2004
Abnormal heart rate response to adenosine infusion is associated with silent myocardial ischemia in asymptomatic patients with diabetes mellitus
Sudhakar S, Chyun D, Young L, Inzucchi S, Davey J, Wackers F. Abnormal heart rate response to adenosine infusion is associated with silent myocardial ischemia in asymptomatic patients with diabetes mellitus. Journal Of Nuclear Cardiology 2004, 11: s20. DOI: 10.1016/j.nuclcard.2004.06.064.Peer-Reviewed Original ResearchHeart rate responseSilent myocardial ischemiaLarge myocardial perfusion defectsMyocardial perfusion defectsLarger perfusion abnormalityAsymptomatic patientsNegative predictive valuePerfusion abnormalitiesMyocardial ischemiaPerfusion defectsAdenosine infusionRate responsePredictive valueAbnormal heart rate responseBlunted heart rate responseHigh negative predictive valueLower heart rate responseCoronary artery diseaseMyocardial perfusion abnormalitiesDetection of ischemiaMales 53Autonomic neuropathyArtery diseaseDiabetes mellitusPoor outcome
1997
Relevance of Increased Lung Thallium Uptake on Stress Imaging in Patients With Unstable Angina and Non-Q Wave Myocardial Infarction: Results of the Thrombolysis in Myocardial Infarction (TIMI)-IIIB Study fn1fn1This study was supported in part by a research grant from Mallinckrodt Medical Inc., Saint Louis, Missouri.
Jain D, Thompson B, Wackers F, Zaret B, Investigators F. Relevance of Increased Lung Thallium Uptake on Stress Imaging in Patients With Unstable Angina and Non-Q Wave Myocardial Infarction: Results of the Thrombolysis in Myocardial Infarction (TIMI)-IIIB Study fn1fn1This study was supported in part by a research grant from Mallinckrodt Medical Inc., Saint Louis, Missouri. Journal Of The American College Of Cardiology 1997, 30: 421-429. PMID: 9247514, DOI: 10.1016/s0735-1097(97)00164-2.Peer-Reviewed Original ResearchConceptsLung/heart ratioAdverse cardiac eventsNon-Q-wave myocardial infarctionCoronary artery diseaseCardiac eventsPerfusion abnormalitiesMyocardial infarctionUnstable anginaArtery diseaseStress-induced left ventricular dysfunctionHigher cardiac event rateLeft ventricular ejection fractionAggressive interventional managementHigher revascularization rateLung thallium uptakeCardiac event rateTotal exercise timeFrequency of anginaLeft ventricular dysfunctionST-segment depressionLower exercise capacityVentricular ejection fractionPrevious myocardial infarctionMyocardial perfusion abnormalitiesNormal myocardial perfusion
1995
Myocardial perfusion imaging with 99mTc tetrofosmin. Comparison to 201Tl imaging and coronary angiography in a phase III multicenter trial. Tetrofosmin International Trial Study Group.
Zaret B, Rigo P, Wackers F, Hendel R, Braat S, Iskandrian A, Sridhara B, Jain D, Itti R, Serafini A, Goris M, Lahiri A. Myocardial perfusion imaging with 99mTc tetrofosmin. Comparison to 201Tl imaging and coronary angiography in a phase III multicenter trial. Tetrofosmin International Trial Study Group. Circulation 1995, 91: 313-9. PMID: 7805233, DOI: 10.1161/01.cir.91.2.313.Peer-Reviewed Original ResearchConceptsCoronary artery diseaseArtery diseaseTetrofosmin imagingCoronary angiographyMyocardial perfusionTetrofosmin imagesHealthy subjectsPhase III multicenter trialConventional myocardial perfusionLower likelihoodCentral core laboratoryMyocardial perfusion abnormalitiesNew 99mTcPeak heart rateNegative predictive accuracyMyocardial perfusion imagingNew myocardial imaging agentPlanar 201TlMulticenter trialNormalcy rateCoronary angiogramDouble productPerfusion abnormalitiesMyocardial imaging agentRadiotracer injection
1980
Thallium-201 Myocardial Imaging in Acute Myocardial Infarction
Wackers F, Lie K, Busemann Sokole E, Wellens H, Samson G, van der Schoot J. Thallium-201 Myocardial Imaging in Acute Myocardial Infarction. Developments In Cardiovascular Medicine 1980, 9: 117-160. DOI: 10.1007/978-94-009-8904-7_6.Peer-Reviewed Original ResearchAcute myocardial infarctionMyocardial infarctionThallium-201 myocardial imagingThallium-201 scintigraphyCoronary care unitMyocardial perfusion abnormalitiesLeft lateral viewIll patientsCare unitPerfusion abnormalitiesMobile gamma cameraMyocardial imagingPatientsInfarctionAnterior viewBed sideOblique viewScintigraphyEarly phaseGamma cameraSensitive techniqueAbnormalities