2003
Bacterial translocation up‐regulates GTP‐cyclohydrolase I in mesenteric vasculature of cirrhotic rats
Wiest R, Cadelina G, Milstien S, McCuskey RS, Garcia‐Tsao G, Groszmann RJ. Bacterial translocation up‐regulates GTP‐cyclohydrolase I in mesenteric vasculature of cirrhotic rats. Hepatology 2003, 38: 1508-1515. PMID: 14647062, DOI: 10.1016/j.hep.2003.09.039.Peer-Reviewed Original ResearchConceptsBacterial translocationMesenteric lymph nodesMesenteric vasculatureGTPCH I activitySerum endotoxinCirrhotic ratsNitric oxideSerum NOx levelsVascular NO productionStandard bacteriologic cultureEssential cofactor tetrahydrobiopterinLimulus amebocyte lysate assayArterial vasodilationArterial pressureLymph nodesHemodynamic disturbancesMesenteric circulationSystemic appearanceEndotoxemiaNO productionBacteriologic cultureNOx levelsCofactor tetrahydrobiopterinEndotoxinLysate assay
1999
Bacterial translocation in cirrhotic rats stimulates eNOS-derived NO production and impairs mesenteric vascular contractility
Wiest R, Das S, Cadelina G, Garcia-Tsao G, Milstien S, Groszmann R. Bacterial translocation in cirrhotic rats stimulates eNOS-derived NO production and impairs mesenteric vascular contractility. Journal Of Clinical Investigation 1999, 104: 1223-1233. PMID: 10545521, PMCID: PMC409820, DOI: 10.1172/jci7458.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBacterial TranslocationDose-Response Relationship, DrugLiver Cirrhosis, ExperimentalLymph NodesMaleMesenteric ArteriesMethoxamineNitric OxideNitric Oxide SynthasePerfusionPressureProtein IsoformsRatsRats, Sprague-DawleyStress, MechanicalTumor Necrosis Factor-alphaVasoconstrictionVasoconstrictor AgentsConceptsMesenteric lymph nodesEndothelial NO synthaseTNF-alpha productionAscitic cirrhotic ratsBacterial translocationCirrhotic ratsMesenteric vasculatureNitric oxidePresence of BTSuperior mesenteric arterial bedMesenteric arterial bedNitro-L-arginineTNF-alpha synthesisVascular hyporesponsivenessArterial vasodilationLiver cirrhosisLymph nodesVascular contractilityVascular responsesTNF-alphaArterial bedNO inhibitorNOS activityNO overproductionNO synthase