2022
Identifying quality of life outcome patterns to inform treatment choices in ischemic cardiomyopathy
Mori M, Mark DB, Khera R, Lin H, Jones P, Huang C, Lu Y, Geirsson A, Velazquez EJ, Spertus JA, Krumholz HM. Identifying quality of life outcome patterns to inform treatment choices in ischemic cardiomyopathy. American Heart Journal 2022, 254: 12-22. PMID: 35932911, DOI: 10.1016/j.ahj.2022.07.007.Peer-Reviewed Original ResearchConceptsCoronary artery bypass surgeryGuideline-directed medical therapyTreatment choiceBetter outcomesIschemic cardiomyopathyQOL outcomesQoL dataKansas City Cardiomyopathy Questionnaire overall summary scoreQOL trajectoriesOutcome patternsIschemic Heart Failure (STICH) trialHeart Failure TrialMain baseline predictorsArtery bypass surgeryOverall summary scoreDifferent treatment choicesLogistic regression modelsBypass surgeryMedical therapySurgical treatmentFailure TrialLife scoresQOL scoresPatient's probabilityBaseline predictors
2013
Hospital-Based, Acute Care Use Among Patients Within 30 Days of Discharge After Coronary Artery Bypass Surgery
Fox JP, Suter LG, Wang K, Wang Y, Krumholz HM, Ross JS. Hospital-Based, Acute Care Use Among Patients Within 30 Days of Discharge After Coronary Artery Bypass Surgery. The Annals Of Thoracic Surgery 2013, 96: 96-104. PMID: 23702228, PMCID: PMC3758868, DOI: 10.1016/j.athoracsur.2013.03.091.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overCaliforniaCoronary Artery BypassCoronary Artery DiseaseEmergency Service, HospitalFemaleFollow-Up StudiesHumansIntensive Care UnitsLength of StayLinear ModelsMaleMiddle AgedMorbidityPatient DischargePatient ReadmissionPostoperative ComplicationsPostoperative PeriodPrognosisRecurrenceRetrospective StudiesRisk FactorsSurvival RateTime FactorsYoung AdultConceptsDays of dischargeAcute care needsCABG surgeryED visit ratesED visitsHospital readmissionReadmission ratesCare needsCoronary artery bypass graft surgeryVisit ratesArtery bypass graft surgeryCoronary artery bypass surgeryRisk-standardized readmission ratesAcute care ratesHospital 30 daysBypass graft surgeryAcute care useArtery bypass surgeryCongestive heart failureEmergency department visitsEmergency Department DatabasesChest discomfortGraft surgeryBypass surgeryHospital volume
2006
Impact of Chronic Kidney Disease on Health-Related Quality-of-Life Improvement After Coronary Artery Bypass Surgery
Parikh CR, Coca SG, Smith GL, Vaccarino V, Krumholz HM. Impact of Chronic Kidney Disease on Health-Related Quality-of-Life Improvement After Coronary Artery Bypass Surgery. JAMA Internal Medicine 2006, 166: 2014-2019. PMID: 17030836, DOI: 10.1001/archinte.166.18.2014.Peer-Reviewed Original ResearchConceptsSevere chronic kidney diseaseChronic kidney diseasePhysical functionMH scorePF scoresKidney diseaseMedical Outcomes Trust Short FormAdvanced chronic kidney diseaseCoronary artery bypass surgeryLife outcomesCoronary artery bypassPrimary end pointArtery bypass surgeryHealth-related qualityCoronary artery diseaseMH subscalesArtery bypassCKD stageBypass surgeryArtery diseaseHealth SurveyMean changeStage 0Mean decreaseCABGPrevalence and Predictors of Angina Pectoris One Month After Myocardial Infarction
Spertus JA, Dawson J, Masoudi FA, Krumholz HM, Reid KJ, Peterson ED, Rumsfeld JS, Consortium C. Prevalence and Predictors of Angina Pectoris One Month After Myocardial Infarction. The American Journal Of Cardiology 2006, 98: 282-288. PMID: 16860010, DOI: 10.1016/j.amjcard.2006.01.099.Peer-Reviewed Original ResearchConceptsAngina pectorisMyocardial infarctionCoronary artery bypass surgeryPrevious coronary artery bypassMultivariable logistic regression analysisPatient's myocardial infarctionCoronary artery bypassSeattle Angina QuestionnaireArtery bypass surgeryLogistic regression analysisQuality of lifeIndex admissionAngina QuestionnaireArtery bypassIndex hospitalizationBypass surgeryYounger patientsTreatable symptomsTreatment characteristicsPatientsOne monthAdditional treatmentMonthsInfarctionRegression analysisRecursive partitioning–based preoperative risk stratification for atrial fibrillation after coronary artery bypass surgery
