1998
Methadone Effects on Zidovudine Disposition (AIDS Clinical Trials Group 262)
McCanceKatz E, Rainey P, Jatlow P, Friedland G. Methadone Effects on Zidovudine Disposition (AIDS Clinical Trials Group 262). JAIDS Journal Of Acquired Immune Deficiency Syndromes 1998, 18: 435-443. PMID: 9715839, DOI: 10.1097/00042560-199808150-00004.Peer-Reviewed Original ResearchConceptsInjection drug usersMethadone treatmentChronic methadone treatmentMethadone-maintained patientsHeroin-addicted patientsMethadone effectsZDV doseZDV exposureZDV pharmacokineticsZDV treatmentZidovudine dispositionZidovudine therapyHIV diseaseMethadone levelsPharmacokinetic interactionsTherapeutic rangeRenal clearanceToxicity surveillanceSide effectsDrug usersDrug efficacyZDVClearanceAUCPatients
1992
Pharmacokinetic interactions of zidovudine and methadone in intravenous drug-using patients with HIV infection.
Schwartz E, Brechbühl A, Kahl P, Miller M, Selwyn P, Friedland G. Pharmacokinetic interactions of zidovudine and methadone in intravenous drug-using patients with HIV infection. JAIDS Journal Of Acquired Immune Deficiency Syndromes 1992, 5: 619-26. PMID: 1588496.Peer-Reviewed Original ResearchConceptsIntravenous drug usersControl patientsMethadone patientsPharmacokinetic parametersHigh-pressure liquid chromatographyFormer intravenous drug usersIntravenous drug-using patientsMethadone maintenance therapyDrug-using patientsConcentration-time curveHuman hepatic microsomesZDV levelsZDV therapyZDV treatmentMaintenance therapyMethadone concentrationsMethadone groupHIV infectionPharmacokinetic interactionsSerum levelsConcurrent administrationIVDU patientsUrinary excretionPatientsZidovudine