2020
Sex Differences in 1‐Year Health Status Following Percutaneous Coronary Intervention in Patients Without Acute Myocardial Infarction: Results From the China PEACE Prospective Study
Zheng X, Dreyer RP, Curtis JP, Liu S, Xu X, Bai X, Li X, Zhang H, Wang S, Masoudi FA, Spertus JA, Li J, Krumholz HM, Group F. Sex Differences in 1‐Year Health Status Following Percutaneous Coronary Intervention in Patients Without Acute Myocardial Infarction: Results From the China PEACE Prospective Study. Journal Of The American Heart Association 2020, 9: e014421. PMID: 32131687, PMCID: PMC7335522, DOI: 10.1161/jaha.119.014421.Peer-Reviewed Original ResearchConceptsPercutaneous coronary interventionAcute myocardial infarctionSAQ Summary ScoreCoronary interventionHealth status outcomesMyocardial infarctionHealth statusSummary scoresSAQ qualityAngina frequencyStatus outcomesPercutaneous coronary intervention studiesSAQ angina frequency scoreAngina frequency scoreCoronary Intervention StudyMarginal clinical significanceSAQ angina frequencyCardiac risk factorsChinese tertiary hospitalBackground Sex differencesSex differencesMultivariable adjustmentDiabetes mellitusTertiary hospitalLife scores
2019
Acute Kidney Injury Among Older Patients Undergoing Coronary Angiography for Acute Myocardial Infarction: The SILVER-AMI Study
Dodson JA, Hajduk A, Curtis J, Geda M, Krumholz HM, Song X, Tsang S, Blaum C, Miller P, Parikh CR, Chaudhry SI. Acute Kidney Injury Among Older Patients Undergoing Coronary Angiography for Acute Myocardial Infarction: The SILVER-AMI Study. The American Journal Of Medicine 2019, 132: e817-e826. PMID: 31170374, PMCID: PMC6891160, DOI: 10.1016/j.amjmed.2019.05.022.Peer-Reviewed Original ResearchMeSH KeywordsActivities of Daily LivingAcute Kidney InjuryAge FactorsAgedAged, 80 and overCohort StudiesCoronary AngiographyDatabases, FactualFemaleGeriatric AssessmentHospital MortalityHospitalizationHumansKaplan-Meier EstimateLogistic ModelsMaleMyocardial InfarctionOdds RatioPrognosisProportional Hazards ModelsRisk AssessmentSeverity of Illness IndexSurvival AnalysisConceptsAcute kidney injuryAcute myocardial infarctionAge-related conditionsKidney injuryBody mass indexCoronary angiographyRisk factorsMyocardial infarctionOlder patientsMean ageAcute kidney injury risk factorsAcute Myocardial Infarction StudyAcute myocardial infarction cohortOlder adultsGlobal Outcomes criteriaMyocardial Infarction StudyInjury risk factorsParticipants' mean ageSILVER-AMI StudyMultivariable adjustmentComorbid diseasesHeart failureIndependent predictorsGeriatric conditionsMass index
2017
Heterogeneity in Early Responses in ALLHAT (Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial)
Dhruva SS, Huang C, Spatz ES, Coppi AC, Warner F, Li SX, Lin H, Xu X, Furberg CD, Davis BR, Pressel SL, Coifman RR, Krumholz HM. Heterogeneity in Early Responses in ALLHAT (Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial). Hypertension 2017, 70: 94-102. PMID: 28559399, DOI: 10.1161/hypertensionaha.117.09221.Peer-Reviewed Original ResearchConceptsAntihypertensive therapySystolic blood pressure responseAdverse cardiovascular eventsFavorable initial responseBlood pressure responseHigher hazard ratioCardiovascular eventsCardiovascular outcomesHazard ratioMultivariable adjustmentHeart failureAverage SBPRandomized trialsOdds ratioCardiovascular diseaseSBPStudy participantsRespondersMonthsPressure responseImmediate respondersALLHATEarly responseInitial responseSuperior discriminationSex Differences in Inflammatory Markers and Health Status Among Young Adults With Acute Myocardial Infarction
