2012
Chronic Exposure to Staphylococcal Superantigen Elicits a Systemic Inflammatory Disease Mimicking Lupus
Chowdhary VR, Tilahun AY, Clark CR, Grande JP, Rajagopalan G. Chronic Exposure to Staphylococcal Superantigen Elicits a Systemic Inflammatory Disease Mimicking Lupus. The Journal Of Immunology 2012, 189: 2054-2062. PMID: 22798666, PMCID: PMC3462343, DOI: 10.4049/jimmunol.1201097.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAutoantibodiesAutoantigensAutoimmune DiseasesCD28 AntigensCD4-Positive T-LymphocytesEnzyme-Linked Immunosorbent AssayFlow CytometryFluorescent Antibody TechniqueHLA-DQ AntigensHumansInfusions, SubcutaneousLupus Erythematosus, SystemicMiceMice, TransgenicStaphylococcus aureusSuperantigensConceptsSystemic lupus erythematosusT cellsChronic exposureStaphylococcal enterotoxin BLupus erythematosusMouse MHC class II moleculesHLA-DQ8 transgenic miceMultisystem autoimmune inflammatory diseaseEnterotoxin BHLA-DQ8 miceAutoimmune inflammatory diseaseMHC class II moleculesTh1-type cytokinesMini-osmotic pumpsMononuclear cell infiltrationAnti-nuclear AbsClass II moleculesAbsence of diseaseChronic nasalIL-12Inflammatory infiltrateAutoimmune diseasesCell infiltrationInflammatory diseasesPathogenic role
2007
Autoimmunity in HLA-DQ8 transgenic mice expressing granulocyte/macrophage-colony stimulating factor in the beta cells of islets of langerhans
Rajagopalan G, Mangalam A, Sen M, Cheng S, Kudva Y, David C. Autoimmunity in HLA-DQ8 transgenic mice expressing granulocyte/macrophage-colony stimulating factor in the beta cells of islets of langerhans. Autoimmunity 2007, 40: 169-179. PMID: 17453715, DOI: 10.1080/08916930701201083.Peer-Reviewed Original ResearchConceptsHLA-DQ8GM-CSFDQ8 miceAutoimmune diabetesHLA-DQ8 transgenic miceMarked mononuclear cell infiltrationPotent immunostimulatory cytokineSpontaneous autoimmune diabetesMononuclear cell infiltrationNOD genetic backgroundGranulocyte/macrophage-colony stimulating factorStrong HLA associationType 1 diabetesPolygenic autoimmune diseasesMacrophage-colony stimulating factorLiver of miceMacrophage colony-stimulating factorGranulocyte/macrophage colony-stimulating factorColony-stimulating factorHLA associationsImmunostimulatory cytokinesAutoimmune diseasesCell infiltrationBeta cellsTransgenic mice