2019
PPM1D mutations silence NAPRT gene expression and confer NAMPT inhibitor sensitivity in glioma
Fons NR, Sundaram RK, Breuer GA, Peng S, McLean RL, Kalathil AN, Schmidt MS, Carvalho DM, Mackay A, Jones C, Carcaboso ÁM, Nazarian J, Berens ME, Brenner C, Bindra RS. PPM1D mutations silence NAPRT gene expression and confer NAMPT inhibitor sensitivity in glioma. Nature Communications 2019, 10: 3790. PMID: 31439867, PMCID: PMC6706443, DOI: 10.1038/s41467-019-11732-6.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntineoplastic AgentsBrain Stem NeoplasmsCell Line, TumorChildCytokinesDiffuse Intrinsic Pontine GliomaDNA MethylationEpigenetic RepressionFemaleGene Expression Regulation, NeoplasticHumansMiceNicotinamide PhosphoribosyltransferasePonsPrimary Cell CultureProtein Phosphatase 2CSynthetic Lethal MutationsXenograft Model Antitumor AssaysConceptsNicotinic acid phosphoribosyltransferaseSynthetic lethal interactionsNAMPT inhibitorsTumor-specific cell killingProtein phosphataseEpigenetic silencingMutant cellsKey genesCpG islandsLethal interactionsNAD biosynthesisGene expressionInhibitor sensitivityNAD metabolismOncogenic rolePediatric gliomasMutationsModel systemCell killingDriver mutationsPediatric high-grade gliomasMutant tumorsOncogenic driver mutationsNicotinamide phosphoribosyltransferase (NAMPT) inhibitionGenome
2011
Caffeine Acts via A1 Adenosine Receptors to Disrupt Embryonic Cardiac Function
Buscariollo DL, Breuer GA, Wendler CC, Rivkees SA. Caffeine Acts via A1 Adenosine Receptors to Disrupt Embryonic Cardiac Function. PLOS ONE 2011, 6: e28296. PMID: 22164264, PMCID: PMC3229565, DOI: 10.1371/journal.pone.0028296.Peer-Reviewed Original ResearchConceptsReceptor-selective antagonistHeart rateA1 adenosine receptorsCardiac functionAdenosine receptorsRoom airNormal cardiac responseElevated heart rateEmbryonic cardiac functionEffects of caffeineCardiac A1 adenosine receptorsAdenosine actionA1AR expressionEmbryonic hypoxiaSCH 58261Isolated heartCaffeine exposureA1AR activationCardiac responseHeart functionCaffeine altersA2aAR geneA1AR actionHypoxiaReal-time PCR analysis