Lu Y, Zhou S, Dreyer RP, Spatz ES, Geda M, Lorenze NP, D'Onofrio G, Lichtman JH, Spertus JA, Ridker PM, Krumholz HM. Sex Differences in Inflammatory Markers and Health Status Among Young Adults With Acute Myocardial Infarction. Circulation Cardiovascular Quality And Outcomes 2017, 10: e003470. PMID: 28228461, PMCID: PMC5459381, DOI: 10.1161/circoutcomes.116.003470.Peer-Reviewed Original ResearchMeSH Keywords1-Alkyl-2-acetylglycerophosphocholine EsteraseAdolescentAdultAge of OnsetBiomarkersChi-Square DistributionComorbidityC-Reactive ProteinFemaleHealth Status DisparitiesHumansInflammation MediatorsLinear ModelsMaleMiddle AgedMultivariate AnalysisMyocardial InfarctionProspective StudiesRisk AssessmentRisk FactorsSex FactorsSocioeconomic FactorsUnited StatesUp-RegulationYoung AdultConceptsHigh-sensitivity C-reactive proteinAcute myocardial infarctionHigher inflammatory levelsInflammatory markersPoor health statusHealth statusYoung womenMyocardial infarctionInflammatory levelsTargeted anti-inflammatory treatmentsElevated inflammatory markersResidual cholesterol riskResidual inflammatory riskSex differencesAnti-inflammatory treatmentAnti-inflammatory therapyC-reactive proteinHigher mortality riskYoung menPhospholipase A2Years of ageCardiovascular outcomesMultivariable adjustmentPatient characteristicsSecondary prevention
2014
Effect of Low Perceived Social Support on Health Outcomes in Young Patients With Acute Myocardial Infarction: Results From the Variation in Recovery: Role of Gender on Outcomes of Young AMI Patients (VIRGO) Study
Bucholz EM, Strait KM, Dreyer RP, Geda M, Spatz ES, Bueno H, Lichtman JH, D'Onofrio G, Spertus JA, Krumholz HM. Effect of Low Perceived Social Support on Health Outcomes in Young Patients With Acute Myocardial Infarction: Results From the Variation in Recovery: Role of Gender on Outcomes of Young AMI Patients (VIRGO) Study. Journal Of The American Heart Association 2014, 3: e001252. PMID: 25271209, PMCID: PMC4323798, DOI: 10.1161/jaha.114.001252.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionYoung AMI Patients (VIRGO) studyLow social supportQuality of lifeDepressive symptomsHealth statusYounger patientsMyocardial infarctionHealth outcomesENRICHD Social Support InventoryLow Perceived Social SupportSocial supportDepressive symptoms 12 monthsBaseline health statusLower functional statusWorse physical functioningWorse health statusPatient studiesSymptoms 12 monthsLower mental functioningMore depressive symptomsMultivariable adjustmentSocial Support InventoryAMI patientsFunctional statusPlace of Residence and Outcomes of Patients With Heart Failure
Bikdeli B, Wayda B, Bao H, Ross JS, Xu X, Chaudhry SI, Spertus JA, Bernheim SM, Lindenauer PK, Krumholz HM. Place of Residence and Outcomes of Patients With Heart Failure. Circulation Cardiovascular Quality And Outcomes 2014, 7: 749-756. PMID: 25074375, PMCID: PMC5323058, DOI: 10.1161/circoutcomes.113.000911.Peer-Reviewed Original ResearchConceptsNeighborhood socioeconomic statusIndividual socioeconomic statusOutcomes of patientsHeart failureHigher SES neighborhoodsSocioeconomic statusClinical factorsHeart Failure Outcomes trialPrimary end pointPatient-level factorsUS internal medicineCause mortalityCause readmissionMultivariable adjustmentOutcome trialsMedical chartsPatient interviewsLow-SES neighborhoodsCardiology practiceMortality ratePatientsPlace of residenceInternal medicineReadmissionEnd point
2012
Body Mass Index and Mortality in Acute Myocardial Infarction Patients
Bucholz EM, Rathore SS, Reid KJ, Jones PG, Chan PS, Rich MW, Spertus JA, Krumholz HM. Body Mass Index and Mortality in Acute Myocardial Infarction Patients. The American Journal Of Medicine 2012, 125: 796-803. PMID: 22483510, PMCID: PMC3408565, DOI: 10.1016/j.amjmed.2012.01.018.Peer-Reviewed Original ResearchConceptsBody mass indexHigher body mass indexAcute myocardial infarctionMyocardial infarctionLower mortalityObesity paradoxMass indexAssociation of BMIMedian body mass indexCox proportional hazards regressionAcute myocardial infarction patientsImpact of obesityRegistry of patientsProportional hazards regressionMyocardial infarction patientsContinuous variablesDomains of patientsDiabetes subgroupsClinical characteristicsMultivariable adjustmentHeart failurePatient characteristicsBMI groupsDiabetes mellitusHazards regression
2011
Operator Experience and Carotid Stenting Outcomes in Medicare Beneficiaries
