2021
Falls in older adults after hospitalization for acute myocardial infarction
Goldstein DW, Hajduk AM, Song X, Tsang S, Geda M, McClurken JB, Tinetti ME, Krumholz HM, Chaudhry SI. Falls in older adults after hospitalization for acute myocardial infarction. Journal Of The American Geriatrics Society 2021, 69: 3476-3485. PMID: 34383963, PMCID: PMC8882265, DOI: 10.1111/jgs.17398.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionSerious fallsOlder patientsMyocardial infarctionRisk factorsAge 75Older adultsMedical record adjudicationLonger hospital stayMonths of dischargeProspective cohort studyMedical record reviewSelf-reported fallsAdults age 75Logistic regression analysisAcademic medical centerHospital stayCohort studyClinical factorsRecord reviewFunctional mobilityNew medicationsFall riskMedical CenterImpaired mobility
2020
Protocol for project recovery after cardiac surgery: a single-center cohort study leveraging digital platform to characterise longitudinal patient-reported postoperative recovery patterns
Mori M, Brooks C, Spatz E, Mortazavi BJ, Dhruva SS, Linderman GC, Grab LA, Zhang Y, Geirsson A, Chaudhry SI, Krumholz HM. Protocol for project recovery after cardiac surgery: a single-center cohort study leveraging digital platform to characterise longitudinal patient-reported postoperative recovery patterns. BMJ Open 2020, 10: e036959. PMID: 32873671, PMCID: PMC7467526, DOI: 10.1136/bmjopen-2020-036959.Peer-Reviewed Original ResearchConceptsPatient-reported outcome measuresCohort studyHospital dischargeCardiac surgerySingle-center cohort studyCoronary artery bypass graftIntensive care unit dischargeMedical record review dataPostoperative patient recoveryPostoperative recovery patternsArtery bypass graftProspective cohort studyGroup-based trajectory modellingMedical record reviewRecovery patternsRecord review dataHealth information exchange platformInstitutional review boardAortic surgeryHospital coursePatient demographicsPeer-reviewed journalsClinical factorsHospital readmissionOperative details
2019
Patient-Reported Quality of Hospital Discharge Transitions: Results from the SILVER-AMI Study
Richards BG, Hajduk AM, Perry J, Krumholz HM, Khan AM, Chaudhry SI. Patient-Reported Quality of Hospital Discharge Transitions: Results from the SILVER-AMI Study. Journal Of General Internal Medicine 2019, 35: 808-814. PMID: 31654359, PMCID: PMC7080904, DOI: 10.1007/s11606-019-05414-8.Peer-Reviewed Original ResearchConceptsDays of dischargeEmergency department utilizationAcute myocardial infarctionPatient-reported qualityHospital discharge processOlder patientsAcute Myocardial Infarction StudyMyocardial Infarction StudyProspective cohort studyMedical record reviewEmergency room utilizationAdults age 75Key ResultsA totalHospital Consumer AssessmentSILVER-AMI StudyHospital discharge transitionsHigh-risk periodDesignMulti-centerCohort studyHospital dischargeMedian ageClinical outcomesRecord reviewAdverse outcomesResultsA total
2015
National assessment of early β-blocker therapy in patients with acute myocardial infarction in China, 2001-2011: The China Patient-centered Evaluative Assessment of Cardiac Events (PEACE)–Retrospective AMI Study
Zhang H, Masoudi FA, Li J, Wang Q, Li X, Spertus JA, Ross JS, Desai NR, Krumholz HM, Jiang L, Group C. National assessment of early β-blocker therapy in patients with acute myocardial infarction in China, 2001-2011: The China Patient-centered Evaluative Assessment of Cardiac Events (PEACE)–Retrospective AMI Study. American Heart Journal 2015, 170: 506-515.e1. PMID: 26385034, PMCID: PMC5459420, DOI: 10.1016/j.ahj.2015.05.012.Peer-Reviewed Original ResearchConceptsΒ-blocker therapyAcute myocardial infarctionΒ-blocker useCardiogenic shockRisk factorsAbsolute contraindicationMyocardial infarctionEarly β-blocker useLower systolic blood pressureHours of admissionMedical record reviewSystolic blood pressureClinical practice guidelinesLower heart rateQuality of careChest discomfortCardiac eventsBlood pressureRecord reviewChina PatientIdeal patientPractice guidelinesHeart rateHigh riskPatterns of use
