2011
HLA‐DR polymorphism modulates response to house dust mites in a transgenic mouse model of airway inflammation
Rajagopalan G, Tilahun A, Iijima K, David C, Kita H, Juhn Y. HLA‐DR polymorphism modulates response to house dust mites in a transgenic mouse model of airway inflammation. HLA 2011, 77: 589-592. PMID: 21447115, DOI: 10.1111/j.1399-0039.2010.01617.x.Peer-Reviewed Original ResearchConceptsHLA-DR3 transgenic miceHouse dust miteDust miteTransgenic miceTh2-predominant immune responseHouse dust mite extractInterleukin-13 levelsInflammatory cell countsBronchoalveolar lavage fluidTh2-type inflammationTransgenic mouse modelHLA-DR polymorphismAirway inflammationCytokine levelsBAL fluidEosinophil countHLA-DR3Childhood asthmaHLA-DR2Lavage fluidMite extractHLA-DRB1Immune responseInterleukin-4Mouse model
2006
IL-10-deficiency unmasks unique immune system defects and reveals differential regulation of organ-specific autoimmunity in non-obese diabetic mice
Rajagopalan G, Kudva Y, Sen M, Marietta E, Murali N, Nath K, Moore J, David C. IL-10-deficiency unmasks unique immune system defects and reveals differential regulation of organ-specific autoimmunity in non-obese diabetic mice. Cytokine 2006, 34: 85-95. PMID: 16740391, DOI: 10.1016/j.cyto.2006.04.006.Peer-Reviewed Original ResearchConceptsOrgan-specific autoimmunityComplete Freund's adjuvantNOD miceRectal prolapseToll-like receptor 9 agonistSystemic inflammatory cytokine responsesTh1-type autoimmune diseaseNon-obese diabetic (NOD) micePotent anti-inflammatory cytokineCyclophosphamide-induced diabetesDiabetic NOD miceIL-10 deficiencyAnti-inflammatory cytokinesReceptor 9 agonistInflammatory cytokine responseImmune system defectsType 1 diabetesPathogen-free conditionsSplenic macrophage numbersAdoptive transferIL-10Cytokine responsesDiabetic miceFreund's adjuvantAutoimmune diseases