2020
Principles of Large-scale Evidence Generation and Evaluation across a Network of Databases (LEGEND)
Schuemie MJ, Ryan PB, Pratt N, Chen R, You SC, Krumholz HM, Madigan D, Hripcsak G, Suchard MA. Principles of Large-scale Evidence Generation and Evaluation across a Network of Databases (LEGEND). Journal Of The American Medical Informatics Association 2020, 27: 1331-1337. PMID: 32909033, PMCID: PMC7481029, DOI: 10.1093/jamia/ocaa103.Peer-Reviewed Original ResearchConceptsNetwork of databasesLarge-scale Evidence GenerationObservational Health Data SciencesObservational health care databasesHealth Data SciencesHealth care dataElectronic health recordsData sciencePublication biasPatient-level informationGeneric overviewHealth recordsMethods addressAforementioned concernsHealth care databasesAnalytic codeNetworkNew paradigmSuch dataHackingEvidence generationDissemination of evidenceHypertension treatmentResidual confoundingAdministrative claims
2019
Health Care and Precision Medicine Research: Analysis of a Scalable Data Science Platform
McPadden J, Durant TJ, Bunch DR, Coppi A, Price N, Rodgerson K, Torre CJ, Byron W, Hsiao AL, Krumholz HM, Schulz WL. Health Care and Precision Medicine Research: Analysis of a Scalable Data Science Platform. Journal Of Medical Internet Research 2019, 21: e13043. PMID: 30964441, PMCID: PMC6477571, DOI: 10.2196/13043.Peer-Reviewed Original ResearchConceptsData science platformOpen source technologiesHealth care dataSource technologiesModern big data platformScience platformData management approachTraditional computer systemsBig data workloadsBig data platformBig data sourcesReal-time datasetBiomedical research dataHealth care applicationsData-driven researchPatient monitoringScalable analyticsApache StormData lakeData workloadsAnalytics platformData acquisition workflowContinuous patient monitoringUse casesData platform
2014
Big Data And New Knowledge In Medicine: The Thinking, Training, And Tools Needed For A Learning Health System
Krumholz HM. Big Data And New Knowledge In Medicine: The Thinking, Training, And Tools Needed For A Learning Health System. Health Affairs 2014, 33: 1163-1170. PMID: 25006142, PMCID: PMC5459394, DOI: 10.1377/hlthaff.2014.0053.Peer-Reviewed Original ResearchConceptsBig dataNext-generation analyticsHealth care dataNew data sourcesAdvanced analyticsData meaningLearning health systemInformation needsUnmet information needsMassive quantitiesData sourcesHealth policy makersComplexity of patientsAnalyticsLearning health care systemComparative effectiveness researchHealth care systemPopulation health researchKnowledge generationCare dataHealth systemPatientsCare systemEffectiveness researchHealth research