Nallamothu BK, Gurm HS, Ting HH, Goodney PP, Rogers MA, Curtis JP, Dimick JB, Bates ER, Krumholz HM, Birkmeyer JD. Operator Experience and Carotid Stenting Outcomes in Medicare Beneficiaries. JAMA 2011, 306: 1338-1343. PMID: 21954477, PMCID: PMC3208144, DOI: 10.1001/jama.2011.1357.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAgedAged, 80 and overAtherosclerosisCarotid StenosisCenters for Medicare and Medicaid Services, U.S.Clinical CompetenceFee-for-Service PlansFemaleHospital MortalityHumansInsurance CoverageMaleMedicarePhysiciansQuality of Health CareRetrospective StudiesStentsStrokeTime FactorsTreatment OutcomeUnited StatesConceptsAnnual operator volumeCarotid stentingOperator volumeMedicare beneficiariesNational coverage decisionHigh riskOperator experienceStudy periodThirty-day mortalityEmbolic protection devicesHigh-volume operatorsLow-volume operatorsService Medicare beneficiariesLow annual volumeMultivariable adjustmentOlder patientsRate of failureClinical trialsCoverage decisionsObservational studyMAIN OUTCOMEPatientsClinical practiceStentingMore proceduresEffect of Living Alone on Patient Outcomes After Hospitalization for Acute Myocardial Infarction
Bucholz EM, Rathore SS, Gosch K, Schoenfeld A, Jones PG, Buchanan DM, Spertus JA, Krumholz HM. Effect of Living Alone on Patient Outcomes After Hospitalization for Acute Myocardial Infarction. The American Journal Of Cardiology 2011, 108: 943-948. PMID: 21798499, PMCID: PMC3670597, DOI: 10.1016/j.amjcard.2011.05.023.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionSeattle Angina QuestionnaireMyocardial infarctionPatient outcomesLife 1 yearRegistry of patientsHealth status measurementPhysical health componentAngina QuestionnaireMultivariable adjustmentLife scoresTreatment characteristicsComparable riskOutcome measurementsPatientsReadmissionHealth componentHealth statusMean qualityMortalityStatus measurementsComponent scaleOutcomesInfarctionSocial support
2010
Delay From Symptom Onset to Hospital Presentation for Patients With Non–ST-Segment Elevation Myocardial Infarction
Ting HH, Chen AY, Roe MT, Chan PS, Spertus JA, Nallamothu BK, Sullivan MD, DeLong ER, Bradley EH, Krumholz HM, Peterson ED. Delay From Symptom Onset to Hospital Presentation for Patients With Non–ST-Segment Elevation Myocardial Infarction. JAMA Internal Medicine 2010, 170: 1834-1841. PMID: 21059977, DOI: 10.1001/archinternmed.2010.385.Peer-Reviewed Original ResearchConceptsST-segment elevation myocardial infarctionElevation myocardial infarctionHospital presentationSymptom onsetHospital mortalityMultivariable adjustmentMyocardial infarctionUnstable Angina Patients Suppress Adverse OutcomesCan Rapid Risk StratificationSegment elevation myocardial infarctionNational quality improvement initiativeRapid Risk StratificationQuality improvement initiativesMedian delay timeSecular trendsNon–STCurrent smokingRisk stratificationNonwhite raceAdverse outcomesFemale sexOdds ratioEarly presentationAmerican CollegePatients
2009
Association of Door-to-Balloon Time and Mortality in Patients ≥65 Years With ST-Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention
Rathore SS, Curtis JP, Nallamothu BK, Wang Y, Foody JM, Kosiborod M, Masoudi FA, Havranek EP, Krumholz HM. Association of Door-to-Balloon Time and Mortality in Patients ≥65 Years With ST-Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention. The American Journal Of Cardiology 2009, 104: 1198-1203. PMID: 19840562, PMCID: PMC2790921, DOI: 10.1016/j.amjcard.2009.06.034.Peer-Reviewed Original ResearchConceptsPrimary percutaneous coronary interventionPrimary PCIST-elevation myocardial infarctionPercutaneous coronary interventionBalloon timeMyocardial infarctionCoronary interventionAssociation of doorMinutes of admissionSecond-degree fractional polynomialsLogistic regression analysisFractional polynomial modelsMultivariable adjustmentLonger doorMedian doorCurrent guidelinesPatientsMortalityInfarctionRegression analysisFractional polynomialsAssociationInterventionMinutesTreatmentThe Association of Cognitive and Somatic Depressive Symptoms With Depression Recognition and Outcomes After Myocardial Infarction
