2024
Cost-effectiveness of bevacizumab therapy in the care of patients with hereditary hemorrhagic telangiectasia
Wang D, Ito S, Waldron C, Butt A, Zhang E, Krumholz H, Al-Samkari H, Goshua G. Cost-effectiveness of bevacizumab therapy in the care of patients with hereditary hemorrhagic telangiectasia. Blood Advances 2024, 8: 2835-2845. PMID: 38537061, PMCID: PMC11176968, DOI: 10.1182/bloodadvances.2024012589.Peer-Reviewed Original ResearchIncremental net monetary benefitHereditary hemorrhagic telangiectasiaStandard-of-careBevacizumab therapyWillingness-to-payNet monetary benefitHemorrhagic telangiectasiaWillingness-to-pay thresholdsStandard-of-care strategiesCare of patientsCost-effectiveness analysisAnti-VEGF bevacizumabSystemic antiangiogenic therapyCurrent standard-of-careMonetary benefitsTime horizonFormulary placementHealthcare resource utilizationStandard of careLifetime time horizonPatient quality-of-lifeScenario analysisProbabilistic sensitivity analysesIV bevacizumabAnti-VEGF
2023
Longitudinal Systemic Bevacizumab Therapy Produces Cost Savings and Improves Quality-Adjusted Life Expectancy in the Care of Patients with Hereditary Hemorrhagic Telangiectasia with Moderate-to-Severe Bleeding
Wang D, Ito S, Waldron C, Butt A, Zhang E, Krumholz H, Al-Samkari H, Goshua G. Longitudinal Systemic Bevacizumab Therapy Produces Cost Savings and Improves Quality-Adjusted Life Expectancy in the Care of Patients with Hereditary Hemorrhagic Telangiectasia with Moderate-to-Severe Bleeding. Blood 2023, 142: 2312. DOI: 10.1182/blood-2023-185340.Peer-Reviewed Original ResearchHereditary hemorrhagic telangiectasiaIncremental net monetary benefitIncremental cost-effectiveness ratioEmergency department visitsCare of patientsHemostatic proceduresIron infusionPatient timeBevacizumab therapyDepartment visitsRBC transfusionHemorrhagic telangiectasiaVascular endothelial growth factor inhibitionRed blood cell transfusionEQ-5D index valuesCommon hereditary bleeding disorderLocal hemostatic proceduresRBC transfusion needSystemic bevacizumab therapyHealth resource utilizationBlood cell transfusionWorld Health Organization VigiBaseLong-term followGrowth factor inhibitionCost-saving intervention
2017
The State of the Science on Integrating Palliative Care in Heart Failure
Gelfman L, Bakitas M, Warner Stevenson L, Kirkpatrick J, Goldstein N, Ahluwalia S, Allen L, Allen K, Arnold B, Bakitas M, Bekelman D, Buck H, Dionne-Odom J, Dougherty C, Dunbar S, Evangelista L, Fahlberg B, Fendler T, Gelfman L, Goldstein N, Hanson L, Hauptman P, Karlekar M, Kavalieratos D, Kirkpatrick J, Kirkwood P, Kono A, Krumholz H, Kutner J, Lala A, Lindenfeld J, Mancarella G, Matlock D, Matzo M, Maurer M, Morrison S, O'Donnell A, Pamboukian S, Pinney S, Prince S, Reigel B, Ritchie C, Rogers J, Spertus J, Steinhauser K, Stevenson L, Strömberg A, Sudore R, Swetz K, Teuteberg W, Teuteberg J, Tucker R, Tulsky J, Wiegand D. The State of the Science on Integrating Palliative Care in Heart Failure. Journal Of Palliative Medicine 2017, 20: 592-603. PMID: 29493362, PMCID: PMC5455612, DOI: 10.1089/jpm.2017.0178.Peer-Reviewed Original ResearchConceptsHeart failurePalliative careUncontrolled symptomsIntegrating Palliative CarePalliative care integrationAdvanced heart failureAdvanced HF patientsChronic progressive illnessLife-prolonging therapiesCare of patientsAdvance care planningQuality of careQuality of lifeHF diseaseHF patientsHealthcare utilizationProgressive illnessHF populationHigh morbidityInterdisciplinary careInterdisciplinary working groupCare planningLife careCurrent evidenceFamily caregivers
2011
Trends in Comorbidity, Disability, and Polypharmacy in Heart Failure
