2024
Decreasing alloimmunization‐specific mortality in sickle cell disease in the United States: Cost‐effectiveness of a shared transfusion resource
Ito S, Pandya A, Hauser R, Krishnamurti L, Stites E, Tormey C, Krumholz H, Hendrickson J, Goshua G. Decreasing alloimmunization‐specific mortality in sickle cell disease in the United States: Cost‐effectiveness of a shared transfusion resource. American Journal Of Hematology 2024, 99: 570-576. PMID: 38279581, DOI: 10.1002/ajh.27211.Peer-Reviewed Original ResearchSickle cell diseaseDelayed hemolytic transfusion reactionQuality-adjusted life expectancyAlloimmunized patientsPatient populationRed blood cell alloimmunizationCell diseaseCost-effective interventionMedical expenditure of patientsHealth system perspectiveExpenditure of patientsIncremental cost-effectiveness ratioHemolytic transfusion reactionsUnited StatesMarkov cohort simulationCost-effectiveAverage patient populationCost-effectiveness ratioBirth cohortAnalytical time horizonAntibody historyCohort simulationTransfusionTransfusion reactionsLife expectancy
2021
Clinical characteristics and outcomes for 7,995 patients with SARS-CoV-2 infection
McPadden J, Warner F, Young HP, Hurley NC, Pulk RA, Singh A, Durant TJS, Gong G, Desai N, Haimovich A, Taylor RA, Gunel M, Dela Cruz CS, Farhadian SF, Siner J, Villanueva M, Churchwell K, Hsiao A, Torre CJ, Velazquez EJ, Herbst RS, Iwasaki A, Ko AI, Mortazavi BJ, Krumholz HM, Schulz WL. Clinical characteristics and outcomes for 7,995 patients with SARS-CoV-2 infection. PLOS ONE 2021, 16: e0243291. PMID: 33788846, PMCID: PMC8011821, DOI: 10.1371/journal.pone.0243291.Peer-Reviewed Original ResearchConceptsSARS-CoV-2 infectionYale New Haven HealthSARS-CoV-2Hospital mortalityRisk of admissionMale sexRisk factorsSARS-CoV-2 testingInvasive mechanical ventilationSevere acute respiratory syndrome virusBurden of diseaseRT-PCR testingAcademic health systemDiverse patient populationsRespiratory syndrome virusEthnic groupsAdult patientsClinical characteristicsDischarge dispositionRespiratory supportPrimary outcomeTreatment guidelinesMechanical ventilationRetrospective studyPatient population
2018
Admission diagnoses among patients with heart failure: Variation by ACO performance on a measure of risk-standardized acute admission rates
Benchetrit L, Zimmerman C, Bao H, Dharmarajan K, Altaf F, Herrin J, Lin Z, Krumholz HM, Drye EE, Lipska KJ, Spatz ES. Admission diagnoses among patients with heart failure: Variation by ACO performance on a measure of risk-standardized acute admission rates. American Heart Journal 2018, 207: 19-26. PMID: 30404047, DOI: 10.1016/j.ahj.2018.09.006.Peer-Reviewed Original ResearchMeSH KeywordsAccountable Care OrganizationsAgedAlgorithmsAnalysis of VarianceCardiovascular DiseasesComorbidityFemaleHeart FailureHospitalizationHumansInternational Classification of DiseasesMaleMedicare Part AMedicare Part BPatient AdmissionPatient DischargePatient-Centered CareSex DistributionTime FactorsUnited StatesConceptsHeart failureAccountable care organizationsMean admission rateAdmission ratesAdmission typeAcute admission ratesNoncardiovascular conditionsAdmission diagnosisCause admission ratesMedicare Shared Savings Program Accountable Care OrganizationsRate of hospitalizationPrincipal discharge diagnosisProportion of admissionsType of admissionNoncardiovascular causesHF admissionsHF patientsPerson yearsDischarge diagnosisPatient populationPatientsAdmissionKey quality metricDiagnosisSubstantial proportion
2010
Variation in Hospital Mortality Rates for Patients With Acute Myocardial Infarction
