2023
Excess Mortality and Years of Potential Life Lost Among the Black Population in the US, 1999-2020
Caraballo C, Massey D, Ndumele C, Haywood T, Kaleem S, King T, Liu Y, Lu Y, Nunez-Smith M, Taylor H, Watson K, Herrin J, Yancy C, Faust J, Krumholz H. Excess Mortality and Years of Potential Life Lost Among the Black Population in the US, 1999-2020. JAMA 2023, 329: 1662-1670. PMID: 37191702, PMCID: PMC10189563, DOI: 10.1001/jama.2023.7022.Peer-Reviewed Original ResearchConceptsExcess mortality ratesExcess deathsMortality ratePotential lifeWhite populationExcess mortalitySerial cross-sectional studyHighest excess mortality ratesBlack populationCause-specific mortalityCross-sectional studyHigh mortality rateNon-Hispanic whitesYears of lifeUS national dataMiddle-aged adultsCause mortalityHeart diseaseDeath certificatesNon-Hispanic black populationMAIN OUTCOMEAge groupsDisease controlMortalityBlack males
2013
Trends in Aortic Valve Replacement for Elderly Patients in the United States, 1999-2011
Barreto-Filho JA, Wang Y, Dodson JA, Desai MM, Sugeng L, Geirsson A, Krumholz HM. Trends in Aortic Valve Replacement for Elderly Patients in the United States, 1999-2011. JAMA 2013, 310: 2078-2084. PMID: 24240935, PMCID: PMC4089974, DOI: 10.1001/jama.2013.282437.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAgedAged, 80 and overAortic ValveBicuspid Aortic Valve DiseaseBlack PeopleCohort StudiesCoronary Artery BypassCross-Sectional StudiesFee-for-Service PlansFemaleHeart Defects, CongenitalHeart Valve DiseasesHeart Valve ProsthesisHeart Valve Prosthesis ImplantationHumansLength of StayMaleMedicarePatient ReadmissionTreatment OutcomeUnited StatesConceptsSurgical aortic valve replacementAortic valve replacementValve replacementProcedure ratesElderly patientsCoronary artery bypass graft surgeryArtery bypass graft surgeryCross-sectional cohort studyPatients 85 yearsBypass graft surgeryHigh mortality rateCause readmissionCABG surgeryGraft surgeryOlder patientsCohort studyReadmission ratesTranscatheter optionsBlack patientsTranscatheter treatmentMechanical prosthesesThirty-dayContemporary outcomesMAIN OUTCOMEMedicare fee
2011
Translational Research Investigating Underlying Disparities in Acute Myocardial Infarction Patients' Health Status (TRIUMPH)
Arnold SV, Chan PS, Jones PG, Decker C, Buchanan DM, Krumholz HM, Ho PM, Spertus JA. Translational Research Investigating Underlying Disparities in Acute Myocardial Infarction Patients' Health Status (TRIUMPH). Circulation Cardiovascular Quality And Outcomes 2011, 4: 467-476. PMID: 21772003, PMCID: PMC3376532, DOI: 10.1161/circoutcomes.110.960468.Peer-Reviewed Original ResearchConceptsHealth status studiesMyocardial infarctionHealth statusPostdischarge careAcute Myocardial Infarction Patients' Health StatusSubset of patientsTranslational researchPost-MI outcomesRacial differencesHigh mortality ratePatients' health statusMI registryChart abstractionHospital dischargeWhite patientsBlack patientsVital statusMedical historyWorse outcomesTreatment characteristicsInpatient careBaseline interviewUS CentersBlood samplesPatients
2010
Discontinuation of Antihyperglycemic Therapy and Clinical Outcomes After Acute Myocardial Infarction in Older Patients With Diabetes
Lipska KJ, Wang Y, Kosiborod M, Masoudi FA, Havranek EP, Krumholz HM, Inzucchi SE. Discontinuation of Antihyperglycemic Therapy and Clinical Outcomes After Acute Myocardial Infarction in Older Patients With Diabetes. Circulation Cardiovascular Quality And Outcomes 2010, 3: 236-242. PMID: 20354220, DOI: 10.1161/circoutcomes.109.887620.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionAntihyperglycemic therapyAntihyperglycemic agentsOlder patientsMyocardial infarctionMortality rateMultivariable Cox proportional hazards modelsCox proportional hazards modelFrequency of discontinuationGlucose-lowering agentsGlucose-lowering therapyInclusion/exclusion criteriaProportional hazards modelYear of dischargeHigh mortality rateDiabetic regimenFirst rehospitalizationReadmission ratesSecondary outcomesHeart failurePrimary outcomeClinical outcomesMultivariable analysisRetrospective studyIndependent association
2008
Systolic Function as a Predictor of Mortality and Quality of Life in Long‐term Survivors with Heart Failure
