2024
Chemical complementarity of tumor resident, T-cell receptor CDR3s and renalase-1 correlates with increased melanoma survival
Zaman S, Gorelick F, Chrobrutskiy A, Chobrutskiy B, Desir G, Blanck G. Chemical complementarity of tumor resident, T-cell receptor CDR3s and renalase-1 correlates with increased melanoma survival. Oncotarget 2024, 15: 550-561. PMID: 39102218, PMCID: PMC11299663, DOI: 10.18632/oncotarget.28633.Peer-Reviewed Original ResearchConceptsT cell receptorOverall survivalT cellsAssociated with improved overall survivalT-cell receptor CDR3sPromote T cell activationImproved overall survivalSurvival of melanomaPancreatic cancer patientsT cell activationT cell receptor recognitionTumor-residentTumor rejectionMelanoma patientsMelanoma growthMelanoma survivalImmune signature genesSurvival associationsCancer patientsMelanomaSignature genesAmino acid sequenceSurvivalPatientsExpression levels
2023
Plasma renalase levels are associated with the development of acute pancreatitis
Wang M, Weiss F, Guo X, Kolodecik T, Bewersdorf J, Laine L, Lerch M, Desir G, Gorelick F. Plasma renalase levels are associated with the development of acute pancreatitis. Pancreatology 2023, 23: 158-162. PMID: 36697349, DOI: 10.1016/j.pan.2023.01.001.Peer-Reviewed Original ResearchConceptsAcute pancreatitisSevere diseasePlasma renalase levelsAcute pancreatitis patientsSevere acute pancreatitisAcute pancreatitis modelPlasma renalaseRenalase levelsSignificant morbidityPancreatitis patientsPlasma levelsHealthy controlsPancreatitis modelPancreatitisPatientsPlasma samplesRenalaseDiseaseNonparametric statistical analysisSecretory proteinsMorbidityStatistical analysisMortalityLevels
2019
Precision Medicine in Pancreatic Disease-Knowledge Gaps and Research Opportunities: Summary of a National Institute of Diabetes and Digestive and Kidney Diseases Workshop.
Lowe ME, Andersen DK, Caprioli RM, Choudhary J, Cruz-Monserrate Z, Dasyam AK, Forsmark CE, Gorelick FS, Gray JW, Haupt M, Kelly KA, Olive KP, Plevritis SK, Rappaport N, Roth HR, Steen H, Swamidass SJ, Tirkes T, Uc A, Veselkov K, Whitcomb DC, Habtezion A. Precision Medicine in Pancreatic Disease-Knowledge Gaps and Research Opportunities: Summary of a National Institute of Diabetes and Digestive and Kidney Diseases Workshop. Pancreas 2019, 48: 1250-1258. PMID: 31688587, PMCID: PMC7282491, DOI: 10.1097/mpa.0000000000001412.Peer-Reviewed Original ResearchConceptsPancreatic diseasePrecision medicineCurrent precision medicine approachesKidney Diseases workshopProspective clinical trialsNational InstitutePrecision medicine approachHealth care systemKidney diseaseRisk factorsClinical trialsFatal illnessMulticenter effortsMedicine approachDiseaseCare systemDisease mechanismsDiabetesPatient data setsMedicinePersonalized medicinePrecision imagingPatientsTherapyIllness
2013
Calcium Ameliorates Diarrhea in Immunocompromised Children
Cheng SX, Bai HX, Gonzalez‐Peralta R, Mistry PK, Gorelick FS. Calcium Ameliorates Diarrhea in Immunocompromised Children. Journal Of Pediatric Gastroenterology And Nutrition 2013, 56: 641-644. PMID: 23343935, PMCID: PMC4448079, DOI: 10.1097/mpg.0b013e3182868946.Peer-Reviewed Original Research
1997
Serologic Assay for Secretory Component Distinguishes Mechanical from Hepatocellular Cholestasis in Humans
Versland M, Wu G, Gorelick F, Larkin J. Serologic Assay for Secretory Component Distinguishes Mechanical from Hepatocellular Cholestasis in Humans. Digestive Diseases And Sciences 1997, 42: 2246-2253. PMID: 9398802, DOI: 10.1023/a:1018810500006.Peer-Reviewed Original ResearchAlcohol and Acute Pancreatitis
