2002
Etiology and weekly occurrence of alcohol-related seizures.
Rathlev N, Ulrich A, Shieh T, Callum M, Bernstein E, D'Onofrio G. Etiology and weekly occurrence of alcohol-related seizures. Academic Emergency Medicine 2002, 9: 824-8. PMID: 12153888, DOI: 10.1111/j.1553-2712.2002.tb02171.x.Peer-Reviewed Original ResearchConceptsAlcohol-related seizuresAlcohol withdrawal seizuresAlcohol withdrawalIdentifiable causeWithdrawal seizuresGreater frequencyRetrospective chart reviewWeeks of presentationAlcohol-dependent patientsChart reviewConsecutive patientsSix-month periodIndividual patientsPatientsSeizuresPast historyWithdrawalWeekly occurrenceCauseDecreased availabilityMondayEtiologyPeriodPrevalenceWeeks
2000
Clinical Characteristics as Predictors of Recurrent Alcohol‐related Seizures
Rathlev N, Ulrich A, Fish S, D'Onofrio G. Clinical Characteristics as Predictors of Recurrent Alcohol‐related Seizures. Academic Emergency Medicine 2000, 7: 886-891. PMID: 10958128, DOI: 10.1111/j.1553-2712.2000.tb02066.x.Peer-Reviewed Original ResearchConceptsAlcohol-related seizuresClinical characteristicsBlood pressureEthanol levelsRecurrent seizuresLower riskLower-risk clinical characteristicsPlacebo-treated patientsDiastolic blood pressureSubset of patientsSystolic blood pressureRetrospective secondary analysisDaily ethanol consumptionRecurrent alcoholPlacebo armRandomized trialsPrevious seizuresEmergency departmentEthanol abuseClinical dataDrug treatmentHeart rateEthanol consumptionSeizuresRespiratory rate
1999
Lorazepam for the Prevention of Recurrent Seizures Related to Alcohol
D'Onofrio G, Rathlev N, Ulrich A, Fish S, Freedland E. Lorazepam for the Prevention of Recurrent Seizures Related to Alcohol. New England Journal Of Medicine 1999, 340: 915-919. PMID: 10094637, DOI: 10.1056/nejm199903253401203.Peer-Reviewed Original ResearchConceptsPlacebo groupRecurrent seizuresSecond seizureLorazepam groupEmergency departmentNormal salineAlcohol abusePrimary end pointDouble-blind studyChronic alcohol abuseYears of ageIntravenous lorazepamHospital dischargeConsecutive patientsGeneralized seizuresEntry criteriaCommon causePatientsSeizuresEnd pointLorazepamObservation periodSignificant reductionHospitalSaline
1994
The lack of efficacy of phenytoin in the prevention of recurrent alcohol-related seizures
Rathlev N, D'Onofrio G, Fish S, Harrison P, Bernstein E, Hossack R, Pickens L. The lack of efficacy of phenytoin in the prevention of recurrent alcohol-related seizures. Annals Of Emergency Medicine 1994, 23: 513-518. PMID: 8135426, DOI: 10.1016/s0196-0644(94)70070-2.Peer-Reviewed Original ResearchConceptsAlcohol-related seizuresSix-hour observation periodNormal saline placeboDouble-blind trialObservation periodConfidence intervalsLack of efficacyChronic alcohol abuseYears of ageChi 2 analysisPlacebo groupConsecutive adultsEligible subjectsPhenytoin groupSaline placeboGeneralized seizuresPhenytoin administrationSecond seizureEmergency departmentNormal salineRelative riskTeaching hospitalAlcohol abuseDrug AdministrationSeizures