Bradley EH, Herrin J, Curry L, Cherlin EJ, Wang Y, Webster TR, Drye EE, Normand SL, Krumholz HM. Variation in Hospital Mortality Rates for Patients With Acute Myocardial Infarction. The American Journal Of Cardiology 2010, 106: 1108-1112. PMID: 20920648, DOI: 10.1016/j.amjcard.2010.06.014.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionHospital characteristicsMyocardial infarctionMortality rateCross-sectional national studyHospital mortality rateHospital patient populationAmerican Hospital Association surveyAMI dischargeMean hospitalHospital outcomesCardiac facilitiesPatient populationAMI volumeMultivariable modelPatient profilesMedicare beneficiariesHospitalHospital bedsPatientsTeaching statusUnited States Census dataStates Census dataInfarctionStatus profile
2006
A Taxonomy for Disease Management
Krumholz HM, Currie PM, Riegel B, Phillips CO, Peterson ED, Smith R, Yancy CW, Faxon DP. A Taxonomy for Disease Management. Circulation 2006, 114: 1432-1445. PMID: 16952985, DOI: 10.1161/circulationaha.106.177322.Peer-Reviewed Original ResearchMeSH KeywordsCardiologyCase ManagementClinical ProtocolsComorbidityDelivery of Health CareDepressionDiabetes MellitusDisease ManagementHeart FailureInterdisciplinary CommunicationMedicareModels, TheoreticalOutcome and Process Assessment, Health CarePatient Care ManagementPatient Care TeamPatient Education as TopicPatient SelectionRisk FactorsSocieties, MedicalTerminology as TopicConceptsDisease management programsDisease management interventionsHeart failureDisease managementHealthcare providersTerms heart failureLevel of comorbidityMedical resource utilizationHome-based programPatient-centered measuresSystematic MEDLINE searchDuration of exposureHealthcare delivery systemSecondary outcomesClinical outcomesPatient populationPostacute careCaregiver burdenMedication managementStudy protocolChronic carePatient outcomesPatient educationWriting groupManagement interventions
2002
The prognostic importance of different definitions of worsening renal function in congestive heart failure
Gottlieb SS, Abraham W, Butler J, Forman DE, Loh E, Massie BM, O'Connor CM, Rich MW, Stevenson LW, Young J, Krumholz HM. The prognostic importance of different definitions of worsening renal function in congestive heart failure. Journal Of Cardiac Failure 2002, 8: 136-141. PMID: 12140805, DOI: 10.1054/jcaf.2002.125289.Peer-Reviewed Original ResearchConceptsCongestive heart failureRenal functionLength of stayHeart failurePrognostic importanceDepressed ejection fractionProlonged hospital stayFinal creatinineHospital mortalityHospital stayRenal failureSerum creatinineDL increaseEjection fractionACE inhibitorsPoor prognosisPatient populationWorse outcomesPrior historyTherapeutic interventionsCreatinineStayPatientsMortalityDl
1998
Trends in costs of percutaneous transluminal coronary angioplasty.
Heiat A, Mattera JA, Henry GA, Chen YT, Krumholz HM. Trends in costs of percutaneous transluminal coronary angioplasty. The American Journal Of Managed Care 1998, 4: 1667-74. PMID: 10339099.Peer-Reviewed Original ResearchConceptsPercutaneous transluminal coronary angioplastyTransluminal coronary angioplastyCoronary angioplastyClinical outcomesElective percutaneous transluminal coronary angioplastyYale-New Haven HospitalCatheterization laboratory costsMedical chart reviewGroup of patientsTotal hospital costsLength of stayHospital cost accounting systemChart reviewClinical characteristicsConsecutive patientsAngiographic featuresHospital recordsContrast volumeRetrospective studyPatient populationHospital costsLesion characteristicsStent useCatheterization laboratoryPatient profiles