2022
Optimizing the Design and Analysis of Future AKI Trials
Legrand M, Bagshaw SM, Koyner JL, Schulman IH, Mathis MR, Bernholz J, Coca S, Gallagher M, Gaudry S, Liu KD, Mehta RL, Pirracchio R, Ryan A, Steubl D, Stockbridge N, Erlandsson F, Turan A, Wilson FP, Zarbock A, Bokoch MP, Casey JD, Rossignol P, Harhay MO. Optimizing the Design and Analysis of Future AKI Trials. Journal Of The American Society Of Nephrology 2022, 33: 1459-1470. PMID: 35831022, PMCID: PMC9342638, DOI: 10.1681/asn.2021121605.Peer-Reviewed Original ResearchConceptsAKI trialsClinical trialsTrial participantsTrial designAKI clinical trialsPerioperative patient populationsComplex clinical syndromeRisk of morbidityPragmatic trial designTreatment effectsClinical trial planningImportant treatment effectsClinical trial analysisAKI preventionClinical courseClinical syndromePatient populationTrial interventionClinical questionsClinical trialistsAKITrial infrastructureTrial planningTrialsEfficient enrollment
2021
REVeAL-HF Design and Rationale of a Pragmatic Randomized Controlled Trial Embedded Within Routine Clinical Practice
Ahmad T, Yamamoto Y, Biswas A, Ghazi L, Martin M, Simonov M, Hsiao A, Kashyap N, Velazquez EJ, Desai NR, Wilson FP. REVeAL-HF Design and Rationale of a Pragmatic Randomized Controlled Trial Embedded Within Routine Clinical Practice. JACC Heart Failure 2021, 9: 409-419. PMID: 33992566, DOI: 10.1016/j.jchf.2021.03.006.Peer-Reviewed Original ResearchConceptsHeart failurePatient outcomesClinical decision makingN-terminal pro-B-type natriuretic peptide levelsPro-B-type natriuretic peptide levelsPragmatic Randomized Controlled TrialIntravenous diuretic agentsNatriuretic peptide levelsRandomized Controlled TrialsRoutine clinical practiceEvidence-based interventionsElectronic health recordsControlled TrialsPatient populationAccurate prognosticationCommon causeDiuretic agentsPeptide levelsClinical practicePg/TrialsHealth recordsSignificant riskMortalityOutcomes
2012
Creatinine generation is reduced in patients requiring continuous venovenous hemodialysis and independently predicts mortality
Wilson FP, Sheehan JM, Mariani LH, Berns JS. Creatinine generation is reduced in patients requiring continuous venovenous hemodialysis and independently predicts mortality. Nephrology Dialysis Transplantation 2012, 27: 4088-4094. PMID: 22273668, PMCID: PMC3529547, DOI: 10.1093/ndt/gfr809.Peer-Reviewed Original ResearchConceptsAcute kidney injuryCreatinine generation rateContinuous venovenous hemodialysisSeverity of AKISerum creatinine concentrationCreatinine concentrationHospital mortalityTertiary care hospital settingSerum creatinine increaseGlomerular filtration rateLength of hospitalizationMeasures of severityAKI severityCreatinine increaseKidney injuryHospital dischargeMultivariable adjustmentSerum creatinineCohort studyMultivariable analysisPatient populationUnadjusted analysesCreatinine generationFiltration rateOncologic diagnosis