Colchicine in the Treatment of Cirrhosis of the Liver
Kershenobich D, Vargas F, Garcia-Tsao G, Tamayo R, Gent M, Rojkind M. Colchicine in the Treatment of Cirrhosis of the Liver. New England Journal Of Medicine 1988, 318: 1709-1713. PMID: 3287167, DOI: 10.1056/nejm198806303182602.Peer-Reviewed Original ResearchConceptsTreatment of cirrhosisPlacebo groupHistologic improvementColchicine groupSurvival rateMinimal portal fibrosisPlacebo-controlled trialPercent of patientsUse of colchicineAlcoholic cirrhosisOverall survivalPortal fibrosisMore biopsiesHepatic cirrhosisLiver biopsyPosthepatitic cirrhosisHistologic studyC. FiftyCirrhosisSide effectsPatientsCollagen synthesisLiverBiopsyPreliminary evidence