Robles-Diaz G, Gorelick F. Alcohol and Acute Pancreatitis. The Yale Journal Of Biology And Medicine 1997, 70: 77-87. PMCID: PMC2589130.Peer-Reviewed Original Research
1983
Duodenal epithelial thymidine uptake in patients with duodenal ulcer or endoscopic duodenitis
Gorelick F, Deluca V, Sheahan D, Marignani P, Goldblatt R, Winnan J, Livstone E. Duodenal epithelial thymidine uptake in patients with duodenal ulcer or endoscopic duodenitis. Digestive Diseases And Sciences 1983, 28: 392-396. PMID: 6839902, DOI: 10.1007/bf02430526.Peer-Reviewed Original ResearchConceptsEndoscopic duodenitisDuodenal ulcerControl subjectsDuodenal mucosaProliferative indexControl groupChronic active duodenitisDuodenal ulcer diseaseEpithelial cell renewalActive duodenitisChronic duodenitisDuodenal ulcerationMucosal biopsiesUlcer diseaseInflammatory processDuodenitisGastrointestinal tractHistologic appearanceEpithelial proliferationPatientsUlcersCrypt sizeThymidine uptakeMucosaCell renewal
1982
Somatostatin Decreases Diarrhea in Patients with the Short-Bowel Syndrome
Dharmsathaphorn K, Gorelick FS, Sherwin RS, Cataland S, Dobbins JW. Somatostatin Decreases Diarrhea in Patients with the Short-Bowel Syndrome. Journal Of Clinical Gastroenterology 1982, 4: 521-524. PMID: 6131090, DOI: 10.1097/00004836-198212000-00008.Peer-Reviewed Original ResearchConceptsShort bowel syndromeCrohn's diseaseStool weightMultiple small bowel resectionsPostprandial glucose levelsSmall bowel resectionAbstract Four patientsFour patientsRefractory diarrheaSomatostatin infusionWatery diarrheaGlucose levelsFecal fatDecrease diarrheaDiarrheaPatientsSomatostatinDiseaseInfusionSyndromeResectionBiliary tract abnormalities in patients with arteriohepatic dysplasia
Gorelick F, Dobbins J, Burrell M, Riely C. Biliary tract abnormalities in patients with arteriohepatic dysplasia. Digestive Diseases And Sciences 1982, 27: 815-820. PMID: 7105953, DOI: 10.1007/bf01391375.Peer-Reviewed Original ResearchConceptsEndoscopic retrograde cholangiopancreatogramBiliary tract abnormalitiesIntrahepatic ductsTract abnormalitiesArteriohepatic dysplasiaExtrahepatic biliary tract obstructionBiliary tract obstructionTract obstructionExtrahepatic ductsCongenital syndromePatientsFocal areasCholestasisDysplasiaSyndromeAbnormalitiesDuctLatter findingCholangiopancreatogramCirrhosisGallstonesDilatationObstructionSymptoms
1981
Ultrasonography of alcoholic liver disease with histological correlation.
Taylor KJ, Gorelick FS, Rosenfield AT, Riely CA. Ultrasonography of alcoholic liver disease with histological correlation. Radiology 1981, 141: 157-61. PMID: 6270725, DOI: 10.1148/radiology.141.1.6270725.Peer-Reviewed Original ResearchIs gastroduodenitis part of the spectrum of peptic ulcer disease?
DeLuca VA, Winnan GG, Sheahan DG, Sanders FJ, Greenlaw R, Marignani P, Gorelick FS, Bhalotra R, Goldblatt RS. Is gastroduodenitis part of the spectrum of peptic ulcer disease? Journal Of Clinical Gastroenterology 1981, 3: 17-22. PMID: 7320465.Peer-Reviewed Original ResearchConceptsPeptic ulcer diseaseUlcer diseasePeptic ulcerDifferent pathogenetic mechanismsSimilar clinical picturePreliminary dataAcute gastroduodenitisDuodenitis patientsGastrointestinal symptomsDuodenal ulcerUlcer craterAtypical manifestationsClinical pictureProspective studyGastric ulcerControl subjectsPathogenetic mechanismsHistologic studyTreatment responseBland dietGastroduodenitisPatientsProliferative indexThymidine uptakeUlcers