2006
Serum Urea Nitrogen, Creatinine, and Estimators of Renal Function: Mortality in Older Patients With Cardiovascular Disease
Smith GL, Shlipak MG, Havranek EP, Foody JM, Masoudi FA, Rathore SS, Krumholz HM. Serum Urea Nitrogen, Creatinine, and Estimators of Renal Function: Mortality in Older Patients With Cardiovascular Disease. JAMA Internal Medicine 2006, 166: 1134-1142. PMID: 16717177, DOI: 10.1001/archinte.166.10.1134.Peer-Reviewed Original ResearchConceptsCreatinine levelsMyocardial infarctionHeart failureMDRD eGFRCardiovascular patientsSerum urea nitrogen levelsOlder cardiovascular patientsHeart failure patientsModification of DietGlomerular filtration rateUrea nitrogen levelsProportional hazards modelSerum urea nitrogenML/minMagnitude of riskRenal measuresPostdischarge mortalityRenal dysfunctionOlder patientsRenal functionFailure patientsOutcome prognosticationRetrospective cohortFiltration rateCardiovascular disease
2005
Race and Renal Impairment in Heart Failure
Smith GL, Shlipak MG, Havranek EP, Masoudi FA, McClellan WM, Foody JM, Rathore SS, Krumholz HM. Race and Renal Impairment in Heart Failure. Circulation 2005, 111: 1270-1277. PMID: 15769768, DOI: 10.1161/01.cir.0000158131.78881.d5.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overBiomarkersBlack or African AmericanCohort StudiesComorbidityCreatinineDiabetes MellitusFemaleGlomerular Filtration RateHeart FailureHumansHypertensionInpatientsKidney DiseasesMaleMedicareMortalityMyocardial InfarctionPrognosisRetrospective StudiesRisk FactorsTreatment OutcomeWhite PeopleConceptsRenal impairmentHF patientsWhite patientsMortality riskRacial differencesElderly HF patientsSimilar racial differencesGlomerular filtration rateHeart failure patientsStriking racial disparitiesMagnitude of riskDistinct morbidityElevated creatinineFailure patientsRenal functionHeart failureHigher creatinineRenal diseaseBlack patientsOptimal therapyPrognostic indicatorFiltration rateMedicare patientsMortality burdenRepresentative cohort
2003
Worsening renal function: What is a clinically meaningful change in creatinine during hospitalization with heart failure?
Smith GL, Vaccarino V, Kosiborod M, Lichtman JH, Cheng S, Watnick SG, Krumholz HM. Worsening renal function: What is a clinically meaningful change in creatinine during hospitalization with heart failure? Journal Of Cardiac Failure 2003, 9: 13-25. PMID: 12612868, DOI: 10.1054/jcaf.2003.3.Peer-Reviewed Original ResearchMeSH KeywordsAgedBiomarkersCohort StudiesConnecticutCreatinineFemaleFollow-Up StudiesHeart FailureHospitalizationHumansKidney DiseasesKidney Function TestsMaleMiddle AgedMultivariate AnalysisPredictive Value of TestsProspective StudiesRisk FactorsSensitivity and SpecificityStatistics as TopicStroke VolumeSurvival AnalysisConceptsCreatinine elevationRenal functionHeart failureAdverse outcomesRisk of deathNumber of patientsMagnitude of riskBaseline creatinineProspective cohortRisk factorsFunctional declineHigh riskPatientsCreatinineMortalityHospitalizationDeathDlImportant predictorRiskElevationMeaningful changeMaximum specificityOutcomesBetter definition