2011
Non-invasive imaging in acute chest pain syndromes
Sechtem U, Achenbach S, Friedrich M, Wackers F, Zamorano J. Non-invasive imaging in acute chest pain syndromes. European Heart Journal - Cardiovascular Imaging 2011, 13: 69-78. PMID: 22094238, DOI: 10.1093/ejechocard/jer250.Peer-Reviewed Original Research
2004
Randomized, Controlled Dose-Ranging Study of the Selective Adenosine A2A Receptor Agonist Binodenoson for Pharmacological Stress as an Adjunct to Myocardial Perfusion Imaging
Udelson J, Heller G, Wackers F, Chai A, Hinchman D, Coleman P, Dilsizian V, DiCarli M, Hachamovitch R, Johnson J, Barrett R, Gibbons R. Randomized, Controlled Dose-Ranging Study of the Selective Adenosine A2A Receptor Agonist Binodenoson for Pharmacological Stress as an Adjunct to Myocardial Perfusion Imaging. Circulation 2004, 109: 457-464. PMID: 14734517, DOI: 10.1161/01.cir.0000114523.03312.7d.Peer-Reviewed Original ResearchConceptsReversible perfusion defectsDose-related reductionAdenosine receptor stimulationSide effectsPharmacological stressPerfusion defectsReceptor stimulationFrequent side effectsSubjective side effectsDose-Ranging StudyMyocardial perfusion imagingAdenosine A2A receptorsSingle photon emissionChest painCoronary vasodilationCrossover trialBinodenosonA2A receptorsPerfusion imagingSelective agonismRandom orderSeverityKappa valuesSimilar degreePhoton emissionEmergency Department Chest-Pain Center Imaging
Wackers F, Bruni W, Zaret B. Emergency Department Chest-Pain Center Imaging. Contemporary Cardiology 2004, 275-280. DOI: 10.1007/978-1-59259-426-9_19.Peer-Reviewed Original Research
2003
Use of radionuclide imaging in acute coronary syndromes
Abbott B, Wackers F. Use of radionuclide imaging in acute coronary syndromes. Current Cardiology Reports 2003, 5: 25-31. PMID: 12493157, DOI: 10.1007/s11886-003-0034-z.Peer-Reviewed Original ResearchConceptsAcute coronary syndromeMyocardial infarctionChest painCoronary syndromeEmergency departmentPerfusion imagingRadionuclide myocardial perfusion imagingAcute chest painTriage of patientsAcute myocardial infarctionPerfusion imaging studyMyocardial perfusion imagingNegative predictive valueReperfusion therapyED evaluationRoutine careRandomized trialsRisk stratificationInfarct sizePrognostic valueDiagnostic challengeUnnecessary hospitalizationPredictive valueTesting modalitiesImaging studies
2001
Selective use of single-photon emission computed tomography myocardial perfusion imaging in a chest pain center
Abbott B, Abdel-Aziz I, Nagula S, Monico E, Schriver J, Wackers F. Selective use of single-photon emission computed tomography myocardial perfusion imaging in a chest pain center. The American Journal Of Cardiology 2001, 87: 1351-1355. PMID: 11397352, DOI: 10.1016/s0002-9149(01)01551-x.Peer-Reviewed Original ResearchConceptsChest pain centerChest pain patientsCoronary artery diseasePain patientsSingle photon emissionChest painPain centerArtery diseaseMyocardial infarctionEmergency department chest pain centersEmergency department chest pain patientsTomography myocardial perfusion imagingTomography myocardial perfusionAcute myocardial infarctionMyocardial perfusion imagingSelective useCPC patientsNonischemic electrocardiogramHospital dischargeAppropriate patientsHospital admissionFinal diagnosisMyocardial perfusionPatientsPerfusion imaging9.2 Stress SPECT myocardial perfusion imaging optimizes the triage of emergency department patients with acute chest pain
ABBOTT B, ABDELAZIZ I, NAGULA S, WACKERS F. 9.2 Stress SPECT myocardial perfusion imaging optimizes the triage of emergency department patients with acute chest pain. Journal Of Nuclear Cardiology 2001, 8: s58-s58. DOI: 10.1016/s1071-3581(01)80643-7.Peer-Reviewed Original Research
2000
An economic analysis of an aggressive diagnostic strategy with single photon emission computed tomography myocardial perfusion imaging and early exercise stress testing in emergency department patients who present with chest pain but nondiagnostic electrocardiograms: Results from a randomized trial