Smolderen KG, Spertus JA, Reid KJ, Buchanan DM, Krumholz HM, Denollet J, Vaccarino V, Chan PS. The Association of Cognitive and Somatic Depressive Symptoms With Depression Recognition and Outcomes After Myocardial Infarction. Circulation Cardiovascular Quality And Outcomes 2009, 2: 328-337. PMID: 20031858, PMCID: PMC2779543, DOI: 10.1161/circoutcomes.109.868588.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionCognitive depressive symptomsSomatic depressive symptomsDepressive symptomsSomatic symptomsAMI patientsMyocardial infarctionCognitive symptomsUnadjusted Cox regression analysisPatient Health Questionnaire scoresDepression recognitionLong-term prognosisCox regression analysisLong-term outcomesRecognition of depressionAssociation of CognitiveCause mortalityCause rehospitalizationIndex hospitalizationMultivariable adjustmentAMI registrySymptom scoresClinical recognitionIndependent associationMedical recordsRelationship Between Spontaneous and Iatrogenic Hypoglycemia and Mortality in Patients Hospitalized With Acute Myocardial Infarction
Kosiborod M, Inzucchi SE, Goyal A, Krumholz HM, Masoudi FA, Xiao L, Spertus JA. Relationship Between Spontaneous and Iatrogenic Hypoglycemia and Mortality in Patients Hospitalized With Acute Myocardial Infarction. JAMA 2009, 301: 1556-1564. PMID: 19366775, DOI: 10.1001/jama.2009.496.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionInsulin therapyHospital mortalityIatrogenic hypoglycemiaHypoglycemic eventsMyocardial infarctionMortality riskGlucose-lowering therapyRetrospective cohort studySubgroup of patientsHigher mortality riskLogistic regression modelsMore comorbiditiesSubsequent hospitalizationMultivariable adjustmentCohort studyGlucose loweringGlucose controlEpisodic hypoglycemiaMAIN OUTCOMEHypoglycemiaPatientsHealth FactsHigh mortalityTherapyElevated Admission Glucose and Mortality in Elderly Patients Hospitalized With Heart Failure
Kosiborod M, Inzucchi SE, Spertus JA, Wang Y, Masoudi FA, Havranek EP, Krumholz HM. Elevated Admission Glucose and Mortality in Elderly Patients Hospitalized With Heart Failure. Circulation 2009, 119: 1899-1907. PMID: 19332465, DOI: 10.1161/circulationaha.108.821843.Peer-Reviewed Original ResearchConceptsHeart failureAdmission glucoseElderly patientsDiabetes mellitusAdverse outcomesMultivariable Cox regression modelsAdmission glucose levelsElevated admission glucoseAcute myocardial infarctionCox regression modelCause mortalityMultivariable adjustmentEntire cohortGlucose controlMyocardial infarctionCardiovascular conditionsGlucose levelsLarge cohortElevated glucoseRepresentative cohortPatientsSignificant associationMortalityCohortMellitusGlucose Normalization and Outcomes in Patients With Acute Myocardial Infarction
Kosiborod M, Inzucchi SE, Krumholz HM, Masoudi FA, Goyal A, Xiao L, Jones PG, Fiske S, Spertus JA. Glucose Normalization and Outcomes in Patients With Acute Myocardial Infarction. JAMA Internal Medicine 2009, 169: 438-446. PMID: 19273773, DOI: 10.1001/archinternmed.2008.593.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionInsulin therapyMyocardial infarctionGlucose levelsGlucose normalizationBetter survivalElevated blood glucose levelsMultivariable logistic regression modelPropensity-matched analysisMean glucose levelBlood glucose levelsPropensity-matching methodsLow glucose levelsLogistic regression modelsHospital mortalityMultivariable adjustmentImproved survivalHyperglycemic patientsSpontaneous resolutionPatientsMortality rateUS hospitalsAdmissionInfarctionTherapy
2008
The Relationship Between Anemia, Change in Hematocrit Over Time and Change in Health Status in Patients With Heart Failure After Myocardial Infarction
Kosiborod M, Krumholz HM, Jones PG, Pitt B, Spertus JA. The Relationship Between Anemia, Change in Hematocrit Over Time and Change in Health Status in Patients With Heart Failure After Myocardial Infarction. Journal Of Cardiac Failure 2008, 14: 27-34. PMID: 18226770, DOI: 10.1016/j.cardfail.2007.09.009.Peer-Reviewed Original ResearchMeSH KeywordsAgedAnemiaCohort StudiesFemaleHealth Status IndicatorsHeart FailureHeart Function TestsHematocritHumansLinear ModelsMaleMiddle AgedMultivariate AnalysisMyocardial InfarctionProbabilityPrognosisQuality of LifeRisk AssessmentSickness Impact ProfileSurveys and QuestionnairesSurvival AnalysisTime FactorsConceptsKansas City Cardiomyopathy QuestionnaireHeart failureHealth status gainsHealth statusBaseline hematocritInitial hematocritMyocardial infarctionPatient’s initial hematocritPotential therapeutic targetHealth status assessmentMultivariable adjustmentAnemic patientsSevere anemiaSerial hematocritsHematocrit levelsPatientsTherapeutic targetHematocrit changesHematocritAnemiaInfarctionLinear regression modelsMonthsRegression modelsSignificant changes
