2019
Machine Learning Prediction of Mortality and Hospitalization in Heart Failure With Preserved Ejection Fraction
Angraal S, Mortazavi BJ, Gupta A, Khera R, Ahmad T, Desai NR, Jacoby DL, Masoudi FA, Spertus JA, Krumholz HM. Machine Learning Prediction of Mortality and Hospitalization in Heart Failure With Preserved Ejection Fraction. JACC Heart Failure 2019, 8: 12-21. PMID: 31606361, DOI: 10.1016/j.jchf.2019.06.013.Peer-Reviewed Original ResearchConceptsHF hospitalizationRisk of mortalityEjection fractionBlood urea nitrogen levelsLogistic regressionPrevious HF hospitalizationHeart failure hospitalizationReduced ejection fractionReceiver-operating characteristic curveRisk of deathBody mass indexBlood urea nitrogenUrea nitrogen levelsHealth status dataMean c-statisticKCCQ scoresTOPCAT trialFailure hospitalizationHeart failureHemoglobin levelsMass indexC-statisticHospitalizationUrea nitrogenMortality
2017
Impact of Telemonitoring on Health Status
Jayaram NM, Khariton Y, Krumholz HM, Chaudhry SI, Mattera J, Tang F, Herrin J, Hodshon B, Spertus JA. Impact of Telemonitoring on Health Status. Circulation Cardiovascular Quality And Outcomes 2017, 10: e004148. PMID: 29237746, PMCID: PMC5776725, DOI: 10.1161/circoutcomes.117.004148.Peer-Reviewed Original ResearchConceptsKansas City Cardiomyopathy QuestionnaireUsual careHealth statusHeart failureKCCQ overall summary scoreRecent heart failure hospitalizationDisease-specific health statusKCCQ overall summaryHeart failure hospitalizationWeeks of dischargeRandomized clinical trialsOverall summary scoreKCCQ scoresNoninvasive TelemonitoringFailure hospitalizationBaseline characteristicsSecondary outcomesTreatment armsClinical trialsSummary scoresPatientsSubscale scoresCareHospitalizationScores
2015
Racial Differences in Heart Failure Outcomes Evidence From the Tele-HF Trial (Telemonitoring to Improve Heart Failure Outcomes)
Qian F, Parzynski CS, Chaudhry SI, Hannan EL, Shaw BA, Spertus JA, Krumholz HM. Racial Differences in Heart Failure Outcomes Evidence From the Tele-HF Trial (Telemonitoring to Improve Heart Failure Outcomes). JACC Heart Failure 2015, 3: 531-538. PMID: 26160368, PMCID: PMC8635169, DOI: 10.1016/j.jchf.2015.03.005.Peer-Reviewed Original ResearchConceptsPatient-reported health statusKansas City Cardiomyopathy QuestionnaireHeart failureBlack patientsHealth statusHF hospitalizationRacial differencesBaseline KCCQ scoresClinical laboratory valuesPatient-reported outcomesSignificant racial differencesKCCQ scoresHF admissionsPatient demographicsWhite patientsLaboratory valuesPropensity score methodsPatientsHospitalizationOutcome evidenceMonthsLinear mixed modelsBaselineTrialsStatus
2008
Systolic Function as a Predictor of Mortality and Quality of Life in Long‐term Survivors with Heart Failure
McNamara R, Austin B, Wang Y, Smith G, Vaccarine V, Krumholz H. Systolic Function as a Predictor of Mortality and Quality of Life in Long‐term Survivors with Heart Failure. Clinical Cardiology 2008, 31: 119-124. PMID: 18383045, PMCID: PMC6653267, DOI: 10.1002/clc.20118.Peer-Reviewed Original ResearchConceptsQuality of lifeEjection fractionHeart failureLong-term survivorsFunctional declineSystolic functionKansas City Cardiomyopathy Questionnaire scoreModest survival advantageReduced ejection fractionDaily living scoreDisease-related qualityPredictors of mortalityHeart failure patientsClinical summary scoreLong-term survivalHigh mortality rateKCCQ scoresRenal insufficiencyFailure patientsLiving scoreDiabetes mellitusOverall mortalityPrimary outcomeLimitation scoresQOL scores
2007
Identifying Heart Failure Patients at High Risk for Near-Term Cardiovascular Events With Serial Health Status Assessments
Kosiborod M, Soto GE, Jones PG, Krumholz HM, Weintraub WS, Deedwania P, Spertus JA. Identifying Heart Failure Patients at High Risk for Near-Term Cardiovascular Events With Serial Health Status Assessments. Circulation 2007, 115: 1975-1981. PMID: 17420346, DOI: 10.1161/circulationaha.106.670901.Peer-Reviewed Original ResearchConceptsKansas City Cardiomyopathy QuestionnaireHeart failure outpatientsHealth status assessmentCause mortalityCardiovascular mortalityKaplan-Meier survival analysisHigh-risk patientsHeart failure patientsAcute myocardial infarctionProportional hazards modelIntensity of treatmentStatus assessmentKCCQ scoresCardiovascular deathCardiovascular eventsClinical deteriorationMultivariable adjustmentFailure patientsHeart failureOutpatient visitsMyocardial infarctionHigh riskHospitalizationPatientsCombined outcome
2006
Health Status Identifies Heart Failure Outpatients at Risk for Hospitalization or Death