Stowers S, Eisenstein E, Wackers F, Berman D, Blackshear J, Jones A, Szymanski T, Lam L, Simons T, Natale D, Paige K, Wagner G. An economic analysis of an aggressive diagnostic strategy with single photon emission computed tomography myocardial perfusion imaging and early exercise stress testing in emergency department patients who present with chest pain but nondiagnostic electrocardiograms: Results from a randomized trial. Annals Of Emergency Medicine 2000, 35: 17-25. PMID: 28140201, DOI: 10.1016/s0196-0644(00)70100-4.Peer-Reviewed Original ResearchMeSH KeywordsAgedChest PainClinical ProtocolsCoronary AngiographyCost ControlElectrocardiographyEmergency TreatmentExercise TestFemaleHospital CostsHumansLength of StayMaleMedicareMiddle AgedMyocardial InfarctionReproducibility of ResultsRisk FactorsSingle-Blind MethodTomography, Emission-Computed, Single-PhotonUnited StatesConceptsEarly exercise stress testingExercise stress testingLength of stayChest painHospital costsSingle photon emissionCoronary angiographyStress testingDiagnostic strategiesTomography myocardial perfusion imagingCost/charge ratiosAggressive diagnostic strategyNegative scan resultsPositive scan resultsAcute chest painIntermediate-risk patientsAcute coronary syndromeExercise treadmill testingAdverse clinical outcomesShorter median lengthEmergency department patientsAcute myocardial infarctionScan resultsMyocardial perfusion imagingPhoton emission
1998
Clinical Value of Acute Rest Technetium-99m Tetrofosmin Tomographic Myocardial Perfusion Imaging in Patients With Acute Chest Pain and Nondiagnostic Electrocardiograms
Heller G, Stowers S, Hendel R, Herman S, Daher E, Ahlberg A, Baron J, de Leon C, Rizzo J, Wackers F. Clinical Value of Acute Rest Technetium-99m Tetrofosmin Tomographic Myocardial Perfusion Imaging in Patients With Acute Chest Pain and Nondiagnostic Electrocardiograms. Journal Of The American College Of Cardiology 1998, 31: 1011-1017. PMID: 9562001, DOI: 10.1016/s0735-1097(98)00057-6.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionTomographic myocardial perfusionMyocardial infarctionChest painNondiagnostic electrocardiogramEmergency departmentHospital periodHospital admissionRest technetiumTetrofosmin SPECTMyocardial perfusionLow cardiac event rateTetrofosmin single photon emissionMultiple logistic regression analysisAcute chest painCardiac event rateNormal SPECT imagesMean cost savingsUnnecessary hospital admissionsLogistic regression analysisSingle photon emissionSPECT imagesAbnormal SPECTCardiac eventsRest Tc
1997
Prognostic value of normal rest tetrofosmin spect in patients with acute chest pain and nondiagnostic ECG in emergency department
Wackers F, Heller G, Stowers S, Hendel R, Herman S, Baron J, Daher E. Prognostic value of normal rest tetrofosmin spect in patients with acute chest pain and nondiagnostic ECG in emergency department. Journal Of Nuclear Cardiology 1997, 4: s26. DOI: 10.1016/s1071-3581(97)91217-4.Peer-Reviewed Original Research
1990
Thrombolytic therapy for myocardial infarction: Assessment of efficacy by myocardial perfusion imaging with technetium-99m sestamibi
Wackers F. Thrombolytic therapy for myocardial infarction: Assessment of efficacy by myocardial perfusion imaging with technetium-99m sestamibi. The American Journal Of Cardiology 1990, 66: e36-e41. PMID: 2145744, DOI: 10.1016/0002-9149(90)90610-d.Peer-Reviewed Original ResearchConceptsRecombinant tissue-type plasminogen activatorThrombolytic therapyMyocardial infarctionFirst acute myocardial infarctionInfarct-related artery patencyInitial risk areaPersistent coronary occlusionAcute chest painAcute myocardial infarctionAssessment of efficacyFuture clinical researchImaging agentNew thrombolytic agentsTissue-type plasminogen activatorArtery patencyChest painInfarct arterySuccessful thrombolysisConventional therapyCoronary occlusionHypoperfused myocardiumThrombolytic agentsMyocardial perfusionPatientsEnd pointSilent left ventricular dysfunction during routine activity after thrombolytic Therapy for acute myocardial infarction
Kayden D, Wackers F, Zaret B. Silent left ventricular dysfunction during routine activity after thrombolytic Therapy for acute myocardial infarction. Journal Of The American College Of Cardiology 1990, 15: 1500-1507. PMID: 2345230, DOI: 10.1016/0735-1097(90)92817-l.Peer-Reviewed Original ResearchConceptsTransient left ventricular dysfunctionLeft ventricular dysfunctionSilent left ventricular dysfunctionVentricular dysfunctionMyocardial infarctionCardiac eventsHospital dischargeEjection fractionThrombolytic therapySubmaximal supine bicycle exerciseNormal activityBaseline ejection fractionExercise test resultsSubsequent cardiac eventsSupine bicycle exerciseVentricular function monitoringAcute myocardial infarctionChest painPeak exerciseBicycle exerciseAmbulatory patientsElectrocardiographic changesPoor outcomePrognostic informationFunction monitoring
1989
Serial quantitative planar technetium-99m isonitrile imaging in acute myocardial infarction: Efficacy for noninvasive assessment of thrombolytic therapy
