2014
Intensified specimen collection to improve tuberculosis diagnosis in children from Rural South Africa, an observational study
Thomas TA, Heysell SK, Moodley P, Montreuil R, Ha X, Friedland G, Bamber SA, Moll AP, Gandhi N, Brant WE, Sturm W, Shah S. Intensified specimen collection to improve tuberculosis diagnosis in children from Rural South Africa, an observational study. BMC Infectious Diseases 2014, 14: 11. PMID: 24400822, PMCID: PMC3890632, DOI: 10.1186/1471-2334-14-11.Peer-Reviewed Original ResearchConceptsDrug susceptibility testingGastric aspiratesTB suspectsObservational studySpecimen collectionDrug-susceptible TBNew TB suspectsPediatric TB suspectsTB treatment historyXDR-TB casesMultiple specimen typesYears of ageSame-day methodTB settingsInduced sputumPersistent symptomsSputum inductionTB treatmentHIV statusNegative childrenTB diagnosisUrine cultureMean ageInpatient settingDiagnostic yield
2010
Blood cultures for the diagnosis of multidrug-resistant and extensively drug-resistant tuberculosis among HIV-infected patients from rural South Africa: a cross-sectional study
Heysell SK, Thomas TA, Gandhi NR, Moll AP, Eksteen FJ, Coovadia Y, Roux L, Babaria P, Lalloo U, Friedland G, Shah S. Blood cultures for the diagnosis of multidrug-resistant and extensively drug-resistant tuberculosis among HIV-infected patients from rural South Africa: a cross-sectional study. BMC Infectious Diseases 2010, 10: 344. PMID: 21134279, PMCID: PMC3016377, DOI: 10.1186/1471-2334-10-344.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAIDS-Related Opportunistic InfectionsChildChild, PreschoolCross-Sectional StudiesExtensively Drug-Resistant TuberculosisFemaleHIV InfectionsHumansInfantInfant, NewbornMaleMiddle AgedMycobacterium tuberculosisRetrospective StudiesRisk FactorsRural PopulationSouth AfricaSputumYoung AdultConceptsDrug-resistant TBMycobacterial blood culturesDrug-resistant tuberculosisBlood culturesXDR-TBRural South AfricaMDR-TBM. tuberculosisMycobacterium tuberculosis bacteremiaCross-sectional studyPositive blood culturesDiagnosis of MDRCross-sectional analysisAntiretroviral therapySecondary outcomesSputum cultureTB suspectsRisk factorsPatientsHIVTuberculosisDiagnosisTBSimilar settingsBacteremiaOpportunities afforded by new drugs for tuberculosis
Churchyard GJ, Friedland G, Fielding K, Nardell E. Opportunities afforded by new drugs for tuberculosis. The Lancet Infectious Diseases 2010, 10: 368-369. PMID: 20510274, DOI: 10.1016/s1473-3099(10)70095-5.Peer-Reviewed Original Research
1996
Invasive Pneumococcal Disease: Clinical Features, Serotypes, and Antimicrobial Resistance Patterns in Cases Involving Patients with and Without Human Immunodeficiency Virus Infection
Frankel R, Virata M, Hardalo C, Altice F, Friedland G. Invasive Pneumococcal Disease: Clinical Features, Serotypes, and Antimicrobial Resistance Patterns in Cases Involving Patients with and Without Human Immunodeficiency Virus Infection. Clinical Infectious Diseases 1996, 23: 577-584. PMID: 8879783, DOI: 10.1093/clinids/23.3.577.Peer-Reviewed Original ResearchConceptsInvasive pneumococcal diseasePneumococcal diseaseClinical featuresPenicillin-resistant pneumococcal infectionsHuman immunodeficiency virus (HIV) diseaseHuman immunodeficiency virus (HIV) infectionCommon capsular typesSource of bacteremiaImmunodeficiency virus infectionOverall mortality rateAntibiotic susceptibility patternPolyvalent pneumococcal vaccineType 9VCommon risk factorsPenicillin-resistant isolatesAntimicrobial resistance patternsPneumococcal infectionPneumococcal vaccineHIV infectionHIV serostatusHIV statusRecurrence rateInvasive diseaseRisk factorsSusceptibility patterns
1990
Additional evidence for lack of transmission of HIV infection by close interpersonal (casual) contact
Friedland G, Kahl P, Saltzman B, Rogers M, Feiner C, Mayers M, Schable C, Klein R. Additional evidence for lack of transmission of HIV infection by close interpersonal (casual) contact. AIDS 1990, 4: 639-644. PMID: 2118767, DOI: 10.1097/00002030-199007000-00005.Peer-Reviewed Original ResearchConceptsHousehold contactsHIV infectionAIDS patientsClose interpersonal contactNon-sexual contactsPossibility of transmissionAdult patientsHIV antibodiesMedian durationMedian timeP24 antigenHIV transmissionPhysical examinationSerum antibodiesPatientsLast contactLack of transmissionLast evaluationInitial evaluationMonthsInfectionHIVSymptomsAntigenAIDS