2021
The association of neighborhood walkability with health outcomes in older adults after acute myocardial infarction: The SILVER-AMI study
Roy B, Hajduk AM, Tsang S, Geda M, Riley C, Krumholz HM, Chaudhry SI. The association of neighborhood walkability with health outcomes in older adults after acute myocardial infarction: The SILVER-AMI study. Preventive Medicine Reports 2021, 23: 101391. PMID: 34040930, PMCID: PMC8141908, DOI: 10.1016/j.pmedr.2021.101391.Peer-Reviewed Original ResearchAcute myocardial infarctionSILVER-AMI StudyPhysical activityMental healthMyocardial infarctionNeighborhood walkabilityOlder adultsHealth outcomesSocial supportCommunity-Living AdultsSecondary outcomesCoronary diseasePrimary outcomeSF-12Longitudinal cohortPhysical therapyAdjusted modelSurvival timeBetter outcomesGreater walkabilitySurvival analysisMobility limitationsPhysical healthOutcomesAdults
2019
Sex-Based Differences in Presentation, Treatment, and Complications Among Older Adults Hospitalized for Acute Myocardial Infarction
Nanna MG, Hajduk AM, Krumholz HM, Murphy TE, Dreyer RP, Alexander KP, Geda M, Tsang S, Welty FK, Safdar B, Lakshminarayan DK, Chaudhry SI, Dodson JA. Sex-Based Differences in Presentation, Treatment, and Complications Among Older Adults Hospitalized for Acute Myocardial Infarction. Circulation Cardiovascular Quality And Outcomes 2019, 12: e005691. PMID: 31607145, PMCID: PMC6913190, DOI: 10.1161/circoutcomes.119.005691.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAgedAged, 80 and overComorbidityDisability EvaluationFemaleHealth Status DisparitiesHealthcare DisparitiesHumansLife StyleMaleMyocardial RevascularizationNon-ST Elevated Myocardial InfarctionPatient AdmissionPrevalenceProspective StudiesRisk AssessmentRisk FactorsSex FactorsSocial Determinants of HealthST Elevation Myocardial InfarctionTime FactorsTreatment OutcomeUnited StatesConceptsAcute myocardial infarctionSex-based differencesPercutaneous coronary interventionFunctional impairmentOlder adultsHospital complicationsCoronary interventionOlder patientsCoronary diseaseMyocardial infarctionAge-related functional impairmentsAge-associated functional impairmentsLower ratesPrior coronary diseaseObstructive coronary diseaseProspective observational studyNSTEMI subgroupSTEMI subgroupUnderwent revascularizationAcute myocardialChest painClinical presentationAMI subgroupRisk factorsHigh prevalence
2017
Young Women With Acute Myocardial Infarction
Dreyer RP, Sciria C, Spatz ES, Safdar B, D'Onofrio G, Krumholz HM. Young Women With Acute Myocardial Infarction. Circulation Cardiovascular Quality And Outcomes 2017, 10: e003480. PMID: 28228455, PMCID: PMC5502480, DOI: 10.1161/circoutcomes.116.003480.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionYoung womenMyocardial infarctionManagement of AMIPost-AMI periodContinuum of careCoronary diseaseAged menHigh riskWorse recoveryWomenInfarctionHighlight gapsRecent studiesDifferent mechanismsMorbidityHospitalMortalityEpidemiologyPublic awarenessDiseaseDiagnosisCare
2016
Return to Work After Acute Myocardial Infarction
Dreyer RP, Xu X, Zhang W, Du X, Strait KM, Bierlein M, Bucholz EM, Geda M, Fox J, D'Onofrio G, Lichtman JH, Bueno H, Spertus JA, Krumholz HM. Return to Work After Acute Myocardial Infarction. Circulation Cardiovascular Quality And Outcomes 2016, 9: s45-s52. PMID: 26908859, PMCID: PMC4771977, DOI: 10.1161/circoutcomes.115.002611.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionMyocardial infarctionYoung AMI Patients (VIRGO) studyPrevious coronary diseaseYoung populationPatients' sociodemographic characteristicsSex differencesMedical record abstractionMultivariable regression analysisCoronary diseasePatient characteristicsYounger patientsRecord abstractionPatient interviewsHealth characteristicsPsychosocial factorsWorse recoverySociodemographic characteristicsHealth measuresGreater riskYoung womenPhysical healthPatient studiesHigher likelihoodYoung men
2014
Hospital Variation in the Use of Noninvasive Cardiac Imaging and Its Association With Downstream Testing, Interventions, and Outcomes
Safavi KC, Li SX, Dharmarajan K, Venkatesh AK, Strait KM, Lin H, Lowe TJ, Fazel R, Nallamothu BK, Krumholz HM. Hospital Variation in the Use of Noninvasive Cardiac Imaging and Its Association With Downstream Testing, Interventions, and Outcomes. JAMA Internal Medicine 2014, 174: 546-553. PMID: 24515551, PMCID: PMC5459406, DOI: 10.1001/jamainternmed.2013.14407.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionNoninvasive cardiac imagingDownstream testingReadmission ratesRevascularization proceduresCardiac imagingHospital variationCardiac ischemiaProportion of patientsNoninvasive imagingLower readmission ratesPrincipal discharge diagnosisCross-sectional studyCardiac biomarker testsQ4 hospitalsChest discomfortCoronary angiographyCoronary diseaseDischarge diagnosisCoronary angiogramEmergency departmentMyocardial infarctionSame hospitalCurrent guidelinesInpatient wards