Wackers F, Gibbons R, Verani M, Kayden D, Pellikka P, Behrenbeck T, Mahmarian J, Zaret B. Serial quantitative planar technetium-99m isonitrile imaging in acute myocardial infarction: Efficacy for noninvasive assessment of thrombolytic therapy. Journal Of The American College Of Cardiology 1989, 14: 861-873. PMID: 2507612, DOI: 10.1016/0735-1097(89)90456-7.Peer-Reviewed Original ResearchConceptsRecombinant tissue-type plasminogen activatorAcute myocardial infarctionPatent infarct-related arteryInfarct-related arteryThallium-201 imagingThrombolytic therapyMyocardial infarctionPlanar technetiumMyocardial perfusionExercise thallium-201 imagingFirst acute myocardial infarctionInfarct-related artery patencyInitial risk areaPersistent coronary occlusionSuccess of reperfusionMyocardial blood flowNew myocardial perfusionTissue-type plasminogen activatorArtery patencyChest painCoronary occlusionRepeat imagingBlood flowInfarctionThallium-201Transient left ventricular dysfunction during provocative mental stress in patients with coronary artery disease
LaVeau P, Rozanski A, Krantz D, Cornell C, Cattanach L, Zaret B, Wackers F. Transient left ventricular dysfunction during provocative mental stress in patients with coronary artery disease. American Heart Journal 1989, 118: 1-8. PMID: 2741776, DOI: 10.1016/0002-8703(89)90064-1.Peer-Reviewed Original ResearchConceptsLeft ventricular ejection fractionCoronary artery diseaseCoronary diseaseMental stressArtery diseaseNormal volunteersPsychological stressVentricular ejection fractionStress-induced abnormalitiesLVEF responseChest painVentricular dysfunctionEjection fractionDouble productECG changesTransient ischemiaAcute decreaseBaseline valuesNormal subjectsStroop Color-Word TestPatientsPhysical exerciseAmbulatory monitoringImmediate reboundColor-Word Test
1987
Usefulness of residual ischemic myocardium within prior infarct zone for identifying patients at high risk late after acute myocardial infarction
Brown K, Weiss R, Clements J, Wackers F. Usefulness of residual ischemic myocardium within prior infarct zone for identifying patients at high risk late after acute myocardial infarction. The American Journal Of Cardiology 1987, 60: 15-19. PMID: 3604929, DOI: 10.1016/0002-9149(87)90975-1.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionTI-201 redistributionCardiac eventsInfarct zoneMyocardial infarctionStepwise multivariate logistic regression analysisPrior acute myocardial infarctionAngiographic coronary artery diseaseMultivariate logistic regression analysisIschemic viable myocardiumResidual ischemic myocardiumTotal cardiac eventsCoronary artery diseaseThallium-201 imagingSignificant predictorsLogistic regression analysisOnly significant predictorCoronary revascularizationChest painArtery diseaseCardiac catheterizationConsecutive patientsPrognostic implicationsViable myocardiumIschemic myocardium
1985
Prognostic significance of normal quantitative planar thallium-201 stress scintigraphy in patients with chest pain
Wackers F, Russo D, Russo D, Clements J. Prognostic significance of normal quantitative planar thallium-201 stress scintigraphy in patients with chest pain. Journal Of The American College Of Cardiology 1985, 6: 27-30. PMID: 3159779, DOI: 10.1016/s0735-1097(85)80247-3.Peer-Reviewed Original ResearchConceptsCoronary artery diseaseThallium-201 stress scintigraphyArtery diseaseStress scintigraphyPretest likelihoodCardiac eventsChest painPrognostic significanceQuantitative thallium-201 scintigraphyChest pain syndromeThallium-201 scintigraphyHigh pretest likelihoodLow pretest likelihoodBasis of symptomsAnginal complaintsMean followPain syndromeExcellent prognosisNormal findingsConsecutive seriesStress electrocardiographyNormal studiesPatientsScintigraphyDisease
1983
Aneurysm of the Pulmonary Artery as a Cause of Severe Chest Pain
Jaffin B, Gundel W, Capeless M, Castaneda A, Rabinovitch M, Wackers F. Aneurysm of the Pulmonary Artery as a Cause of Severe Chest Pain. JAMA Internal Medicine 1983, 143: 1484-1485. PMID: 6870423, DOI: 10.1001/archinte.1983.00350070212037.Peer-Reviewed Original ResearchConceptsSevere chest painPulmonary arteryChest painNormal pulmonary artery pressureContiguous mediastinal structuresPrecordial chest painPulmonary artery aneurysmPulmonary artery pressureRelief of symptomsSerial chest roentgenogramsEvidence of ruptureArtery pressureChest roentgenogramAneurysmal dilatationArtery aneurysmEmergency roomAbsence of rupturePain receptorsInitial symptomsMediastinal structuresSuch painPainArteryTen-year periodAneurysms
1981
Imaging the inflammatory response to acute myocardial infarction in man using indium-111-labeled autologous platelets.
