2008
A Randomized, Prospective, Double-Blind, Placebo-Controlled Trial of Terlipressin for Type 1 Hepatorenal Syndrome
Sanyal AJ, Boyer T, Garcia–Tsao G, Regenstein F, Rossaro L, Appenrodt B, Blei A, Gülberg V, Sigal S, Teuber P, Group T. A Randomized, Prospective, Double-Blind, Placebo-Controlled Trial of Terlipressin for Type 1 Hepatorenal Syndrome. Gastroenterology 2008, 134: 1360-1368. PMID: 18471513, PMCID: PMC3730280, DOI: 10.1053/j.gastro.2008.02.014.Peer-Reviewed Original ResearchMeSH KeywordsDose-Response Relationship, DrugDouble-Blind MethodFemaleFollow-Up StudiesGermanyHepatorenal SyndromeHumansInjections, IntravenousKidney Function TestsLypressinMaleMiddle AgedProspective StudiesRussiaSeverity of Illness IndexShock, SepticSurvival RateTerlipressinTreatment OutcomeUnited StatesVasoconstrictor AgentsConceptsHRS type 1Type 1 HRSSCr levelsTreatment successDay 14Type 1Total adverse event rateType 1 hepatorenal syndromePlacebo-controlled clinical trialSafety of terlipressinTrial of terlipressinAdvanced liver diseaseFunctional renal failureNonfatal myocardial infarctionSerum creatinine levelsTransplantation-free survivalAdverse event ratesSyndrome type 1Arterial vasoconstrictorHepatorenal syndromeHRS reversalCreatinine levelsRenal failureRenal functionLiver disease
1999
Bacterial translocation in cirrhotic rats stimulates eNOS-derived NO production and impairs mesenteric vascular contractility
Wiest R, Das S, Cadelina G, Garcia-Tsao G, Milstien S, Groszmann R. Bacterial translocation in cirrhotic rats stimulates eNOS-derived NO production and impairs mesenteric vascular contractility. Journal Of Clinical Investigation 1999, 104: 1223-1233. PMID: 10545521, PMCID: PMC409820, DOI: 10.1172/jci7458.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBacterial TranslocationDose-Response Relationship, DrugLiver Cirrhosis, ExperimentalLymph NodesMaleMesenteric ArteriesMethoxamineNitric OxideNitric Oxide SynthasePerfusionPressureProtein IsoformsRatsRats, Sprague-DawleyStress, MechanicalTumor Necrosis Factor-alphaVasoconstrictionVasoconstrictor AgentsConceptsMesenteric lymph nodesEndothelial NO synthaseTNF-alpha productionAscitic cirrhotic ratsBacterial translocationCirrhotic ratsMesenteric vasculatureNitric oxidePresence of BTSuperior mesenteric arterial bedMesenteric arterial bedNitro-L-arginineTNF-alpha synthesisVascular hyporesponsivenessArterial vasodilationLiver cirrhosisLymph nodesVascular contractilityVascular responsesTNF-alphaArterial bedNO inhibitorNOS activityNO overproductionNO synthaseLow‐dose midazolam sedation: An option for patients undergoing serial hepatic venous pressure measurements
Steinlauf A, Garcia‐Tsao G, Zakko M, Dickey K, Gupta T, Groszmann R. Low‐dose midazolam sedation: An option for patients undergoing serial hepatic venous pressure measurements. Hepatology 1999, 29: 1070-1073. PMID: 10094948, DOI: 10.1002/hep.510290421.Peer-Reviewed Original ResearchConceptsHepatic venous pressure gradientHepatic venous pressure measurementsWedged hepatic venous pressureFree hepatic venous pressureVenous pressure measurementsHepatic venous pressurePortal hypertensionVenous pressureSerial measurementsPatient comfortVenous pressure gradientDoses of midazolamDouble-blind studyDose of midazolamHigh-dose midazolamEffects of midazolamEffects of sedativesPortal pressure measurementsPressure measurementsCompensated cirrhosisVariceal hemorrhageCirrhotic patientsPharmacological therapyMidazolam sedationPrognostic index
1983
A study with quinfamide in the treatment of chronic amebiasis in adults.
Guevara L, Garcia Tsao G, Uscanga L. A study with quinfamide in the treatment of chronic amebiasis in adults. Clinical Therapeutics 1983, 6: 43-6. PMID: 6673830.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAmebiasisAmebicidesChronic DiseaseDose-Response Relationship, DrugDrug Administration ScheduleFemaleHumansMaleMiddle AgedQuinolines