2010
Sildenafil Has No Effect on Portal Pressure but Lowers Arterial Pressure in Patients With Compensated Cirrhosis
Tandon P, Inayat I, Tal M, Spector M, Shea M, Groszmann RJ, Garcia–Tsao G. Sildenafil Has No Effect on Portal Pressure but Lowers Arterial Pressure in Patients With Compensated Cirrhosis. Clinical Gastroenterology And Hepatology 2010, 8: 546-549. PMID: 20144739, PMCID: PMC2879450, DOI: 10.1016/j.cgh.2010.01.017.Peer-Reviewed Original ResearchConceptsHepatic venous pressure gradientMean arterial pressurePortal pressureArterial pressureHeart rateBaseline hepatic venous pressure gradientMedian mean arterial pressureOpen-label pilot studyPhosphodiesterase-5 inhibitor sildenafilSystemic vasodilatory effectVenous pressure gradientEffect of sildenafilPortal venous inflowIntrahepatic resistanceOral sildenafilCompensated cirrhosisCirrhotic patientsVasodilatory effectChild APortal hemodynamicsErectile dysfunctionVenous inflowInhibitor sildenafilTherapeutic dosesPatients
2003
Portal hypertension
GarciaTsao G. Portal hypertension. Current Opinion In Internal Medicine 2003, 2: 229-237. DOI: 10.1097/00132980-200302030-00003.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsPortal hypertensionHyperdynamic circulationPortosystemic encephalopathyAccumulation of neurotoxinsPortal venous inflowSpontaneous bacterial peritonitisEffective blood volumeExtreme vasodilatationHepatorenal syndromeRenal vasoconstrictionSinusoidal hypertensionVasoconstrictive systemsGastroesophageal varicesIntrahepatic resistanceVariceal hemorrhageHemodynamic abnormalitiesRenal failureBacterial peritonitisCommon complicationHepatic insufficiencySodium retentionVenous inflowMain complicationsNeurohumoral systemsLethal infection
2001
Portal hypertension
Garcia-Tsao G. Portal hypertension. Current Opinion In Gastroenterology 2001, 17: 281-290. PMID: 17031170, DOI: 10.1097/00001574-200105000-00012.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsPortal hypertensionHyperdynamic circulationPortosystemic encephalopathyAccumulation of neurotoxinsSpontaneous bacterial peritonitisPortal venous inflowEffective blood volumeExtreme vasodilatationHepatorenal syndromeRenal vasoconstrictionSinusoidal hypertensionSplanchnic vasodilatationVasoconstrictive systemsGastroesophageal varicesIntrahepatic resistanceVariceal hemorrhageHemodynamic abnormalitiesRenal failureBacterial peritonitisCommon complicationHepatic insufficiencySodium retentionVenous inflowMain complicationsNeurohumoral systems