Davies R, Thakur M, Berger H, Wackers F, Gottschalk A, Zaret B. Imaging the inflammatory response to acute myocardial infarction in man using indium-111-labeled autologous platelets. Circulation 1981, 63: 826-832. PMID: 7471338, DOI: 10.1161/01.cir.63.4.826.Peer-Reviewed Original ResearchConceptsMyocardial infarctionInflammatory responseIndium-111-labeled autologous plateletsMembrane-active antiarrhythmic drugsPeak serum creatine kinaseStable coronary artery diseaseAcute transmural myocardial infarctionPeripheral leukocyte countCoronary artery diseaseAcute myocardial infarctionHours of infarctionTransmural myocardial infarctionIncidence of pericarditisLocation of infarctionIndium-111 leukocytesSerum creatine kinaseChest painArtery diseaseAntiarrhythmic drugsAcute infarctionAutologous leukocytesLeukocyte countAntiinflammatory drugsAutologous plateletsInfarctionExercise left ventricular performance in patients with chest pain, ischemic-appearing exercise electrocardiograms, and angiographically normal coronary arteries.
Berger HJ, Sands MJ, Davies RA, Wackers FJ, Alexander J, Lachman AS, Williams BW, Zaret BL. Exercise left ventricular performance in patients with chest pain, ischemic-appearing exercise electrocardiograms, and angiographically normal coronary arteries. Annals Of Internal Medicine 1981, 94: 186-91. PMID: 7469209, DOI: 10.7326/0003-4819-94-2-186.Peer-Reviewed Original ResearchConceptsNormal coronary arteriesLeft ventricular performanceChest painVentricular performanceCoronary arteryExercise electrocardiogramAbnormal ejection fraction responseMaximal upright bicycle exerciseCoronary arterial spasmUpright bicycle exerciseEjection fraction responseFirst-pass radionuclide angiocardiographyThallium-201 imagingErgonovine testingVentricular dysfunctionArterial spasmBicycle exerciseErgonovine provocationAdditional patientsTreadmill exercisePerfusion defectsRadionuclide angiocardiographyRegional dysfunctionPatientsFraction response
1980
Thallium-201 myocardial scintigraphy in acute myocardial infarction and ischemia
Wackers F. Thallium-201 myocardial scintigraphy in acute myocardial infarction and ischemia. Seminars In Nuclear Medicine 1980, 10: 127-145. PMID: 7394537, DOI: 10.1016/s0001-2998(80)80016-x.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionMyocardial infarctionPerfusion defectsThallium-201 myocardial scintigraphyThallium-201 scintigraphyOnset of symptomsResults of scintigraphyChest painUnstable anginaJeopardized myocardiumMyocardial scintigraphyPrognostic stratificationEarly recognitionHigh riskInfarctionPatientsScintigraphyIschemiaHrAnginaComplicationsPainReliable methodMyocardial Imaging with Thallium-201 and Technetium-99m-Pyrophosphate in the Coronary Care Unit: Conclusion
Wackers F, Willerson J. Myocardial Imaging with Thallium-201 and Technetium-99m-Pyrophosphate in the Coronary Care Unit: Conclusion. Developments In Cardiovascular Medicine 1980, 9: 241-244. DOI: 10.1007/978-94-009-8904-7_14.Peer-Reviewed Original ResearchAcute myocardial infarctionMyocardial infarctionMyocar-dial infarctionAcute chest painCoronary care unitChest painCare unitClinical recognitionTechnetium-99mPatient historyThallium-201Myocardial imagingSerum enzymesInfarctionPatientsImaging techniquesSuccessful visualizationFirst reportMultiple reasonsPainMyocardiumDiagnosis