2022
Durable functional limitation in patients with coronavirus disease-2019 admitted to intensive care and the effect of intermediate-dose vs standard-dose anticoagulation on functional outcomes
INVESTIGATORS I, Sadeghipour P, Talasaz A, Barco S, Bakhshandeh H, Rashidi F, Rafiee F, Rezaeifar P, Jamalkhani S, Matin S, Baghizadeh E, Tahamtan O, Sharif-Kashani B, Beigmohammadi M, Farrokhpour M, Sezavar S, Payandemehr P, Dabbagh A, Moghadam K, Jimenez D, Monreal M, Maleki M, Siegerink B, Spatz E, Piazza G, Parikh S, Kirtane A, Van Tassell B, Lip G, Goldhaber S, Klok F, Krumholz H, Bikdeli B. Durable functional limitation in patients with coronavirus disease-2019 admitted to intensive care and the effect of intermediate-dose vs standard-dose anticoagulation on functional outcomes. European Journal Of Internal Medicine 2022, 103: 76-83. PMID: 35879217, PMCID: PMC9212871, DOI: 10.1016/j.ejim.2022.06.014.Peer-Reviewed Original ResearchConceptsStandard-dose prophylactic anticoagulationPatient Health Questionnaire-2Proportion of patientsProphylactic anticoagulationIntermediate doseFunctional limitationsDepressive symptomsFunctional outcomeCOVID-19Intensive care unit hospitalizationCritically Ill PatientsMultiple organ failureSevere functional limitationsFunctional Status ScaleCoronavirus disease 2019Open labelExercise limitationAirway diseaseICU patientsOrgan failureIntensive careStatus ScaleClinical trialsGrade 3Anticoagulation
2021
Trends in Differences in Health Status and Health Care Access and Affordability by Race and Ethnicity in the United States, 1999-2018
Mahajan S, Caraballo C, Lu Y, Valero-Elizondo J, Massey D, Annapureddy AR, Roy B, Riley C, Murugiah K, Onuma O, Nunez-Smith M, Forman HP, Nasir K, Herrin J, Krumholz HM. Trends in Differences in Health Status and Health Care Access and Affordability by Race and Ethnicity in the United States, 1999-2018. JAMA 2021, 326: 637-648. PMID: 34402830, PMCID: PMC8371573, DOI: 10.1001/jama.2021.9907.Peer-Reviewed Original ResearchConceptsHealth care accessFair health statusSelf-reported health statusCare accessHealth statusWhite individualsEthnic differencesLatino/HispanicNational Health Interview Survey dataSerial cross-sectional studySelf-reported functional limitationsBlack individualsHealth Interview Survey dataLow incomeCross-sectional studyCross-sectional survey studyInterview Survey dataSelf-reported raceSelf-report measuresMAIN OUTCOMEUS adultsFunctional limitationsPercentage of peopleSignificant decreaseAdults
2004
Age, functional capacity, and health-related quality of life in patients with heart failure
Masoudi FA, Rumsfeld JS, Havranek EP, House JA, Peterson ED, Krumholz HM, Spertus JA, Consortium F. Age, functional capacity, and health-related quality of life in patients with heart failure. Journal Of Cardiac Failure 2004, 10: 368-373. PMID: 15470645, DOI: 10.1016/j.cardfail.2004.01.009.Peer-Reviewed Original ResearchConceptsKansas City Cardiomyopathy QuestionnaireHealth-related qualityHeart failureYounger patientsFunctional statusNYHA classOlder patientsBetter HRQLFunctional limitationsWalk distanceNew York Heart Association classificationMulticenter prospective cohort studyOlder personsBaseline NYHA classWorse NYHA classProspective cohort studySignificant functional limitationsBaseline functional limitationsSignificant physical disabilityImportance of treatmentBaseline HRQLMultivariable adjustmentCohort studyAssociation classificationHRQLPrognostic Value of Health Status in Patients With Heart Failure After Acute Myocardial Infarction
Soto GE, Jones P, Weintraub WS, Krumholz HM, Spertus JA. Prognostic Value of Health Status in Patients With Heart Failure After Acute Myocardial Infarction. Circulation 2004, 110: 546-551. PMID: 15262843, DOI: 10.1161/01.cir.0000136991.85540.a9.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overAmericasCardiovascular DiseasesCohort StudiesComorbidityDisease-Free SurvivalEplerenoneEuropeFemaleHealth Status IndicatorsHeart FailureHospitalizationHumansMaleMiddle AgedMineralocorticoid Receptor AntagonistsMyocardial InfarctionPrognosisProspective StudiesRisk FactorsSeverity of Illness IndexSpironolactoneConceptsKansas City Cardiomyopathy QuestionnaireAcute myocardial infarctionHeart failureKCCQ-OSMyocardial infarctionHealth statusKCCQ scoresCardiovascular mortalityPrognostic valueDisease-specific health status instrumentRecent acute myocardial infarctionSubsequent cardiovascular eventsEvent-free survivalOutpatient clinical practiceFirst outpatient visitHealth status instrumentsPatients' health statusQuality of lifeCardiovascular eventsClinical characteristicsOutpatient visitsMultivariable modelInternational cohortFunctional limitationsClinical practice
2002
Depression and Risk of Heart Failure Among the Elderly: A Prospective Community-Based Study
Williams SA, Kasl SV, Heiat A, Abramson JL, Krumholz HM, Vaccarino V. Depression and Risk of Heart Failure Among the Elderly: A Prospective Community-Based Study. Psychosomatic Medicine 2002, 64: 6-12. PMID: 11818580, DOI: 10.1097/00006842-200201000-00002.Peer-Reviewed Original ResearchConceptsHeart failureIndependent risk factorCoronary heart diseaseImpact of depressionEffect of depressionHospital admissionComorbidity factorsCox regressionProspective CommunityElderly menFunctional statusHeart diseaseRisk factorsElderly womenBaseline differencesEpidemiological studiesFunctional limitationsGreater riskUnderlying causeDepressionIncidenceEstablished PopulationsCommunity sampleDepressed participantsWomen
2000
Care and outcomes of elderly patients with acute myocardial infarction by physician specialty: the effects of comorbidity and functional limitations
Chen J, Radford M, Wang Y, Krumholz H. Care and outcomes of elderly patients with acute myocardial infarction by physician specialty: the effects of comorbidity and functional limitations. The American Journal Of Medicine 2000, 108: 460-469. PMID: 10781778, DOI: 10.1016/s0002-9343(00)00331-4.Peer-Reviewed Original ResearchMeSH KeywordsActivities of Daily LivingAgedCardiologyComorbidityFamily PracticeFemaleGeriatric AssessmentHospital MortalityHospitalizationHumansInternal MedicineMaleMedicareMyocardial InfarctionPractice Guidelines as TopicPractice Patterns, Physicians'Quality Indicators, Health CareRetrospective StudiesSeverity of Illness IndexSurvival AnalysisTreatment OutcomeUnited StatesConceptsAcute myocardial infarctionMyocardial infarctionGeneral practitionersPhysician specialtyFunctional limitationsComorbid illnessesPatient characteristicsSurvival benefitComorbid conditionsCardiology careNational Cooperative Cardiovascular ProjectEffect of comorbidityCooperative Cardiovascular ProjectBoard-certified cardiologistsInternal medicine subspecialistsMost comorbiditiesClinical characteristicsElderly patientsClinical presentationSpecialty careHospital characteristicsExcess mortalityBaseline differencesMedicine subspecialistsGeneral internists