Understanding Interstitial Lung Diseases Associated with Connective Tissue Disease (CTD-ILD): Genetics, Cellular Pathophysiology, and Biologic Drivers
Chiang G, Parimon T. Understanding Interstitial Lung Diseases Associated with Connective Tissue Disease (CTD-ILD): Genetics, Cellular Pathophysiology, and Biologic Drivers. International Journal Of Molecular Sciences 2023, 24: 2405. PMID: 36768729, PMCID: PMC9917355, DOI: 10.3390/ijms24032405.Peer-Reviewed Original ResearchConceptsConnective tissue disease-associated interstitial lung diseaseInterstitial lung diseaseLung diseaseRisk factorsLung fibrosisSystemic autoimmune disorderConnective tissue diseaseFibrotic lung diseaseIdiopathic pulmonary fibrosisCommon risk factorsPre-clinical modelsLung fibroblast proliferationEnvironmental risk factorsPrimary pathogenic mechanismDisease biomarkersInflammatory cascadePulmonary fibrosisTissue diseaseAutoimmune disordersProfibrotic pathwaysDisease prognosticationPathogenetic mechanismsTargeted therapyCell dysfunctionEarly diagnosis