2013
Risk Factors for Hospital Admission Among Older Persons With Newly Diagnosed Heart Failure Findings From the Cardiovascular Health Study
Chaudhry SI, McAvay G, Chen S, Whitson H, Newman AB, Krumholz HM, Gill TM. Risk Factors for Hospital Admission Among Older Persons With Newly Diagnosed Heart Failure Findings From the Cardiovascular Health Study. Journal Of The American College Of Cardiology 2013, 61: 635-642. PMID: 23391194, PMCID: PMC3576871, DOI: 10.1016/j.jacc.2012.11.027.Peer-Reviewed Original ResearchConceptsHeart failure diagnosisIndependent risk factorHospital admissionCardiovascular Health StudyHeart failureGeriatric conditionsRisk factorsMuscle weaknessSlow gaitOlder personsHealth StudyNew diagnosisNew York Heart Association functional class IIICommunity-living older personsDepressed ejection fractionHeart Failure FindingsFunctional class IIIChronic kidney diseaseCause hospital admissionsMedical record reviewRelevant clinical dataLong-term riskDiabetes mellitusEjection fractionKidney disease
2011
Development, validation, and results of a measure of 30‐day readmission following hospitalization for pneumonia
Lindenauer PK, Normand S, Drye EE, Lin Z, Goodrich K, Desai MM, Bratzler DW, O'Donnell WJ, Metersky ML, Krumholz HM. Development, validation, and results of a measure of 30‐day readmission following hospitalization for pneumonia. Journal Of Hospital Medicine 2011, 6: 142-150. PMID: 21387551, DOI: 10.1002/jhm.890.Peer-Reviewed Original ResearchConceptsHospital readmission ratesReadmission ratesOdds of readmissionRetrospective cohort studyMedical record reviewPrincipal discharge diagnosisDays of treatmentElderly patientsHospital dischargeCohort studyRecord reviewDischarge diagnosisUnadjusted ratesOutpatient MedicareMedical recordsAdministrative claimsMedicare beneficiariesReadmissionPneumoniaRisk-standardized hospital readmission ratesHospital
2007
Acute Noncardiac Conditions and In-Hospital Mortality in Patients With Acute Myocardial Infarction
Lichtman JH, Spertus JA, Reid KJ, Radford MJ, Rumsfeld JS, Allen NB, Masoudi FA, Weintraub WS, Krumholz HM. Acute Noncardiac Conditions and In-Hospital Mortality in Patients With Acute Myocardial Infarction. Circulation 2007, 116: 1925-1930. PMID: 17923572, DOI: 10.1161/circulationaha.107.722090.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionNoncardiac conditionsHospital mortalityMyocardial infarctionConcomitant conditionsCommon concomitant conditionsHours of admissionIn-Hospital MortalityMedical record reviewTime of admissionEvidence-based therapiesClinical characteristicsHospital admissionMultivariable analysisRecord reviewSevere pneumoniaPrognostic importanceUS CentersInfarctionDisease severityPatientsAdmissionMortalityStudy sampleMarked increase
2003
Long‐Term Prognostic Importance of Total Cholesterol in Elderly Survivors of an Acute Myocardial Infarction: The Cooperative Cardiovascular Pilot Project
Foody JM, Wang Y, Kiefe CI, Ellerbeck EF, Gold J, Radford MJ, Krumholz HM. Long‐Term Prognostic Importance of Total Cholesterol in Elderly Survivors of an Acute Myocardial Infarction: The Cooperative Cardiovascular Pilot Project. Journal Of The American Geriatrics Society 2003, 51: 930-936. PMID: 12834512, DOI: 10.1046/j.1365-2389.2003.51305.x.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionTotal serum cholesterolElevated total serum cholesterolCoronary artery diseaseCause mortalityTotal cholesterolSerum cholesterolElderly survivorsPrognostic importanceMyocardial infarctionCholesterol levelsLong-term prognostic importanceRetrospective medical record reviewAdjusted hazard ratioMedical record reviewLower total cholesterolStudy inclusion criteriaYear of dischargePrimary endpointOlder patientsArtery diseaseHazard ratioRecord reviewAcute careLipid subfractions
2002
Acute myocardial infarction in the elderly with diabetes