Sedrakyan A, Zhang H, Treasure T, Krumholz HM. Recursive partitioning–based preoperative risk stratification for atrial fibrillation after coronary artery bypass surgery. American Heart Journal 2006, 151: 720-724. PMID: 16504639, DOI: 10.1016/j.ahj.2005.05.010.Peer-Reviewed Original ResearchConceptsCoronary artery bypass graft surgeryAtrial fibrillationLow-risk groupAggressive prophylaxisRelative riskPredictors of AFArtery bypass graft surgeryCoronary artery bypass surgeryRisk of AFYale-New Haven HospitalOnly ejection fractionPreoperative atrial fibrillationBypass graft surgeryArtery bypass surgeryCoronary artery diseasePreoperative risk stratificationHigh-risk groupHeart disease severityPossible adverse eventsOlder age subgroupsArrhythmia prophylaxisGraft surgeryProphylactic therapyAdverse eventsBypass surgery
2005
Patients With Depressive Symptoms Have Lower Health Status Benefits After Coronary Artery Bypass Surgery
Mallik S, Krumholz HM, Lin ZQ, Kasl SV, Mattera JA, Roumains SA, Vaccarino V. Patients With Depressive Symptoms Have Lower Health Status Benefits After Coronary Artery Bypass Surgery. Circulation 2005, 111: 271-277. PMID: 15655132, DOI: 10.1161/01.cir.0000152102.29293.d7.Peer-Reviewed Original ResearchConceptsPhysical component scalePhysical functionGeriatric Depression ScaleGDS scoresDepressive symptomsPCS scoresRisk factorsFunctional improvementShort-Form 36 physical component scaleCoronary artery bypass surgeryHealth status benefitsInverse risk factorTime of CABGPatients' physical functionArtery bypass surgeryHistory of diabetesVentricular ejection fractionWorse physical functionCoronary artery diseaseIndependent prognostic factorPrevious myocardial infarctionStrong risk factorBaseline PCS scoresHigher GDS scoresSignificant independent predictors
2003
Sex Differences in Health Status After Coronary Artery Bypass Surgery
Vaccarino V, Lin ZQ, Kasl SV, Mattera JA, Roumanis SA, Abramson JL, Krumholz HM. Sex Differences in Health Status After Coronary Artery Bypass Surgery. Circulation 2003, 108: 2642-2647. PMID: 14597590, DOI: 10.1161/01.cir.0000097117.28614.d8.Peer-Reviewed Original ResearchConceptsPhysical functionMental healthReadmission ratesFunctional gainsCoronary artery bypass graft surgeryArtery bypass graft surgeryCoronary artery bypass surgeryLower functional gainsBypass graft surgeryArtery bypass surgeryHigher readmission ratesMan 6 monthsMean score improvementFirst CABGCABG surgeryGraft surgeryBaseline characteristicsBypass surgeryHospital readmissionMultivariable analysisAdverse outcomesFunctional statusFunctional improvementHealth SurveyHealth statusGender differences in recovery after coronary artery bypass surgery
Vaccarino V, Lin ZQ, Kasl SV, Mattera JA, Roumanis SA, Abramson JL, Krumholz HM. Gender differences in recovery after coronary artery bypass surgery. Journal Of The American College Of Cardiology 2003, 41: 307-314. PMID: 12535827, DOI: 10.1016/s0735-1097(02)02698-0.Peer-Reviewed Original ResearchConceptsPhysical functionCABG surgeryDepressive symptomsHospital readmissionCoronary artery bypass graft surgeryArtery bypass graft surgeryCoronary artery bypass surgeryBypass graft surgeryArtery bypass surgeryCongestive heart failureLow physical functionMore depressive symptomsFirst CABGGraft surgeryBaseline characteristicsBypass surgeryPatient characteristicsHeart failureIllness severityMedical recordsWorse outcomesClinical dataFemale genderHigh riskSide effects
2000
Are β-Blockers Effective in Elderly Patients Who Undergo Coronary Revascularization After Acute Myocardial Infarction?
