1993
A new quantitative method for the analysis of cardiac perfusion tomography (SPET): validation in post-infarct patients treated with thrombolytic therapy
Mortelmans L, Nuyts J, Scheys I, Wackers F, Lesaffre E, Brzostek T, De Roo M, De Geest H, Suetens P, Verbruggen A, Van de Werf F. A new quantitative method for the analysis of cardiac perfusion tomography (SPET): validation in post-infarct patients treated with thrombolytic therapy. European Journal Of Nuclear Medicine And Molecular Imaging 1993, 20: 1193-1200. PMID: 8299655, DOI: 10.1007/bf00171018.Peer-Reviewed Original ResearchConceptsEnzymatic infarct sizePerfusion defectsThrombolytic therapyVentricular functionInfarct sizeInfarct-related vesselLarge perfusion defectsThallium-201 chloridePost-infarct patientsPerfusion defect sizeGlobal ventricular functionRegional ventricular functionPerfusion tomographyContrast angiographyPatientsBeneficial effectsTherapyMyocardial perfusion tomogramsSignificant differencesPlanar quantificationValve planeImpact of regional ventricular function, geometry, and dobutamine stress on quantitative 99mTc-sestamibi defect size.
Sinusas AJ, Shi Q, Vitols PJ, Fetterman RC, Maniawski P, Zaret BL, Wackers FJ. Impact of regional ventricular function, geometry, and dobutamine stress on quantitative 99mTc-sestamibi defect size. Circulation 1993, 88: 2224-2234. PMID: 8222117, DOI: 10.1161/01.cir.88.5.2224.Peer-Reviewed Original ResearchConceptsHours of reperfusionDobutamine stressMyocardial thickeningVentricular geometryDefect magnitudeCoronary artery occlusionLeft ventricular geometryOpen-chest dogsRegional ventricular functionCircumferential profile analysisDefect sizeMIBI defectsArtery occlusionMyocardial salvageVentricular functionVentricular sizePharmacological stressNonviable myocardiumES imagesMyocardial perfusionInfarcted dogsRegional functionReperfusionRisk areasDogs
1989
Quantitative radionuclide assessment of regional ventricular function after thrombolytic therapy for acute myocardial infarction: Results of phase I Thrombolysis in Myocardial Infarction (TIMI) trial
Wackers F, Terrin M, Kayden D, Knatterud G, Forman S, Braunwald E, Zaret B, Investigators. Quantitative radionuclide assessment of regional ventricular function after thrombolytic therapy for acute myocardial infarction: Results of phase I Thrombolysis in Myocardial Infarction (TIMI) trial. Journal Of The American College Of Cardiology 1989, 13: 998-1005. PMID: 2494246, DOI: 10.1016/0735-1097(89)90250-7.Peer-Reviewed Original ResearchConceptsRecombinant tissue-type plasminogen activatorLeft ventricular ejection fractionInfarct-related arteryVentricular ejection fractionGlobal left ventricular ejection fractionRegional left ventricular functionLeft ventricular functionEjection fractionAcute myocardial infarctionRegional ejection fractionVentricular functionMyocardial infarctionMean global left ventricular ejection fractionIntravenous recombinant tissue-type plasminogen activatorRegional left ventricular ejection fractionEffect of thrombolysisMyocardial Infarction trialRegional ventricular functionTissue-type plasminogen activatorPatients 185Sustained reperfusionIntravenous streptokinaseAngiographic reperfusionThrombolytic therapyPatency rates