2022
Urine Uromodulin as a Biomarker of Kidney Tubulointerstitial Fibrosis
Melchinger H, Calderon-Gutierrez F, Obeid W, Xu L, Shaw MM, Luciano RL, Kuperman M, Moeckel GW, Kashgarian M, Wilson FP, Parikh CR, Moledina DG. Urine Uromodulin as a Biomarker of Kidney Tubulointerstitial Fibrosis. Clinical Journal Of The American Society Of Nephrology 2022, 17: 1284-1292. PMID: 35948365, PMCID: PMC9625093, DOI: 10.2215/cjn.04360422.Peer-Reviewed Original ResearchMeSH KeywordsAlbuminsAnimalsAtrophyBiomarkersCreatinineFibrosisHumansKidneyKidney DiseasesMiceUromodulinConceptsInterstitial fibrosis/tubular atrophyUrine uromodulinTubular atrophyThick ascending limbUrine albuminSerum creatinineKidney biopsyTubulointerstitial fibrosisMultivariable linear regression modelsTime of biopsyKidney's thick ascending limbAcademic medical centerHuman kidney biopsiesKidney tubulointerstitial fibrosisTubular healthMultivariable analysisHistologic featuresHistologic findingsHistologic changesKidney fibrosisIndependent associationFibrotic modelMultivariable modelMedical CenterMurine model
2013
Cdc42 Deficiency Causes Ciliary Abnormalities and Cystic Kidneys
Choi SY, Chacon-Heszele MF, Huang L, McKenna S, Wilson FP, Zuo X, Lipschutz JH. Cdc42 Deficiency Causes Ciliary Abnormalities and Cystic Kidneys. Journal Of The American Society Of Nephrology 2013, 24: 1435-1450. PMID: 23766535, PMCID: PMC3752951, DOI: 10.1681/asn.2012121236.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsApoptosisCdc42 GTP-Binding ProteinCell ProliferationCiliaDisease Models, AnimalFibrosisIn Vitro TechniquesKidney Diseases, CysticKidney Tubules, CollectingKidney Tubules, DistalMiceMice, KnockoutMice, TransgenicMitogen-Activated Protein Kinase KinasesPhenotypeSignal TransductionVesicular Transport ProteinsZebrafishZebrafish ProteinsConceptsCiliary proteinsSynergistic genetic interactionMitogen-activated protein kinase activationSmall GTPase Cdc42Role of Cdc42Protein kinase activationKnockdown of Cdc42Trafficking complexGTPase Cdc42Genetic interactionsSec10 knockdownPolycystic kidney diseaseCyst cellsCdc42 knockdownPrimary ciliaPhotoreceptor ciliaCdc42Kinase activationExocystMAPK activationCiliogenesisSec10Same pathwayPathways resultsCdc42 deficiency