symptomsFunctional declineCombined end pointDecompensated heart failureBaseline functional statusNegative prognostic factorGeriatric Depression ScaleYears of ageIntermediate riskHospital admissionPrognostic factorsPoor outcomePoor prognosisFunctional statusMedical historyHeart diseaseRisk factorsClinical severityDepression ScaleDaily livingHigh riskPatientsMultivariate analysisAn Evidence-Based Assessment of Federal Guidelines for Overweight and Obesity as They Apply to Elderly Persons
Heiat A, Vaccarino V, Krumholz HM. An Evidence-Based Assessment of Federal Guidelines for Overweight and Obesity as They Apply to Elderly Persons. JAMA Internal Medicine 2001, 161: 1194-1203. PMID: 11343442, DOI: 10.1001/archinte.161.9.1194.Peer-Reviewed Original ResearchConceptsCardiovascular mortalityElderly personsCause mortalityMortality riskCoronary heart disease eventsIdeal weightUS clinical guidelinesHeart disease eventsSignificant prognostic factorsTreatment of overweightBaseline health statusExcess mortality riskRelative mortality riskBody mass indexMiddle-aged populationHigher BMI valuesAdditional pertinent articlesEnglish-language studiesSpecific age groupsPrognostic factorsMass indexSignificant positive associationHealthy weightPrognostic importanceClinical guidelines
1999
Sex-Based Differences in Early Mortality after Myocardial Infarction
Vaccarino V, Parsons L, Every N, Barron H, Krumholz H. Sex-Based Differences in Early Mortality after Myocardial Infarction. New England Journal Of Medicine 1999, 341: 217-225. PMID: 10413733, DOI: 10.1056/nejm199907223410401.Peer-Reviewed Original ResearchConceptsMyocardial infarctionYears of ageMortality rateSex-based differencesYoung womenMyocardial Infarction 2Odds of deathOverall mortality rateRisk of deathShort-term mortalityHigh-risk groupLogistic regression analysisHigh mortality ratePrognostic factorsEarly mortalityEarly managementMedical historyNational registryClinical severityHigh riskOlder womenInfarctionPatientsHospitalizationWomen