2004
Predictors of cardiologist care for older patients hospitalized for heart failure
Foody JM, Rathore SS, Wang Y, Herrin J, Masoudi FA, Havranek EP, Radford MJ, Krumholz HM. Predictors of cardiologist care for older patients hospitalized for heart failure. American Heart Journal 2004, 147: 66-73. PMID: 14691421, DOI: 10.1016/j.ahj.2003.07.005.Peer-Reviewed Original ResearchConceptsHeart failureSpecialty careOlder patientsMultivariable hierarchical logistic regression modelsCoronary Artery Bypass GraftingChronic obstructive pulmonary diseasePercutaneous transluminal coronary angioplastyArtery Bypass GraftingHeart failure careObstructive pulmonary diseaseTransluminal coronary angioplastyHierarchical logistic regression modelsLogistic regression modelsCardiologist careBypass GraftingHospital factorsPatient characteristicsCardiology consultCoronary angioplastyCoronary diseasePulmonary diseaseClinical presentationCardiology carePatient raceMedicare patients
2001
Acute myocardial infarction in the elderly: differences by age
Mehta R, Rathore S, Radford M, Wang Y, Wang Y, Krumholz H. Acute myocardial infarction in the elderly: differences by age. Journal Of The American College Of Cardiology 2001, 38: 736-741. PMID: 11527626, DOI: 10.1016/s0735-1097(01)01432-2.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionAge-associated differencesElderly patientsClinical characteristicsAge groupsMyocardial infarctionThirty-day mortality rateMedicare beneficiaries ageOne-year mortalityPrior coronary diseaseProportion of patientsST-segment elevationOlder age groupsSignificant age-associated differencesChest painEffect of ageOlder patientsRenal insufficiencyCoronary diseaseHeart failureHospital admissionPatient characteristicsSuccessive age groupsSymptom onsetDiabetic patients
1998
Depression and Risk of Coronary Heart Disease in Elderly Men and Women: New Haven EPESE, 1982-1991
Mendes de Leon CF, Krumholz HM, Seeman TS, Vaccarino V, Williams CS, Kasl SV, Berkman LF. Depression and Risk of Coronary Heart Disease in Elderly Men and Women: New Haven EPESE, 1982-1991. JAMA Internal Medicine 1998, 158: 2341-2348. PMID: 9827785, DOI: 10.1001/archinte.158.21.2341.Peer-Reviewed Original ResearchMeSH KeywordsActivities of Daily LivingAge FactorsAgedCause of DeathCohort StudiesConnecticutCoronary DiseaseDeath CertificatesDepressionFemaleForecastingHospitalizationHumansIncidenceInterviews as TopicMaleMedical AuditMyocardial InfarctionOutcome Assessment, Health CarePatient AdmissionReproducibility of ResultsRisk FactorsSex FactorsSurvival RateConceptsCoronary heart diseaseCHD risk factorsDepressive symptomsRisk factorsCHD outcomesHeart diseaseAge-adjusted relative riskImpaired physical functionIncident coronary diseasePhysical function impairmentIncident CHD eventsNonfatal myocardial infarctionIndependent risk factorMedical chart reviewHealthy older womenCause of deathCHD deathCHD eventsCHD mortalityChart reviewCHD incidenceCoronary diseaseFunction impairmentPhysical functionElderly men
1993
Coronary revascularization after myocardial infarction in the very elderly: outcomes and long-term follow-up.
Krumholz HM, Forman DE, Kuntz RE, Baim DS, Wei JY. Coronary revascularization after myocardial infarction in the very elderly: outcomes and long-term follow-up. Annals Of Internal Medicine 1993, 119: 1084-90. PMID: 8239227, DOI: 10.7326/0003-4819-119-11-199312010-00005.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overCardiac CatheterizationContraindicationsFemaleFollow-Up StudiesHemodynamicsHospital MortalityHumansMaleMiddle AgedMultivariate AnalysisMyocardial InfarctionMyocardial RevascularizationProportional Hazards ModelsQuality of LifeRetrospective StudiesSurvival AnalysisTreatment OutcomeConceptsAcute myocardial infarctionCoronary revascularizationMyocardial infarctionElderly patientsComplicated acute myocardial infarctionConsecutive patients 80 yearsCoronary artery bypass surgeryTertiary care teaching hospitalCox proportional hazards modelMedical therapy groupPatients 80 yearsRetrospective cohort studyArtery bypass surgerySevere valvular diseaseSignificant coronary diseaseInvasive cardiovascular proceduresProportional hazards modelQuality of lifeAngioplasty groupSurgery groupBypass surgeryCohort studyCardiac catheterizationCoronary diseaseSerious complications