1986
Dietary fish oil reduces progression of established renal disease in (NZB × NZW)F1 mice and delays renal disease in BXSB and MRL/1 strains
Robinson D, Prickett J, Makoul G, Steinberg A, Colvin R. Dietary fish oil reduces progression of established renal disease in (NZB × NZW)F1 mice and delays renal disease in BXSB and MRL/1 strains. Arthritis & Rheumatism 1986, 29: 539-546. PMID: 3707632, DOI: 10.1002/art.1780290412.Peer-Reviewed Original ResearchConceptsMRL-lpr/lpr miceRenal diseaseLpr miceNew Zealand black x New ZealandMedium-sized renal arteriesMice fed menhaden oilMenhaden oilDietary marine lipidsOvert renal diseaseSeverity of glomerulonephritisDietary fish oilBXSB/MpJRate of mortalityNecrotizing vasculitisHistologic severityGlomerular injuryNZB ×Renal arteryFatty acidsHistologic evidenceControl animalsMO dietLipid dietDiseaseMice
1985
Effects of timed melatonin injections on reproduction in pinealectomized Peromyscus leucopus
Hall E, Makoul G, Lynch G, Anderson G. Effects of timed melatonin injections on reproduction in pinealectomized Peromyscus leucopus. General And Comparative Endocrinology 1985, 58: 407-414. PMID: 4007479, DOI: 10.1016/0016-6480(85)90113-3.Peer-Reviewed Original ResearchConceptsSham-operated miceReproductive tract weightMelatonin injectionsMicrograms melatoninSham-operated animalsSurgical treatmentDaily injectionsPinealectomized miceSurgeryClearance rateMelatonin concentrationsMicePlasma melatoninTime pointsWeeksMelatoninInjectionWhite-footed miceHigh-performance liquid chromatographyHrPinealectomizedLong-day photoperiodLiquid chromatographyGroupRadioimmunoassayProstaglandin E2 inhibits the activation of cloned T cell hybridomas.
Makoul G, Robinson D, Bhalla A, Glimcher L. Prostaglandin E2 inhibits the activation of cloned T cell hybridomas. The Journal Of Immunology 1985, 134: 2645-50. PMID: 2857750, DOI: 10.4049/jimmunol.134.4.2645.Peer-Reviewed Original ResearchConceptsIL-2 secretionT cell hybridomasProstaglandin E2T cellsStimulator cellsCell hybridomasTA3 cellsCAMP levelsMarked inhibitionConcentrations of PGE2M prostaglandin E2IL-2 productionT cell activationDose-dependent mannerT hybridoma cellsMitogenic signalsImmunosuppressive effectsInterleukin-2M. PretreatmentSignificant elevationCell activationPhysiologic concentrationsMin of additionSimilar pretreatmentDcAMP