McNamara R, Austin B, Wang Y, Smith G, Vaccarine V, Krumholz H. Systolic Function as a Predictor of Mortality and Quality of Life in Long‐term Survivors with Heart Failure. Clinical Cardiology 2008, 31: 119-124. PMID: 18383045, PMCID: PMC6653267, DOI: 10.1002/clc.20118.Peer-Reviewed Original ResearchConceptsQuality of lifeEjection fractionHeart failureLong-term survivorsFunctional declineSystolic functionKansas City Cardiomyopathy Questionnaire scoreModest survival advantageReduced ejection fractionDaily living scoreDisease-related qualityPredictors of mortalityHeart failure patientsClinical summary scoreLong-term survivalHigh mortality rateKCCQ scoresRenal insufficiencyFailure patientsLiving scoreDiabetes mellitusOverall mortalityPrimary outcomeLimitation scoresQOL scores
2007
Temporal Trends of Outcomes for Nonagenarians Undergoing Coronary Artery Bypass Grafting, 1993 to 1999
Lichtman JH, Kapoor R, Wang Y, Radford MJ, Allen NB, Krumholz HM. Temporal Trends of Outcomes for Nonagenarians Undergoing Coronary Artery Bypass Grafting, 1993 to 1999. The American Journal Of Cardiology 2007, 100: 1630-1634. PMID: 18036360, DOI: 10.1016/j.amjcard.2007.06.067.Peer-Reviewed Original ResearchConceptsCABG proceduresMortality outcomesMortality rateLong-term mortality outcomesShort-term mortality outcomesOverall crude mortality rateService Medicare patientsCoronary artery bypassLength of stayCrude mortality rateService Medicare beneficiariesSkilled nursing facilitiesHigh mortality rateProjected life expectancyNumber of proceduresArtery bypassDischarge dispositionMedicare patientsMedicare beneficiariesNursing facilitiesNonagenariansMean lengthTemporal trendsLife expectancyWomen
2003
Is there evidence of implicit exclusion criteria for elderly subjects in randomized trials? Evidence from the GUSTO-1 study
Krumholz HM, Gross CP, Peterson ED, Barron HV, Radford MJ, Parsons LS, Every NR. Is there evidence of implicit exclusion criteria for elderly subjects in randomized trials? Evidence from the GUSTO-1 study. American Heart Journal 2003, 146: 839-847. PMID: 14597933, DOI: 10.1016/s0002-8703(03)00408-3.Peer-Reviewed Original ResearchConceptsCooperative Cardiovascular ProjectRandomized trialsExclusion criteriaEligibility criteriaMortality rateClinical practiceKillip class III/IVClass III/IVOccluded Coronary Arteries (GUSTO-I) trialCoronary Arteries trialHospital mortality rateMyocardial infarction careTrial eligibility criteriaHigh mortality rateRetrospective registryBaseline characteristicsClinical characteristicsElderly patientsOlder patientsCCP patientsClinical presentationClinical eventsMyocardial infarctionHealthy cohortHospital characteristics
2001
Sex differences in 2-year mortality after hospital discharge for myocardial infarction.
Vaccarino V, Krumholz H, Yarzebski J, Gore J, Goldberg R. Sex differences in 2-year mortality after hospital discharge for myocardial infarction. Annals Of Internal Medicine 2001, 134: 173-81. PMID: 11177329, DOI: 10.7326/0003-4819-134-3-200102060-00007.Peer-Reviewed Original ResearchConceptsMyocardial infarctionHigh mortality rateHospital dischargeMortality rateMedical historyHigher long-term mortality ratesCommunity-based prospective cohort studyLong-term mortality ratesGreater riskMortality 2 yearsProspective cohort studyDemographic characteristicsAcute myocardial infarctionYears of ageLower mortality rateSex differencesHospital mortalityClinical characteristicsCohort studyOlder patientsAge womenCommunity hospitalLower riskInfarctionPatients
1999
Sex-Based Differences in Early Mortality after Myocardial Infarction
Vaccarino V, Parsons L, Every N, Barron H, Krumholz H. Sex-Based Differences in Early Mortality after Myocardial Infarction. New England Journal Of Medicine 1999, 341: 217-225. PMID: 10413733, DOI: 10.1056/nejm199907223410401.Peer-Reviewed Original ResearchConceptsMyocardial infarctionYears of ageMortality rateSex-based differencesYoung womenMyocardial Infarction 2Odds of deathOverall mortality rateRisk of deathShort-term mortalityHigh-risk groupLogistic regression analysisHigh mortality ratePrognostic factorsEarly mortalityEarly managementMedical historyNational registryClinical severityHigh riskOlder womenInfarctionPatientsHospitalizationWomen
1995
Sex differences in mortality after myocardial infarction. Is there evidence for an increased risk for women?
Vaccarino V, Krumholz H, Berkman L, Horwitz R. Sex differences in mortality after myocardial infarction. Is there evidence for an increased risk for women? Circulation 1995, 91: 1861-71. PMID: 7882498, DOI: 10.1161/01.cir.91.6.1861.Peer-Reviewed Original ResearchConceptsMyocardial infarctionMortality rateIncreased early mortalitySex differencesUnadjusted mortality ratesHigh mortality rateEnglish-language literatureEarly phaseImproved survivalPatient seriesEarly mortalityFemale sexRisk factorsOutcome eventsCrude rateMEDLINE searchInfarctionSurvival rateOlder ageMortalityWomenAgeMenNumber of studiesLower survival