2010
Sildenafil Has No Effect on Portal Pressure but Lowers Arterial Pressure in Patients With Compensated Cirrhosis
Tandon P, Inayat I, Tal M, Spector M, Shea M, Groszmann RJ, Garcia–Tsao G. Sildenafil Has No Effect on Portal Pressure but Lowers Arterial Pressure in Patients With Compensated Cirrhosis. Clinical Gastroenterology And Hepatology 2010, 8: 546-549. PMID: 20144739, PMCID: PMC2879450, DOI: 10.1016/j.cgh.2010.01.017.Peer-Reviewed Original ResearchConceptsHepatic venous pressure gradientMean arterial pressurePortal pressureArterial pressureHeart rateBaseline hepatic venous pressure gradientMedian mean arterial pressureOpen-label pilot studyPhosphodiesterase-5 inhibitor sildenafilSystemic vasodilatory effectVenous pressure gradientEffect of sildenafilPortal venous inflowIntrahepatic resistanceOral sildenafilCompensated cirrhosisCirrhotic patientsVasodilatory effectChild APortal hemodynamicsErectile dysfunctionVenous inflowInhibitor sildenafilTherapeutic dosesPatients
2003
Bacterial translocation up‐regulates GTP‐cyclohydrolase I in mesenteric vasculature of cirrhotic rats
Wiest R, Cadelina G, Milstien S, McCuskey RS, Garcia‐Tsao G, Groszmann RJ. Bacterial translocation up‐regulates GTP‐cyclohydrolase I in mesenteric vasculature of cirrhotic rats. Hepatology 2003, 38: 1508-1515. PMID: 14647062, DOI: 10.1016/j.hep.2003.09.039.Peer-Reviewed Original ResearchConceptsBacterial translocationMesenteric lymph nodesMesenteric vasculatureGTPCH I activitySerum endotoxinCirrhotic ratsNitric oxideSerum NOx levelsVascular NO productionStandard bacteriologic cultureEssential cofactor tetrahydrobiopterinLimulus amebocyte lysate assayArterial vasodilationArterial pressureLymph nodesHemodynamic disturbancesMesenteric circulationSystemic appearanceEndotoxemiaNO productionBacteriologic cultureNOx levelsCofactor tetrahydrobiopterinEndotoxinLysate assay
1991
Propranolol in the prevention of the first hemorrhage from esophagogastric varices: A multicenter, randomized clinical trial
Conn H, Grace N, Bosch J, Groszmann R, Rodés J, Wright S, Matloff D, Garcia‐Tsao G, Fisher R, Navasa M, Drewniak S, Atterbury C, Bordas J, Lerner E, Bramante C. Propranolol in the prevention of the first hemorrhage from esophagogastric varices: A multicenter, randomized clinical trial. Hepatology 1991, 13: 902-912. PMID: 2029994, DOI: 10.1002/hep.1840130517.Peer-Reviewed Original ResearchConceptsHepatic venous pressure gradientVenous pressure gradientPlacebo groupPropranolol groupEsophageal varicesVariceal hemorrhageChild class AEffectiveness of propranololFirst variceal hemorrhageInitial variceal hemorrhageCessation of therapyPortal hypertensive gastropathyChild class BDoses of propranololLarge esophageal varicesHepatic vein cathetersBeats/minClass BPlacebo patientsPropranolol patientsAlcoholic cirrhosisHypertensive gastropathyMean followMedian doseLarge varices
1990
Hemodynamic events in a prospective randomized trial of propranolol versus placebo in the prevention of a first variceal hemorrhage
Groszmann R, Bosch J, Grace N, Conn H, Garcia-Tsao G, Navasa M, Alberts J, Rodes J, Fischer R, Bermann M, Rofe S, Patrick M, Lerner E. Hemodynamic events in a prospective randomized trial of propranolol versus placebo in the prevention of a first variceal hemorrhage. Gastroenterology 1990, 99: 1401-1407. PMID: 2210246, DOI: 10.1016/0016-5085(90)91168-6.Peer-Reviewed Original ResearchConceptsHepatic venous pressure gradientVenous pressure gradientVariceal hemorrhageEsophageal varicesHemodynamic eventsBaseline valuesHeart rateFirst variceal hemorrhagePropranolol-treated groupPropranolol-treated patientsTrial of propranololAdministration of propranololBeginning of therapyRate of survivalPortal hypertensionVariceal bleedingCirrhotic patientsPharmacological therapyVariceal sizeProtective effectMortality ratePatientsPlaceboPropranololVarices
1989
Association of transdermal nitroglycerin to vasopressin infusion in the treatment of variceal hemorrhage: A placebo‐controlled clinical trial
Bosch J, Groszmann R, García‐Pagán J, Terés J, García‐Tsao G, Navasa M, Mas A, Rodés J. Association of transdermal nitroglycerin to vasopressin infusion in the treatment of variceal hemorrhage: A placebo‐controlled clinical trial. Hepatology 1989, 10: 962-968. PMID: 2511136, DOI: 10.1002/hep.1840100612.Peer-Reviewed Original ResearchConceptsTransdermal nitroglycerinVariceal hemorrhageVariceal bleedingPlacebo-controlled clinical trialActive variceal bleedingEffectiveness of vasopressinDouble-blind techniqueSlow-release preparationHospital mortalityTransfusion requirementsRecurrent bleedingBalloon tamponadeCirrhotic patientsEmergency surgeryVasopressin infusionClinical trialsDefinitive controlDrug combinationsTotal doseNitroglycerinBleedingHemorrhagePatientsInitial controlVasopressin
1987
Hemodynamic evaluation of isosorbide dinitrate in alcoholic cirrhosis Pharmacokinetic-hemodynamic interactions
Blei A, Garcia-Tsao G, Groszmann R, Kahrilas P, Ganger D, Morse S, Fung H. Hemodynamic evaluation of isosorbide dinitrate in alcoholic cirrhosis Pharmacokinetic-hemodynamic interactions. Gastroenterology 1987, 93: 576-583. PMID: 3301517, DOI: 10.1016/0016-5085(87)90921-8.Peer-Reviewed Original ResearchConceptsIsosorbide dinitratePortal pressureArterial pressureHemodynamic changesHemodynamic evaluationHepatic vein wedge pressureHepatic venous gradientSystemic hemodynamic changesMean arterial pressureEffects of placeboValues 4 hStable cirrhoticsAlcoholic cirrhosisCardiac indexPortal hypertensionWedge pressureHemodynamic benefitsVenous gradientVasoactive metabolitesPharmacologic agentsIndividual patientsBaseline valuesExperimental animalsDinitratePatientsPortal hemodynamics during nitroglycerin administration in cirrhotic patients
Garcia‐Tsao G, Groszmann R. Portal hemodynamics during nitroglycerin administration in cirrhotic patients. Hepatology 1987, 7: 805-809. PMID: 3115881, DOI: 10.1002/hep.1840070502.Peer-Reviewed Original ResearchConceptsHepatic venous pressure gradientVenous pressure gradientEffects of nitroglycerinMean arterial pressurePortal pressureArterial pressureNitroglycerin administrationBlood flowExperimental animalsAzygos blood flowPortal venous hemodynamicsPortal hypertensive patientsPortal blood flowVenous dilatorHypertensive patientsAlcoholic cirrhosisArterial vasodilatorCirrhotic patientsBlood pressurePortal hemodynamicsSublingual nitroglycerinVenous hemodynamicsHemodynamic responsePeak changesHeart rate