2009
The chitinase and chitinase-like proteins: a review of genetic and functional studies in asthma and immune-mediated diseases
Ober C, Chupp GL. The chitinase and chitinase-like proteins: a review of genetic and functional studies in asthma and immune-mediated diseases. Current Opinion In Allergy And Clinical Immunology 2009, 9: 401-408. PMID: 19644363, PMCID: PMC3018778, DOI: 10.1097/aci.0b013e3283306533.Peer-Reviewed Original ResearchConceptsChitinase-like proteinsNovel asthma susceptibility genesAsthma susceptibility genesRegulatory SNPsNonsynonymous SNPsNonfunctional allelesDiverse ancestryGenetic studiesChitinase activityGenesSusceptibility genesFunctional studiesChitinaseDuplication alleleMammalian chitinaseProteinMajor chitinaseEnzyme activityPolymorphismSNPsChiaAllelesCHIT1CHI3L1Present review
1997
A chemoattractant cytokine associated with granulomas in tuberculosis and silicosis
Nau G, Guilfoile P, Chupp G, Berman J, Kim S, Kornfeld H, Young R. A chemoattractant cytokine associated with granulomas in tuberculosis and silicosis. Proceedings Of The National Academy Of Sciences Of The United States Of America 1997, 94: 6414-6419. PMID: 9177232, PMCID: PMC21064, DOI: 10.1073/pnas.94.12.6414.Peer-Reviewed Original ResearchMeSH KeywordsBronchopneumoniaCell LineChemokine CCL4Chemotactic FactorsCytokinesDNA PrimersFerritinsGene LibraryGranulomaHumansImmunohistochemistryMacrophage Inflammatory ProteinsMacrophagesMacrophages, AlveolarMycobacterium bovisMycobacterium tuberculosisOsteopontinPolymerase Chain ReactionSialoglycoproteinsSilicosisTranscription, GeneticTuberculosisConceptsHuman genome sequenceMacrophage cDNA libraryHost cell genesGranuloma formationOsteopontin gene expressionPrimary human alveolar macrophagesGenome sequenceMononuclear cell infiltrateMycobacterium tuberculosis infectionHost genesCDNA libraryCell genesGene expressionHuman alveolar macrophagesAssociation of osteopontinGenesExtracellular matrixPathologic responseCell infiltrateTuberculosis infectionGranulomatous pathologyChronic inflammationGranulomatous diseaseChemoattractant cytokinesMacrophage chemoattractant