Sex-Based Differences in the Effect of Digoxin for the Treatment of Heart Failure
Rathore SS, Wang Y, Krumholz HM. Sex-Based Differences in the Effect of Digoxin for the Treatment of Heart Failure. New England Journal Of Medicine 2002, 347: 1403-1411. PMID: 12409542, DOI: 10.1056/nejmoa021266.Peer-Reviewed Original ResearchConceptsEffect of digoxinDepressed left ventricular systolic functionLeft ventricular systolic functionVentricular systolic functionSex-based differencesRate of deathDigoxin therapyHeart failureSystolic functionMultivariable Cox proportional hazards modelsDigitalis Investigation Group (DIG) studyDigitalis Investigation Group trialCox proportional hazards modelHeart failure variesPrimary end pointRisk of deathProportional hazards modelMantel-Haenszel testOverall mortalityTherapy differsEpidemiologic featuresMultivariable analysisClinical variablesSubgroup analysisGroup trials