2023
Genome-wide Association Study for AKI
Bhatraju P, Stanaway I, Palmer M, Menon R, Schaub J, Menez S, Srivastava A, Wilson F, Kiryluk K, Palevsky P, Naik A, Sakr S, Jarvik G, Parikh C, Ware L, Ikizler T, Siew E, Chinchilli V, Coca S, Garg A, Go A, Kaufman J, Kimmel P, Himmelfarb J, Wurfel M. Genome-wide Association Study for AKI. Kidney360 2023, 4: 870-880. PMID: 37273234, PMCID: PMC10371295, DOI: 10.34067/kid.0000000000000175.Peer-Reviewed Original ResearchConceptsGenome-wide association studiesGene locusAssociation studiesSingle-cell RNA sequencing dataHealthy living donorsLoop of HenleThick ascending limbWide significant associationsGenetic variantsGenome-wide significanceRNA sequencing dataKidney biopsyCommon genetic riskLiving donorsSubsequent sequelaeSerial evaluationFunctional annotationIntergenic regionAscending limbGene expressionSequencing dataRisk of AKIKidney biopsy tissueProximal tubular epithelial cellsMember 1 gene
2022
Urine Uromodulin as a Biomarker of Kidney Tubulointerstitial Fibrosis
Melchinger H, Calderon-Gutierrez F, Obeid W, Xu L, Shaw MM, Luciano RL, Kuperman M, Moeckel GW, Kashgarian M, Wilson FP, Parikh CR, Moledina DG. Urine Uromodulin as a Biomarker of Kidney Tubulointerstitial Fibrosis. Clinical Journal Of The American Society Of Nephrology 2022, 17: 1284-1292. PMID: 35948365, PMCID: PMC9625093, DOI: 10.2215/cjn.04360422.Peer-Reviewed Original ResearchConceptsInterstitial fibrosis/tubular atrophyUrine uromodulinTubular atrophyThick ascending limbUrine albuminSerum creatinineKidney biopsyTubulointerstitial fibrosisMultivariable linear regression modelsTime of biopsyKidney's thick ascending limbAcademic medical centerHuman kidney biopsiesKidney tubulointerstitial fibrosisTubular healthMultivariable analysisHistologic featuresHistologic findingsHistologic changesKidney fibrosisIndependent associationFibrotic modelMultivariable modelMedical CenterMurine model