The chitinase and chitinase-like proteins: a review of genetic and functional studies in asthma and immune-mediated diseases
Ober C, Chupp GL. The chitinase and chitinase-like proteins: a review of genetic and functional studies in asthma and immune-mediated diseases. Current Opinion In Allergy And Clinical Immunology 2009, 9: 401-408. PMID: 19644363, PMCID: PMC3018778, DOI: 10.1097/aci.0b013e3283306533.Peer-Reviewed Original ResearchConceptsChitinase-like proteinsNovel asthma susceptibility genesAsthma susceptibility genesRegulatory SNPsNonsynonymous SNPsNonfunctional allelesDiverse ancestryGenetic studiesChitinase activityGenesSusceptibility genesFunctional studiesChitinaseDuplication alleleMammalian chitinaseProteinMajor chitinaseEnzyme activityPolymorphismSNPsChiaAllelesCHIT1CHI3L1Present review