Wong CY, Chaudhry SI, Desai MM, Krumholz HM. Trends in Comorbidity, Disability, and Polypharmacy in Heart Failure. The American Journal Of Medicine 2011, 124: 136-143. PMID: 21295193, PMCID: PMC3237399, DOI: 10.1016/j.amjmed.2010.08.017.Peer-Reviewed Original ResearchConceptsProportion of patientsHeart failureSelf-reported heart failureHeart failure populationComorbid chronic conditionsNumber of comorbiditiesNutrition Examination SurveyCare of patientsPrevalence of disabilityPhenotype of patientsComplexity of patientsMedication useRecent patientsFunctional disabilityExamination SurveyFailure populationPhysical functionPrescription medicationsPatient preferencesChronic conditionsNational HealthPatient's abilityComorbiditiesPatientsOlder individuals
2008
Consequences of Inadequate Sign-out for Patient Care
Horwitz LI, Moin T, Krumholz HM, Wang L, Bradley EH. Consequences of Inadequate Sign-out for Patient Care. JAMA Internal Medicine 2008, 168: 1755-1760. PMID: 18779462, DOI: 10.1001/archinte.168.16.1755.Peer-Reviewed Original ResearchConceptsHealth care providersClinical conditionsCare providersIntensive care unit transferPatient's clinical conditionCare of patientsHouse staff teamsAdverse eventsImportant adverse consequencesCase reportClinical informationAnticipatory guidancePatientsPatient careUnit transferIterative coding processHouse staffAdverse consequencesSignsCareDaysSessionsProvidersDiagnosisRecipients
2007
Randomized Trial of Telemonitoring to Improve Heart Failure Outcomes (Tele-HF): Study Design
Chaudhry SI, Barton B, Mattera J, Spertus J, Krumholz HM. Randomized Trial of Telemonitoring to Improve Heart Failure Outcomes (Tele-HF): Study Design. Journal Of Cardiac Failure 2007, 13: 709-714. PMID: 17996818, PMCID: PMC2702538, DOI: 10.1016/j.cardfail.2007.06.720.Peer-Reviewed Case Reports and Technical NotesConceptsHeart failure outcomesHeart failureClinical statusFailure outcomesDecompensated heart failureHeart failure decompensationCare of patientsPrimary care practicesSelf-reported weightUsual careHospital readmissionDaily symptomsRandomized trialsGeneral cardiologyPatient participationHealth behaviorsCare practicesPatientsFrequent monitoringFavorable effectInterventionOutcomesSymptomsTrialsCareMeasuring Performance For Treating Heart Attacks And Heart Failure: The Case For Outcomes Measurement
Krumholz HM, Normand SL, Spertus JA, Shahian DM, Bradley EH. Measuring Performance For Treating Heart Attacks And Heart Failure: The Case For Outcomes Measurement. Health Affairs 2007, 26: 75-85. PMID: 17211016, DOI: 10.1377/hlthaff.26.1.75.Peer-Reviewed Original Research
2003
National trends in the care of patients with heart failure, 1998–2001: Results from the CMS National heart failure project
Masoudi F, Stevens B, Foody J, Havranek E, Krumholz H, Ordin D. National trends in the care of patients with heart failure, 1998–2001: Results from the CMS National heart failure project. Journal Of The American College Of Cardiology 2003, 41: 518. DOI: 10.1016/s0735-1097(03)82792-4.Peer-Reviewed Original Research
2002
β-Blocker Therapy in Heart Failure: Scientific Review
Foody JM, Farrell MH, Krumholz HM. β-Blocker Therapy in Heart Failure: Scientific Review. JAMA 2002, 287: 883-889. PMID: 11851582, DOI: 10.1001/jama.287.7.883.Peer-Reviewed Original ResearchConceptsHeart failure patientsHeart failureClinical trialsFailure patientsClinical outcomesClass IIDrug Administration indicationsBeta-blocker usePrimary end pointΒ-blocker therapyScientific rationaleTreatment of patientsCare of patientsEnglish-language articlesPotential physiologic roleBasic science studiesClass of agentsSystolic dysfunctionMortality benefitPlacebo treatmentDATA EXTRACTIONClinical guidelinesSTUDY SELECTIONCurrent recommendationsPatients
2000
Medicare Initiatives to Improve Heart Failure Care: An Introduction
Ordin D, Masoudi F, Havranek E, Krumholz H. Medicare Initiatives to Improve Heart Failure Care: An Introduction. Congestive Heart Failure 2000, 6: 280-282. PMID: 12189290, DOI: 10.1111/j.1527-5299.2000.80166.x.Peer-Reviewed Original ResearchHeart failure patientsHeart failureFailure patientsHeart Failure Practice Improvement EffortCommon discharge diagnosesLittle national informationOutcomes of patientsHeart failure careHealth careCare of patientsPractice improvement effortsQuality improvement projectContinuum of careHealth care professionalsHealth Care Financing AdministrationQuality of careQuality improvement effortsGuideline recommendationsDischarge diagnosisInpatient careMedicare beneficiariesCare professionalsPatientsImprovement effortsCareWhat's Happening in Quality Improvement at the Local Hospital: A State Wide Study From the Cooperative Cardiovascular Project
