2018
Chapter 39 Structure-Function Relationships in the Pancreatic Acinar Cell
Gorelick F, Pandol S, Jamieson J. Chapter 39 Structure-Function Relationships in the Pancreatic Acinar Cell. 2018, 869-894. DOI: 10.1016/b978-0-12-809954-4.00039-6.Peer-Reviewed Original ResearchProtein synthesisEnzyme precursorsRodent acinar cellsAcinar cellsZymogen granulesCritical physiologic functionsSecretion of enzymesStructure-function relationshipsMajor cell typesCellular functionsCell biologistsVesicular transportCell signalingGolgi complexHuman acinar cellsPhysiologic functionEndoplasmic reticulumDuct cellsCell organellesPancreatic acinar cellsCell typesEnzyme proteinDigestive enzymesEnzymeMajor physiologic function
2012
Chapter 49 Structure–function Relationships in the Pancreatic Acinar Cell
Gorelick F, Jamieson J. Chapter 49 Structure–function Relationships in the Pancreatic Acinar Cell. 2012, 1341-1360. DOI: 10.1016/b978-0-12-382026-6.00049-x.Peer-Reviewed Original ResearchProtein synthesisZymogen granulesAcinar cellsSecretion of enzymesStructure-function relationshipsNascent proteinsVesicular transportCell signalingEnzyme precursorsGolgi complexEndoplasmic reticulumPancreatic acinar cellsDigestive enzymesEnzymeModel systemExport protein synthesisVectorial mannerApical regionProteinCellsHormonal routesGranulesDigestionDietary proteinExocytosis
2005
Epidemiology and Pathophysiology of Acute Pancreatitis
Nagar A, Gorelick F. Epidemiology and Pathophysiology of Acute Pancreatitis. Clinical Gastroenterology 2005, 3-15. DOI: 10.1385/1-59259-815-3:003.Peer-Reviewed Original ResearchAcute pancreatitisNatural historyPathogenesis of APMultiorgan system failureRemote organ systemsAcute inflammatory processDegree of inflammationAcute attacksClinical courseCommon etiologyPancreatic inflammationSevere pancreatitisInflammatory processMild discomfortAlcohol abusePancreatitisRegional tissuesVariable involvementOrgan systemsComplete recoveryProapoptotic mediatorsPancreasInflammationIntracellular eventsZymogen granules
1998
Codistribution of TAP and the granule membrane protein GRAMP-92 in rat caerulein-induced pancreatitis
Otani T, Chepilko S, Grendell J, Gorelick F. Codistribution of TAP and the granule membrane protein GRAMP-92 in rat caerulein-induced pancreatitis. American Journal Of Physiology 1998, 275: g999-g1009. PMID: 9815030, DOI: 10.1152/ajpgi.1998.275.5.g999.Peer-Reviewed Original ResearchConceptsAcinar cell compartmentNumber of vesiclesRecycling endosomesSupranuclear compartmentPancreatic acinar cellsTime-dependent mannerProcessing siteCell compartmentTrypsinogen processingPhysiological levelsZymogen granulesImmunofluorescence studiesCaerulein-induced pancreatitisAcinar cellsActivation peptideTrypsinogen activation peptidePathological activationCompartmentsActivation
1997
Distribution of a Synthetic Protease Inhibitor in Rat Pancreatic Acini After Supramaximal Secretagogue Stimulation
Otani T, Atomi Y, Kuroda A, Muto T, Tamura M, Fukuda S, Akao S, Gorelick F. Distribution of a Synthetic Protease Inhibitor in Rat Pancreatic Acini After Supramaximal Secretagogue Stimulation. Pancreas 1997, 14: 142-149. PMID: 9057186, DOI: 10.1097/00006676-199703000-00006.Peer-Reviewed Original ResearchConceptsAcinar cellsPancreatic aciniProtease inhibitorsLow molecular weight protease inhibitorSynthetic protease inhibitorLarge cytoplasmic vacuolesIsolated pancreatic aciniRat pancreatic aciniAcute pancreatitisWeight protease inhibitorsZymogen granulesCerulein treatmentE3123Supramaximal secretagogue stimulationVivo modelElectron microscopic autoradiographyBeneficial effectsMin of incubationUnstimulated controlsMicroscopic autoradiographyInhibition of proteasesCytoplasmic vacuolesAciniPancreatitisFormation of vacuoles
1988
Development of Secretagogue Responsiveness in the Pancreas
Jamieson JD, Gorelick FS, Chang A. Development of Secretagogue Responsiveness in the Pancreas. Scandinavian Journal Of Gastroenterology 1988, 23: 98-103. PMID: 2852401, DOI: 10.3109/00365528809095920.Peer-Reviewed Original ResearchConceptsSecretory pathwaySecretory proteinsPancreatic acinar cellsEpithelial cell polarityDependent protein kinase IIRegulated secretory pathwayConstitutive secretory pathwayAcinar cellsProtein kinase IICell polarityMembrane proteinsPhosphorylated substratesRegulated secretionBasolateral domainCell biologyPlasmalemmal domainsPlasma membraneKinase IISecond messengerSecretagogue responsivenessFunctional specializationProteinEpithelial cellsPathwayZymogen granules