2022
Efficacy and Safety Considerations With Dose-Reduced Direct Oral Anticoagulants
Bikdeli B, Tajrishi F, Sadeghipour P, Talasaz AH, Fanikos J, Lippi G, Siegal DM, Eikelboom JW, Monreal M, Jimenez D, Connors JM, Ageno W, Barnes GD, Piazza G, Angiolillo DJ, Parikh SA, Kirtane AJ, Lopes RD, Bhatt DL, Weitz JI, Mehran R, Krumholz HM, Goldhaber SZ, Lip GYH. Efficacy and Safety Considerations With Dose-Reduced Direct Oral Anticoagulants. JAMA Cardiology 2022, 7: 747-759. PMID: 35648414, DOI: 10.1001/jamacardio.2022.1292.Peer-Reviewed Original ResearchConceptsDirect oral anticoagulantsRandomized clinical trialsAcute VTE treatmentDose adjustmentOral anticoagulantsLow-intensity treatmentPrimary preventionLarge registriesVTE treatmentHigh-risk medical patientsStable atherosclerotic vascular diseaseHigh-risk cancer patientsLarge randomized clinical trialsSecondary VTE preventionPeripheral artery diseaseAtherosclerotic vascular diseaseDaily clinical practiceRoutine practice patternEvidence of safetyRecent revascularizationStroke preventionVTE preventionArtery diseaseMedical patientsCancer patients
2012
Appropriate And Inappropriate Imaging Rates For Prostate Cancer Go Hand In Hand By Region, As If Set By Thermostat
Makarov DV, Desai R, Yu JB, Sharma R, Abraham N, Albertsen PC, Krumholz HM, Penson DF, Gross CP. Appropriate And Inappropriate Imaging Rates For Prostate Cancer Go Hand In Hand By Region, As If Set By Thermostat. Health Affairs 2012, 31: 730-740. PMID: 22492890, DOI: 10.1377/hlthaff.2011.0336.Peer-Reviewed Original ResearchConceptsInappropriate imagingAppropriate imagingProstate cancerHigh-risk prostate cancerHigh rateHigh-risk patientsHealth care utilizationProstate cancer patientsCross-sectional studyOverall imaging rateHealth care costsLower ratesCare utilizationCancer patientsAppropriate treatmentAdvanced imagingCare costsPatientsHealth care organizationsCare organizationsCancerCost containmentImagingImaging rateRegional variation
2008
Cerebrovascular Disease Risk in Older Head and Neck Cancer Patients After Radiotherapy
Smith GL, Smith BD, Buchholz TA, Giordano SH, Garden AS, Woodward WA, Krumholz HM, Weber RS, Ang K, Rosenthal DI. Cerebrovascular Disease Risk in Older Head and Neck Cancer Patients After Radiotherapy. Journal Of Clinical Oncology 2008, 26: 5119-5125. PMID: 18725647, PMCID: PMC4879715, DOI: 10.1200/jco.2008.16.6546.Peer-Reviewed Original ResearchConceptsCerebrovascular disease riskNeck cancer patientsDisease riskCerebrovascular eventsCerebrovascular riskCardiac riskCancer patientsNeck cancerTreatment groupsTen-year incidenceProportional hazards regressionDefinitive radiotherapyPostoperative radiotherapyCardiac eventsOlder patientsCerebrovascular diseaseHazards regressionNonmetastatic headMean ageVascular diseaseBaseline riskPatientsSurgeryRadiotherapyControl diagnosis
2007
The Impact of Venous Thromboembolism on Risk of Death or Hemorrhage in Older Cancer Patients
Gross CP, Galusha DH, Krumholz HM. The Impact of Venous Thromboembolism on Risk of Death or Hemorrhage in Older Cancer Patients. Journal Of General Internal Medicine 2007, 22: 321-326. PMID: 17356962, PMCID: PMC1824718, DOI: 10.1007/s11606-006-0019-x.Peer-Reviewed Original ResearchConceptsRisk of deathOlder cancer patientsConcomitant venous thromboembolismVenous thromboembolismMajor hemorrhageCancer patientsCancer typesCancer diagnosisMedicare administrative claims dataPrevalence of VTEEnd Results cancer registryRetrospective cohort studyAdministrative claims dataCohort studyCancer RegistryInvasive cancerExcess riskMost cancer typesCancer stageClaims dataHemorrhagePatientsSociodemographic factorsPotential mediatorsDeath
2005
The impact of socioeconomic status and race on trial participation for older women with breast cancer
Gross CP, Filardo G, Mayne ST, Krumholz HM. The impact of socioeconomic status and race on trial participation for older women with breast cancer. Cancer 2005, 103: 483-491. PMID: 15597407, DOI: 10.1002/cncr.20792.Peer-Reviewed Original ResearchMeSH KeywordsAgedAsianBlack or African AmericanBreast NeoplasmsCase-Control StudiesClinical Trials as TopicFemaleHispanic or LatinoHumansLogistic ModelsMedicaidMultivariate AnalysisNational Institutes of Health (U.S.)Odds RatioPatient SelectionPovertySEER ProgramUnemploymentUnited StatesWhite PeopleConceptsBreast cancer trialsTrial participationOlder womenBreast cancerSocioeconomic statusMedicaid insuranceTrial enrollmentCancer patientsCancer trialsMultivariable logistic regression modelBreast cancer patientsMedicaid insurance coverageAssociation of SESHigh-poverty zip codesCase-control studyPopulation-based sampleLow socioeconomic statusLogistic regression modelsImpact of SESWhite patientsBlack patientsSEER areasBlack raceElderly womenTrial participants
2004
Cancer Trial Enrollment After State-Mandated Reimbursement
Gross CP, Murthy V, Li Y, Kaluzny AD, Krumholz HM. Cancer Trial Enrollment After State-Mandated Reimbursement. Journal Of The National Cancer Institute 2004, 96: 1063-1069. PMID: 15265967, DOI: 10.1093/jnci/djh193.Peer-Reviewed Original ResearchMeSH KeywordsBreast NeoplasmsClinical Trials, Phase II as TopicClinical Trials, Phase III as TopicColorectal NeoplasmsFemaleGovernment RegulationHumansIncidenceLogistic ModelsLongitudinal StudiesLung NeoplasmsMaleMulticenter Studies as TopicNational Institutes of Health (U.S.)NeoplasmsPatient SelectionPoisson DistributionProstatic NeoplasmsReimbursement MechanismsRetrospective StudiesState GovernmentUnited StatesConceptsCancer trial enrollmentTrial enrollment ratesTrial enrollmentMultivariable analysisTrial participationOdds ratioTrial participantsCoverage policiesCancer trial participantsCooperative group trialsClinical trial enrollmentEarly phase trialsRecruitment of patientsCancer trial participationMedical care costsPhase II trial participantsCancer patientsPhase trialsCancer research studiesGroup trialsCare costsPoisson regressionCancer typesReimbursement policiesPhase II