2007
Identifying Heart Failure Patients at High Risk for Near-Term Cardiovascular Events With Serial Health Status Assessments
Kosiborod M, Soto GE, Jones PG, Krumholz HM, Weintraub WS, Deedwania P, Spertus JA. Identifying Heart Failure Patients at High Risk for Near-Term Cardiovascular Events With Serial Health Status Assessments. Circulation 2007, 115: 1975-1981. PMID: 17420346, DOI: 10.1161/circulationaha.106.670901.Peer-Reviewed Original ResearchConceptsKansas City Cardiomyopathy QuestionnaireHeart failure outpatientsHealth status assessmentCause mortalityCardiovascular mortalityKaplan-Meier survival analysisHigh-risk patientsHeart failure patientsAcute myocardial infarctionProportional hazards modelIntensity of treatmentStatus assessmentKCCQ scoresCardiovascular deathCardiovascular eventsClinical deteriorationMultivariable adjustmentFailure patientsHeart failureOutpatient visitsMyocardial infarctionHigh riskHospitalizationPatientsCombined outcome
2006
Socioeconomic status, treatment, and outcomes among elderly patients hospitalized with heart failure: Findings from the National Heart Failure Project
Rathore SS, Masoudi FA, Wang Y, Curtis JP, Foody JM, Havranek EP, Krumholz HM. Socioeconomic status, treatment, and outcomes among elderly patients hospitalized with heart failure: Findings from the National Heart Failure Project. American Heart Journal 2006, 152: 371-378. PMID: 16875925, PMCID: PMC2790269, DOI: 10.1016/j.ahj.2005.12.002.Peer-Reviewed Original ResearchConceptsLeft ventricular systolic function assessmentHigh SES patientsVentricular systolic function assessmentHeart failureSES patientsSystolic function assessmentYear of dischargeQuality of careSocioeconomic statusMultivariable adjustmentFunction assessmentEnzyme inhibitorsNational Heart Failure ProjectHeart Failure ProjectPrescription of angiotensinLow SES patientsPatients' socioeconomic statusAssociation of SESYear of admissionMedical record dataHierarchical logistic regression modelsLow socioeconomic statusLogistic regression modelsPatient sElderly patients
2005
Anemia and Outcomes in Patients With Heart Failure: A Study From the National Heart Care Project
Kosiborod M, Curtis JP, Wang Y, Smith GL, Masoudi FA, Foody JM, Havranek EP, Krumholz HM. Anemia and Outcomes in Patients With Heart Failure: A Study From the National Heart Care Project. JAMA Internal Medicine 2005, 165: 2237-2244. PMID: 16246989, DOI: 10.1001/archinte.165.19.2237.Peer-Reviewed Original ResearchConceptsHeart failureLower hematocrit levelsIndependent predictorsHematocrit levelsComorbid illnessesHigh riskCare ProjectMultivariable logistic regression analysisPatients 65 yearsPrincipal discharge diagnosisAcute care hospitalsLogistic regression analysisLow hematocrit valuesCause mortalityHF patientsMultiple comorbiditiesMultivariable adjustmentOlder patientsCare hospitalClinical factorsHospital readmissionComorbid conditionsDischarge diagnosisSevere anemiaAdverse outcomesPrior Aspirin Use and Outcomes in Elderly Patients Hospitalized With Acute Myocardial Infarction
Portnay EL, Foody JM, Rathore SS, Wang Y, Masoudi FA, Curtis JP, Krumholz HM. Prior Aspirin Use and Outcomes in Elderly Patients Hospitalized With Acute Myocardial Infarction. Journal Of The American College Of Cardiology 2005, 46: 967-974. PMID: 16168277, PMCID: PMC2790536, DOI: 10.1016/j.jacc.2005.06.049.Peer-Reviewed Original ResearchConceptsPrior aspirin useCondition-specific readmissionAspirin useMyocardial infarctionCause readmissionMedicare beneficiariesSix-month mortalityAcute myocardial infarctionElderly patientsMultivariable adjustmentPrognostic significanceHigh riskReadmissionLower riskLower mortalityPatientsOne monthMortalityMonthsInfarctionOne-thirdNational sampleRiskMarkersAssociation