Heidenreich PA, Spertus JA, Jones PG, Weintraub WS, Rumsfeld JS, Rathore SS, Peterson ED, Masoudi FA, Krumholz HM, Havranek EP, Conard MW, Williams RE, Consortium C. Health Status Identifies Heart Failure Outpatients at Risk for Hospitalization or Death. Journal Of The American College Of Cardiology 2006, 47: 752-756. PMID: 16487840, DOI: 10.1016/j.jacc.2005.11.021.Peer-Reviewed Original ResearchConceptsKansas City Cardiomyopathy QuestionnaireB-type natriuretic peptideKCCQ summary scoreHeart failureKCCQ scoresHealth status measuresClinical conditionsNew York Heart Association functional class IVSummary scoresStatus measuresFunctional class IVIschemic HF etiologyLower KCCQ scoresSequential multivariable modelsBaseline patient characteristicsHeart failure outpatientsPatient's clinical conditionProportional hazards regressionBNP levelsHF etiologyHF hospitalizationHF admissionsHF patientsPatient characteristicsWalk distance
2005
The Relationship Between B-type Natriuretic Peptide and Health Status in Patients With Heart Failure
Luther SA, McCullough PA, Havranek EP, Rumsfeld JS, Jones PG, Heidenreich PA, Peterson ED, Rathore SS, Krumholz HM, Weintraub WS, Spertus JA, Masoudi FA, Consortium F. The Relationship Between B-type Natriuretic Peptide and Health Status in Patients With Heart Failure. Journal Of Cardiac Failure 2005, 11: 414-421. PMID: 16105631, DOI: 10.1016/j.cardfail.2005.02.004.Peer-Reviewed Original ResearchConceptsKansas City Cardiomyopathy QuestionnaireBNP levelsHeart failureHealth statusBNP changesB-type natriuretic peptide levelsNew York Heart Association classificationB-type natriuretic peptideBaseline BNP levelsKCCQ summary scoreNatriuretic peptide levelsHeart failure severitySystolic heart failureHealth status instrumentsBaseline BNPKCCQ scoresNatriuretic peptideAssociation classificationPatients' perceptionsPeptide levelsPhysiologic measuresSummary scoresPatientsBNPDisease severityLow-to-Moderate Alcohol Intake and Health Status in Heart Failure Patients
Salisbury AC, House JA, Conard MW, Krumholz HM, Spertus JA. Low-to-Moderate Alcohol Intake and Health Status in Heart Failure Patients. Journal Of Cardiac Failure 2005, 11: 323-328. PMID: 15948080, DOI: 10.1016/j.cardfail.2004.11.009.Peer-Reviewed Original ResearchConceptsKansas City Cardiomyopathy QuestionnaireModerate alcohol intakeHealth statusHF hospitalizationAlcohol intakeAlcohol abstinenceBaseline Kansas City Cardiomyopathy QuestionnaireShort Form-12 scoresComplete alcohol abstinenceHeart failure guidelinesMulticenter observational studyHeart failure patientsModerate alcohol consumptionSF-12 scoresKCCQ scoresHF outpatientsHF patientsFailure patientsMultivariable analysisBaseline differencesObservational studyModerate drinkersAlcohol consumptionSimilar outcomesAlcohol use
2004
Prognostic Value of Health Status in Patients With Heart Failure After Acute Myocardial Infarction
Soto GE, Jones P, Weintraub WS, Krumholz HM, Spertus JA. Prognostic Value of Health Status in Patients With Heart Failure After Acute Myocardial Infarction. Circulation 2004, 110: 546-551. PMID: 15262843, DOI: 10.1161/01.cir.0000136991.85540.a9.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overAmericasCardiovascular DiseasesCohort StudiesComorbidityDisease-Free SurvivalEplerenoneEuropeFemaleHealth Status IndicatorsHeart FailureHospitalizationHumansMaleMiddle AgedMineralocorticoid Receptor AntagonistsMyocardial InfarctionPrognosisProspective StudiesRisk FactorsSeverity of Illness IndexSpironolactoneConceptsKansas City Cardiomyopathy QuestionnaireAcute myocardial infarctionHeart failureKCCQ-OSMyocardial infarctionHealth statusKCCQ scoresCardiovascular mortalityPrognostic valueDisease-specific health status instrumentRecent acute myocardial infarctionSubsequent cardiovascular eventsEvent-free survivalOutpatient clinical practiceFirst outpatient visitHealth status instrumentsPatients' health statusQuality of lifeCardiovascular eventsClinical characteristicsOutpatient visitsMultivariable modelInternational cohortFunctional limitationsClinical practice
2003
Depressive symptoms are the strongest predictors of short-term declines in health status in patients with heart failure
Rumsfeld JS, Havranek E, Masoudi FA, Peterson ED, Jones P, Tooley JF, Krumholz HM, Spertus JA, Consortium C. Depressive symptoms are the strongest predictors of short-term declines in health status in patients with heart failure. Journal Of The American College Of Cardiology 2003, 42: 1811-1817. PMID: 14642693, DOI: 10.1016/j.jacc.2003.07.013.Peer-Reviewed Original ResearchConceptsKansas City Cardiomyopathy QuestionnaireKCCQ summary scoreDepressive symptomsQuality of lifeHealth statusKCCQ scoresHeart failureDepressed patientsSummary scoresMulticenter prospective cohort studyStrongest predictorBaseline KCCQ scoresProspective cohort studySignificant depressive symptomsSpecific health statusTreatment of depressionShort-term worseningPredictors of changeHF careHF symptomsCohort studyPrimary outcomePotential confoundersPatient variablesMultivariable model