Chyun D, Vaccarino V, Murillo J, Young LH, Krumholz HM. Acute myocardial infarction in the elderly with diabetes. Heart & Lung 2002, 31: 327-339. PMID: 12487011, DOI: 10.1067/mhl.2002.126049.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionDiabetes mellitusMyocardial infarctionHeart failureComorbid conditionsMortality rateNon-Q-wave myocardial infarctionHistory of DMInsulin-treated diabetes mellitusRetrospective medical record reviewHigher body mass indexAcute MI settingPoor functional statusBlood pressure managementMedical record reviewSpecific comorbid conditionsSecondary preventive interventionsBody mass indexShort-term mortalityCooperative Cardiovascular ProjectEntire Medicare populationShort-term riskAggressive lipidDM statusChest painEvaluation of a Consumer-Oriented Internet Health Care Report Card: The Risk of Quality Ratings Based on Mortality Data
Krumholz HM, Rathore SS, Chen J, Wang Y, Radford MJ. Evaluation of a Consumer-Oriented Internet Health Care Report Card: The Risk of Quality Ratings Based on Mortality Data. JAMA 2002, 287: 1277-1287. PMID: 11886319, DOI: 10.1001/jama.287.10.1277.Peer-Reviewed Original ResearchConceptsProcess of careMortality rateHospital ratingEnzyme inhibitorsUS acute care hospitalsSystematic medical record reviewIndividual hospitalsStudy periodAcute myocardial infarction mortalityAcute reperfusion therapyReperfusion therapy ratesMedical record reviewService beneficiaries 65 yearsCooperative Cardiovascular ProjectBeneficiaries 65 yearsAcute care hospitalsMyocardial infarction mortalityHealth care report cardsQuality of careCare report cardsHospital performanceReperfusion therapyTherapy ratesCare hospitalRecord reviewNonsteroidal antiinflammatory drugs after acute myocardial infarction
Ko D, Wang Y, Berger AK, Radford MJ, Krumholz HM. Nonsteroidal antiinflammatory drugs after acute myocardial infarction. American Heart Journal 2002, 143: 475-481. PMID: 11868054, DOI: 10.1067/mhj.2002.121270.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionNonsteroidal antiinflammatory drugsNSAID therapyMyocardial infarctionAddition of aspirinMortality rateAspirin therapyElderly patientsAntiinflammatory drugsMedicare beneficiariesUse of NSAIDsRetrospective medical record reviewAdditional survival benefitMedical record reviewCooperative Cardiovascular ProjectElderly Medicare beneficiariesHospital dischargeOlder patientsSurvival benefitRecord reviewClinical informationInfarctionAspirinPatientsMedications
2001
Sex Differences in Cardiac Catheterization: The Role of Physician Gender
Rathore SS, Chen J, Wang Y, Radford MJ, Vaccarino V, Krumholz HM. Sex Differences in Cardiac Catheterization: The Role of Physician Gender. JAMA 2001, 286: 2849-2856. PMID: 11735761, DOI: 10.1001/jama.286.22.2849.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionCardiac catheterizationMale physiciansFemale physiciansPatient sexPhysician sexCardiac proceduresRetrospective medical record reviewSex differencesUS acute care hospitalsProcedure useCardiac procedure useDay of admissionMedical record reviewCooperative Cardiovascular ProjectAcute care hospitalsCare hospitalMultivariable analysisRecord reviewPotential confoundersMyocardial infarctionPhysician genderCatheterizationMAIN OUTCOMEClinical care
2000
Predictors of readmission among elderly survivors of admission with heart failure
Krumholz H, Chen Y, Wang Y, Vaccarino V, Radford M, Horwitz R. Predictors of readmission among elderly survivors of admission with heart failure. American Heart Journal 2000, 139: 72-77. PMID: 10618565, DOI: 10.1016/s0002-8703(00)90311-9.Peer-Reviewed Original ResearchConceptsHigh-risk patientsHeart failureRisk predictorsCause readmissionClinical factorsValidation cohortHeart failure-related readmissionsPrior heart failurePatients 65 yearsPredictors of readmissionRisk of readmissionMedical record reviewGroup of patientsPrincipal discharge diagnosisResource-intensive interventionsMedicare administrative databasesCreatinine levelsElderly patientsPrior admissionReadmission ratesDerivation cohortRecord reviewDischarge diagnosisAdministrative databasesConnecticut hospitals
