2005
Adoption of Spironolactone Therapy for Older Patients With Heart Failure and Left Ventricular Systolic Dysfunction in the United States, 1998–2001
Masoudi FA, Gross CP, Wang Y, Rathore SS, Havranek EP, Foody JM, Krumholz HM. Adoption of Spironolactone Therapy for Older Patients With Heart Failure and Left Ventricular Systolic Dysfunction in the United States, 1998–2001. Circulation 2005, 112: 39-47. PMID: 15983243, DOI: 10.1161/circulationaha.104.527549.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overCohort StudiesCreatinineDiureticsDrug PrescriptionsFemaleFollow-Up StudiesHeart FailureHumansMaleMineralocorticoid Receptor AntagonistsPatient SelectionPotassiumRandomized Controlled Trials as TopicRisk AssessmentSpironolactoneUnited StatesVentricular Dysfunction, LeftConceptsRandomized Aldactone Evaluation StudyPublication of RALESVentricular systolic dysfunctionHeart failureEnrollment criteriaSpironolactone prescriptionSpironolactone therapySystolic dysfunctionOlder patientsLeft ventricular systolic dysfunctionPatients meeting enrollment criteriaSerial cross-sectional samplesSevere renal dysfunctionSerum creatinine valuesAldactone Evaluation StudyMultivariable logistic regressionSerum potassium valuesSkilled nursing facilitiesNoncardiovascular comorbiditiesSpironolactone useRenal dysfunctionAdverse eventsHospital dischargeAppropriate patientsMultivariable analysis
1997
Quality of Care for Elderly Patients Hospitalized With Heart Failure
Krumholz HM, Wang Y, Parent EM, Mockalis J, Petrillo M, Radford MJ. Quality of Care for Elderly Patients Hospitalized With Heart Failure. JAMA Internal Medicine 1997, 157: 2242-2247. PMID: 9343001, DOI: 10.1001/archinte.1997.00440400092011.Peer-Reviewed Original ResearchConceptsHeart failureQuality of careEnzyme inhibitorsElderly patientsClinical practiceResearch Clinical Practice GuidelinesLeft ventricular ejection fractionLeft ventricular systolic functionRetrospective medical record reviewAngiotensin-converting enzyme inhibitorSevere aortic stenosisPercentage of patientsVentricular systolic functionMedical record reviewVentricular ejection fractionClinical practice guidelinesPrincipal discharge diagnosisAcute care hospitalsActual clinical practiceHealth care policyChart reviewSystolic functionAortic stenosisAppropriate patientsCare hospitalDeterminants of Appropriate Use of Angiotensin-Converting Enzyme Inhibitors After Acute Myocardial Infarction in Persons ≥65 Years of Age
Krumholz H, Vaccarino V, Ellerbeck E, Kiefe C, Hennen J, Kresowik T, Gold J, Jencks S, Radford M. Determinants of Appropriate Use of Angiotensin-Converting Enzyme Inhibitors After Acute Myocardial Infarction in Persons ≥65 Years of Age. The American Journal Of Cardiology 1997, 79: 581-586. PMID: 9068512, DOI: 10.1016/s0002-9149(96)00819-3.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAlabamaAngiotensin-Converting Enzyme InhibitorsConnecticutContraindicationsControlled Clinical Trials as TopicDecision MakingDiabetes ComplicationsDiureticsDrug PrescriptionsDrug UtilizationFemaleFollow-Up StudiesHeart FailureHospitalizationHumansIowaMaleMedicaidMultivariate AnalysisMyocardial InfarctionPatient DischargeRetrospective StudiesStroke VolumeTachycardia, VentricularUnited StatesVentricular Function, LeftWisconsinConceptsAcute myocardial infarctionACE inhibitorsMyocardial infarctionDischarge medicationsVentricular functionEnzyme inhibitorsLeft ventricular ejection fractionAngiotensin-converting enzyme inhibitorAngiotensin converting enzyme (ACE) inhibitorsVentricular Enlargement (SAVE) trialCongestive heart failureVentricular ejection fractionYears of ageEligible patientsPatient characteristicsAppropriate patientsDiabetes mellitusEjection fractionHeart failureLoop diureticsMultivariable analysisVentricular tachycardiaIdeal patientObservational studyPatients