2023
Allotransplantation and Gene Therapy Equity for Children with Sickle Cell Disease: Distributional Cost-Effectiveness of Allotransplantation Vs Gene Therapy Vs Standard-of-Care in Pediatric Patients with Sickle Cell Disease in the United States
Goshua G, Ito S, Chetlapalli K, Potnis K, Calhoun C, Krishnamurti L, Krumholz H, Pandya A. Allotransplantation and Gene Therapy Equity for Children with Sickle Cell Disease: Distributional Cost-Effectiveness of Allotransplantation Vs Gene Therapy Vs Standard-of-Care in Pediatric Patients with Sickle Cell Disease in the United States. Blood 2023, 142: 490. DOI: 10.1182/blood-2023-191072.Peer-Reviewed Original ResearchSickle cell diseaseIncremental cost-effectiveness ratioDistributional cost-effectiveness analysisPediatric patientsCell diseaseCost-effectiveness analysisDisease severityHealth resource utilization dataPediatric Health Information SystemGene therapyJustifiable treatment optionTransplant-related mortalityVaso-occlusive crisisExpert clinical experienceMarrow Transplant ResearchSubstantial mortality riskVisual analog scaleQuality-adjusted life expectancyConcomitant riskCost-effectiveness ratioResource utilization dataCost-effectiveness frontierHost diseaseMaximum patientsOpioid therapy
2007
Acute Noncardiac Conditions and In-Hospital Mortality in Patients With Acute Myocardial Infarction
Lichtman JH, Spertus JA, Reid KJ, Radford MJ, Rumsfeld JS, Allen NB, Masoudi FA, Weintraub WS, Krumholz HM. Acute Noncardiac Conditions and In-Hospital Mortality in Patients With Acute Myocardial Infarction. Circulation 2007, 116: 1925-1930. PMID: 17923572, DOI: 10.1161/circulationaha.107.722090.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionNoncardiac conditionsHospital mortalityMyocardial infarctionConcomitant conditionsCommon concomitant conditionsHours of admissionIn-Hospital MortalityMedical record reviewTime of admissionEvidence-based therapiesClinical characteristicsHospital admissionMultivariable analysisRecord reviewSevere pneumoniaPrognostic importanceUS CentersInfarctionDisease severityPatientsAdmissionMortalityStudy sampleMarked increase
2006
Time Course of Depression and Outcome of Myocardial Infarction
Parashar S, Rumsfeld JS, Spertus JA, Reid KJ, Wenger NK, Krumholz HM, Amin A, Weintraub WS, Lichtman J, Dawood N, Vaccarino V. Time Course of Depression and Outcome of Myocardial Infarction. JAMA Internal Medicine 2006, 166: 2035-2043. PMID: 17030839, DOI: 10.1001/archinte.166.18.2035.Peer-Reviewed Original ResearchMeSH KeywordsActivities of Daily LivingAngina, UnstableAntidepressive AgentsDepressionFemaleHealth StatusHumansMaleMiddle AgedMultivariate AnalysisMyocardial InfarctionOutcome Assessment, Health CarePatient ReadmissionPrognosisProspective StudiesQuality of LifeRegistriesSeverity of Illness IndexSurveys and QuestionnairesTime FactorsUnited StatesConceptsPatient Health QuestionnaireMyocardial infarctionDepressive symptomsPrognostic importanceWorse outcomesPersistent depressionHealth statusAdjusted hazard ratioAcute myocardial infarctionCorresponding odds ratiosCategories of depressionMore physical limitationsTime courseFrequent anginaHigher rehospitalizationCause rehospitalizationNondepressed patientsProspective registryHazard ratioOdds ratioHealth QuestionnaireMortality rateDisease severityRehospitalizationFirst month
2005
The Relationship Between B-type Natriuretic Peptide and Health Status in Patients With Heart Failure
Luther SA, McCullough PA, Havranek EP, Rumsfeld JS, Jones PG, Heidenreich PA, Peterson ED, Rathore SS, Krumholz HM, Weintraub WS, Spertus JA, Masoudi FA, Consortium F. The Relationship Between B-type Natriuretic Peptide and Health Status in Patients With Heart Failure. Journal Of Cardiac Failure 2005, 11: 414-421. PMID: 16105631, DOI: 10.1016/j.cardfail.2005.02.004.Peer-Reviewed Original ResearchConceptsKansas City Cardiomyopathy QuestionnaireBNP levelsHeart failureHealth statusBNP changesB-type natriuretic peptide levelsNew York Heart Association classificationB-type natriuretic peptideBaseline BNP levelsKCCQ summary scoreNatriuretic peptide levelsHeart failure severitySystolic heart failureHealth status instrumentsBaseline BNPKCCQ scoresNatriuretic peptideAssociation classificationPatients' perceptionsPeptide levelsPhysiologic measuresSummary scoresPatientsBNPDisease severity
2003
Patterns of Secondary Prevention in Older Patients Undergoing Coronary Artery Bypass Grafting During Hospitalization for Acute Myocardial Infarction
Foody JM, Ferdinand FD, Galusha D, Rathore SS, Masoudi FA, Havranek EP, Nilasena D, Radford MJ, Krumholz HM. Patterns of Secondary Prevention in Older Patients Undergoing Coronary Artery Bypass Grafting During Hospitalization for Acute Myocardial Infarction. Circulation 2003, 108: 24ii--28. PMID: 12970203, DOI: 10.1161/01.cir.0000087654.26917.00.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionCoronary artery bypassOlder patientsArtery bypassSecondary preventionMyocardial infarctionAggressive risk factor modificationUtilization of therapyRisk factor modificationLong-term mortalityYears of ageCABG patientsDischarge aspirinDischarge therapyEligible patientsCardiovascular eventsSurgical mortalityLipid loweringACE inhibitorsFactor modificationMedical recordsCABGPatientsEnzyme inhibitorsDisease severityAligning quality and payment for heart failure care: Defining the challenges
Havranek EP, Krumholz HM, Dudley RA, Adams K, Gregory D, Lampert S, Lindenfeld J, Massie BM, Pina I, Restaino S, Rich MW, Konstam MA. Aligning quality and payment for heart failure care: Defining the challenges. Journal Of Cardiac Failure 2003, 9: 251-254. PMID: 13680543, DOI: 10.1054/jcaf.2003.30.Peer-Reviewed Original ResearchConceptsHigh-quality careQuality careHeart Failure SocietyHeart failure careHeart failure patientsQuality of careFailure patientsHeart failureReadmission ratesRecent roundtable discussionDisease severityInterests of patientsCarePatientsHospitalReimbursement systemReimbursement schemesEmpty bedsPhysicians