1997
Quality of Care, Process, and Outcomes in Elderly Patients With Pneumonia
Meehan TP, Fine MJ, Krumholz HM, Scinto JD, Galusha DH, Mockalis JT, Weber GF, Petrillo MK, Houck PM, Fine JM. Quality of Care, Process, and Outcomes in Elderly Patients With Pneumonia. JAMA 1997, 278: 2080-2084. PMID: 9403422, DOI: 10.1001/jama.1997.03550230056037.Peer-Reviewed Original ResearchMeSH KeywordsAgedAnti-Bacterial AgentsBlood Specimen CollectionCenters for Medicare and Medicaid Services, U.S.FemaleHospital MortalityHumansLogistic ModelsMaleMedicareOutcome and Process Assessment, Health CarePneumoniaQuality Indicators, Health CareRetrospective StudiesSeverity of Illness IndexSurvival AnalysisUnited StatesConceptsBlood culture collectionProcess of careHospital arrivalElderly patientsAntibiotic administrationQuality of careBlood culturesMulticenter retrospective cohort studyOxygenation assessmentInitial antibiotic administrationRetrospective cohort studyCare performanceMedical record reviewHours of arrivalAcute care hospitalsLogistic regression analysisCohort studyCare hospitalImproved survivalRecord reviewHospital careMedicare patientsFrequent causePneumoniaPatientsQuality of Care for Elderly Patients Hospitalized With Heart Failure
Krumholz HM, Wang Y, Parent EM, Mockalis J, Petrillo M, Radford MJ. Quality of Care for Elderly Patients Hospitalized With Heart Failure. JAMA Internal Medicine 1997, 157: 2242-2247. PMID: 9343001, DOI: 10.1001/archinte.1997.00440400092011.Peer-Reviewed Original ResearchConceptsHeart failureQuality of careEnzyme inhibitorsElderly patientsClinical practiceResearch Clinical Practice GuidelinesLeft ventricular ejection fractionLeft ventricular systolic functionRetrospective medical record reviewAngiotensin-converting enzyme inhibitorSevere aortic stenosisPercentage of patientsVentricular systolic functionMedical record reviewVentricular ejection fractionClinical practice guidelinesPrincipal discharge diagnosisAcute care hospitalsActual clinical practiceHealth care policyChart reviewSystolic functionAortic stenosisAppropriate patientsCare hospital
1995
Quality of care for Medicare patients with acute myocardial infarction. A four-state pilot study from the Cooperative Cardiovascular Project.
Ellerbeck EF, Jencks SF, Radford MJ, Kresowik TF, Craig AS, Gold JA, Krumholz HM, Vogel RA. Quality of care for Medicare patients with acute myocardial infarction. A four-state pilot study from the Cooperative Cardiovascular Project. JAMA 1995, 273: 1509-14. PMID: 7739077, DOI: 10.1001/jama.273.19.1509.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionQuality of careMedicare patientsMyocardial infarctionRetrospective medical record reviewPercentage of patientsMedical record reviewClinical practice guidelinesCooperative Cardiovascular ProjectAcute care hospitalsHealth care professionalsPrimary hospitalizationInitial hospitalizationCare hospitalRecord reviewStandard treatmentAMI careCare indicatorsPrincipal diagnosisPractice guidelinesAMI therapyMAIN OUTCOMEHospitalizationCare professionalsPatientsQuality of Care for Medicare Patients With Acute Myocardial Infarction: A Four-State Pilot Study From the Cooperative Cardiovascular Project
Ellerbeck E, Jencks S, Radford M, Timothy F, Craig A, Gold J, Krumholz H, Vogel R. Quality of Care for Medicare Patients With Acute Myocardial Infarction: A Four-State Pilot Study From the Cooperative Cardiovascular Project. JAMA 1995, 273: 1509-1514. DOI: 10.1001/jama.1995.03520430045037.Peer-Reviewed Original ResearchAcute myocardial infarctionQuality of careMedicare patientsMyocardial infarctionΒ-blockersRetrospective medical record reviewPercentage of patientsMedical record reviewClinical practice guidelinesCooperative Cardiovascular ProjectAcute care hospitalsHealth care professionalsPrimary hospitalizationInitial hospitalizationCare hospitalRecord reviewStandard treatmentAMI careCare indicatorsPrincipal diagnosisPractice guidelinesAMI therapyHospitalizationCare professionalsPatients