Chen J, Radford MJ, Wang Y, Marciniak TA, Krumholz HM. Are β-Blockers Effective in Elderly Patients Who Undergo Coronary Revascularization After Acute Myocardial Infarction? JAMA Internal Medicine 2000, 160: 947-952. PMID: 10761959, DOI: 10.1001/archinte.160.7.947.Peer-Reviewed Original ResearchConceptsCoronary artery bypass surgeryPercutaneous transluminal coronary angioplastyBeta-blocker therapyAcute myocardial infarctionNonrevascularized groupCoronary revascularizationElderly patientsMyocardial infarctionNon-revascularized groupArtery bypass surgeryTransluminal coronary angioplastyClinical practice guidelinesCooperative Cardiovascular ProjectRandomized clinical trialsAmerican Heart AssociationBypass surgerySuccessful revascularizationClinical factorsCoronary angioplastyHeart AssociationPotential confoundersClinical trialsPractice guidelinesRevascularizationAmerican College
1993
Coronary revascularization after myocardial infarction in the very elderly: outcomes and long-term follow-up.
Krumholz HM, Forman DE, Kuntz RE, Baim DS, Wei JY. Coronary revascularization after myocardial infarction in the very elderly: outcomes and long-term follow-up. Annals Of Internal Medicine 1993, 119: 1084-90. PMID: 8239227, DOI: 10.7326/0003-4819-119-11-199312010-00005.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overCardiac CatheterizationContraindicationsFemaleFollow-Up StudiesHemodynamicsHospital MortalityHumansMaleMiddle AgedMultivariate AnalysisMyocardial InfarctionMyocardial RevascularizationProportional Hazards ModelsQuality of LifeRetrospective StudiesSurvival AnalysisTreatment OutcomeConceptsAcute myocardial infarctionCoronary revascularizationMyocardial infarctionElderly patientsComplicated acute myocardial infarctionConsecutive patients 80 yearsCoronary artery bypass surgeryTertiary care teaching hospitalCox proportional hazards modelMedical therapy groupPatients 80 yearsRetrospective cohort studyArtery bypass surgerySevere valvular diseaseSignificant coronary diseaseInvasive cardiovascular proceduresProportional hazards modelQuality of lifeAngioplasty groupSurgery groupBypass surgeryCohort studyCardiac catheterizationCoronary diseaseSerious complications
1992
Selection of patients for coronary angiography and coronary revascularization early after myocardial infarction: is there evidence for a gender bias?
Krumholz HM, Douglas PS, Lauer MS, Pasternak RC. Selection of patients for coronary angiography and coronary revascularization early after myocardial infarction: is there evidence for a gender bias? Annals Of Internal Medicine 1992, 116: 785-90. PMID: 1567092, DOI: 10.7326/0003-4819-116-10-785.Peer-Reviewed Original ResearchMeSH KeywordsAdultAge FactorsAgedAged, 80 and overAngioplasty, Balloon, CoronaryCardiac CatheterizationCoronary AngiographyCoronary Artery BypassFemaleHospitalizationHumansMaleMiddle AgedMyocardial InfarctionMyocardial RevascularizationOdds RatioPatient SelectionPrejudiceReferral and ConsultationRetrospective StudiesSeverity of Illness IndexSex FactorsVentricular Function, LeftConceptsCoronary artery diseaseSelection of patientsMyocardial infarctionCoronary angiographyArtery diseaseCoronary artery bypass graft surgeryArtery bypass graft surgeryCoronary artery bypass surgerySevere coronary artery diseasePercutaneous transluminal coronary angioplastyCreatine kinase MB fractionTertiary care teaching hospitalThree-vessel diseaseTwo-vessel diseaseArtery bypass surgeryBypass graft surgeryLeft main stenosisRetrospective cohort studyTransluminal coronary angioplastyPrincipal discharge diagnosisAcute myocardial infarctionAbnormal ejection fractionAge-adjusted ratesTherapeutic cardiovascular proceduresCoronary revascularization