Holmboe E, Meehan T, Radford M, Wang Y, Krumholz H. What's Happening in Quality Improvement at the Local Hospital: A State Wide Study From the Cooperative Cardiovascular Project. American Journal Of Medical Quality 2000, 15: 106-113. PMID: 10872260, DOI: 10.1177/106286060001500304.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionCooperative Cardiovascular ProjectFull-time equivalentsAMI careNonfederal hospitalsIndividual hospitalsCare of patientsProcess of careMultidisciplinary QI teamQuality of careQuality improvement activitiesMyocardial infarctionLocal hospitalImprovement interventionsHospitalRegistered NursesSecondary analysisPhysician championsQI teamsCareScientific evidenceState-wide studyCritical pathwaysQuestionnaire studyDepartment
1999
Use of critical pathways to improve the care of patients with acute myocardial infarction11Dr. Krumholz is a Paul Beeson Faculty Scholar. This article was written by CDR Eric S. Holmboe while a fellow in the Robert Wood Johnson Clinical Scholars Program, Yale University School of Medicine. The views expressed in this article are those of the author and do not reflect the official policy or position of the Department of the Navy, Department of Defense, nor the U.S. Government.
Holmboe E, Meehan T, Radford M, Wang Y, Marciniak T, Krumholz H. Use of critical pathways to improve the care of patients with acute myocardial infarction11Dr. Krumholz is a Paul Beeson Faculty Scholar. This article was written by CDR Eric S. Holmboe while a fellow in the Robert Wood Johnson Clinical Scholars Program, Yale University School of Medicine. The views expressed in this article are those of the author and do not reflect the official policy or position of the Department of the Navy, Department of Defense, nor the U.S. Government. The American Journal Of Medicine 1999, 107: 324-331. PMID: 10527033, DOI: 10.1016/s0002-9343(99)00239-9.Peer-Reviewed Original ResearchConceptsLength of stayEvidence-based medical therapyProportion of patientsMyocardial infarctionMedical therapyMedicare patientsMain endpointCritical pathwaysAngiotensin-converting enzyme inhibitorAcute myocardial infarctionCare of patientsLongitudinal cohort studyProcess of careFirst dayQuality of careCross-sectional analysisReperfusion therapyCohort studyPrincipal diagnosisConnecticut hospitalsPatientsEnzyme inhibitorsYale University SchoolStayClinical Scholars Program
1998
Trends in the Quality of Care for Medicare Beneficiaries Admitted to the Hospital With Unstable Angina
Krumholz H, Philbin D, Wang Y, Vaccarino V, Murillo J, Therrien M, Williams J, Radford M. Trends in the Quality of Care for Medicare Beneficiaries Admitted to the Hospital With Unstable Angina. Journal Of The American College Of Cardiology 1998, 31: 957-963. PMID: 9561993, DOI: 10.1016/s0735-1097(98)00106-5.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAngina, UnstableAnticoagulantsAspirinConnecticutFemaleGuideline AdherenceHeparinHospitalsHumansMaleMedicarePlatelet Aggregation InhibitorsPractice Guidelines as TopicQuality Indicators, Health CareQuality of Health CareRetrospective StudiesSurvival AnalysisUnited StatesConceptsUse of aspirinUnstable anginaElderly patientsConsecutive patientsHospital admissionRetrospective cohort studyPrincipal discharge diagnosisPatterns of treatmentCare of patientsGuideline-based useQuality of careHealth care policyAHCPR guidelinesChest painHospital dischargeCohort studyMedical chartsPatient factorsDischarge diagnosisPatient outcomesPractice patternsConnecticut hospitalsPractice guidelinesAnginaMedicare beneficiaries
1997
Reporting ejection fraction after myocardial infarction: an opportunity for quality improvement in echocardiography.
