Prostaglandin E2 inhibits the activation of cloned T cell hybridomas.
Makoul G, Robinson D, Bhalla A, Glimcher L. Prostaglandin E2 inhibits the activation of cloned T cell hybridomas. The Journal Of Immunology 1985, 134: 2645-50. PMID: 2857750, DOI: 10.4049/jimmunol.134.4.2645.Peer-Reviewed Original ResearchConceptsIL-2 secretionT cell hybridomasProstaglandin E2T cellsStimulator cellsCell hybridomasTA3 cellsCAMP levelsMarked inhibitionConcentrations of PGE2M prostaglandin E2IL-2 productionT cell activationDose-dependent mannerT hybridoma cellsMitogenic signalsImmunosuppressive effectsInterleukin-2M. PretreatmentSignificant elevationCell activationPhysiologic concentrationsMin of additionSimilar pretreatmentDcAMP