1997
Cloning and localization of a double-pore K channel, KCNK1: exclusive expression in distal nephron segments
Orias M, Velázquez H, Tung F, Lee G, Desir G. Cloning and localization of a double-pore K channel, KCNK1: exclusive expression in distal nephron segments. American Journal Of Physiology 1997, 273: f663-f666. PMID: 9362344, DOI: 10.1152/ajprenal.1997.273.4.f663.Peer-Reviewed Original ResearchConceptsThick ascending limbAscending limbK channelsCortical thick ascending limbMedullary thick ascending limbDistal nephron segmentsReverse transcription-polymerase chain reactionDistal convoluted tubuleTranscription-polymerase chain reactionDistal tubulesConvoluted tubulesProximal tubulesNephron segmentsHigh expressionNephron segment localizationK homeostasisChain reactionHuman kidney cDNATubulesSegment localizationExclusive expressionKCNK1LimbPore regionKidney cDNA
1993
Identification of a novel K-channel gene (KC22) that is highly expressed in distal tubule of rabbit kidney
Desir GV, Velazquez H. Identification of a novel K-channel gene (KC22) that is highly expressed in distal tubule of rabbit kidney. American Journal Of Physiology 1993, 264: f128-f133. PMID: 7679255, DOI: 10.1152/ajprenal.1993.264.1.f128.Peer-Reviewed Original ResearchConceptsPolymerase chain reactionRabbit kidneyKidney cortexWhole kidney cortexShaker gene familyDistal tubule cellsVoltage-gated K channelsRenal tissueDistal tubulesTubule cellsRibonuclease protectionPrimary culturesKidneyChain reactionExpression levelsK channelsCortexTubulesPartial-length sequencesAbundant isoformIsoformsKidney cDNAK channel genes