Goldberg DJ, Radford MJ, Krumholz HM. Reporting ejection fraction after myocardial infarction: an opportunity for quality improvement in echocardiography. Connecticut Medicine 1997, 61: 143-5. PMID: 9097485.Peer-Reviewed Original ResearchConceptsMyocardial infarctionEjection fractionLeft ventricular ejection fractionVentricular ejection fractionVentricular systolic functionAcute myocardial infarctionCare of patientsSystolic functionVentricular functionEchocardiography studyMedicare beneficiariesInfarctionEchocardiographyReportPrincipal findingsA collaborative project in Connecticut to improve the care of patients with acute myocardial infarction.
Meehan TP, Radford MJ, Vaccarino LV, Gottlieb LD, McGovern-Hughes B, Herman MV, Revkin JH, Therrien ML, Petrillo MK, Krumholz HM. A collaborative project in Connecticut to improve the care of patients with acute myocardial infarction. Connecticut Medicine 1997, 61: 147-55. PMID: 9097486.Peer-Reviewed Original ResearchConceptsConnecticut Peer Review OrganizationPeer review organizationsCare of patientsAcute myocardial infarction careChart abstraction toolUse of thrombolyticsAcute myocardial infarctionMyocardial infarction careStaff education sessionsNon-Medicare patientsBeta blockersAtrial fibrillationAppropriate medicationEmergency departmentMyocardial infarctionQI interventionsLocal hospitalImprovement interventionsEducation sessionsHospitalQI planPatientsIndividual hospitalsQI activitiesQI project
1996
A Collaborative Project in Connecticut to Improve the Care of Patients with Acute Myocardial Infarction
Meehan T, Radford M, Vaccarino L, Gottlieb L, McGovern-Hughes B, Herman M, Revkin J, Therrien M, Petrillo M, Krumholz H. A Collaborative Project in Connecticut to Improve the Care of Patients with Acute Myocardial Infarction. The Joint Commission Journal On Quality And Patient Safety 1996, 22: 751-761. PMID: 8937949, DOI: 10.1016/s1070-3241(16)30280-2.Peer-Reviewed Original ResearchConceptsConnecticut Peer Review OrganizationPeer review organizationsCare of patientsAcute myocardial infarction careChart abstraction toolUse of thrombolyticsAcute myocardial infarctionMyocardial infarction careStaff education sessionsNon-Medicare patientsBeta blockersAtrial fibrillationAppropriate medicationEmergency departmentMyocardial infarctionQI interventionsLocal hospitalImprovement interventionsEducation sessionsHospitalQI planPatientsIndividual hospitalsQI activitiesQI project
1995
Health maintenance organizations, fee for service and the care of patients with acute myocardial infarction
Krumholz H. Health maintenance organizations, fee for service and the care of patients with acute myocardial infarction. Journal Of The American College Of Cardiology 1995, 26: 407-408. PMID: 7608442, DOI: 10.1016/0735-1097(95)80014-8.Peer-Reviewed Original Research