2023
Identification and validation of urinary CXCL9 as a biomarker for diagnosis of acute interstitial nephritis
Moledina D, Obeid W, Smith R, Rosales I, Sise M, Moeckel G, Kashgarian M, Kuperman M, Campbell K, Lefferts S, Meliambro K, Bitzer M, Perazella M, Luciano R, Pober J, Cantley L, Colvin R, Wilson F, Parikh C. Identification and validation of urinary CXCL9 as a biomarker for diagnosis of acute interstitial nephritis. Journal Of Clinical Investigation 2023, 133: e168950. PMID: 37395276, PMCID: PMC10313360, DOI: 10.1172/jci168950.Peer-Reviewed Original ResearchConceptsUrinary CXCL9External validation cohortValidation cohortControl groupAIN diagnosisDiscovery cohortKidney tissueDiagnostic biomarkersAcute interstitial nephritisCXCL9 mRNA expressionAcute kidney injuryBiopsy-confirmed diagnosisAvailable clinical testsNational InstituteKidney injuryTubulointerstitial nephritisInterstitial nephritisKidney biopsyHistological confirmationHistological diagnosisTreatment optionsLymphocyte chemotaxisCXCL9MRNA expression differencesPatients
2017
A Survey of Patient Attitudes Toward Participation in Biopsy-Based Kidney Research
Moledina DG, Cheung B, Kukova L, Luciano RL, Peixoto AJ, Wilson FP, Alfano S, Parikh CR. A Survey of Patient Attitudes Toward Participation in Biopsy-Based Kidney Research. Kidney International Reports 2017, 3: 412-416. PMID: 29725645, PMCID: PMC5932306, DOI: 10.1016/j.ekir.2017.11.008.Peer-Reviewed Original ResearchAdditional needle passesKidney tissueKidney biopsyKidney diseasePatients' attitudesNeedle passesHealth/National InstituteMultivariable logistic modelNational InstituteNovel therapeutic targetHuman kidney tissueBiopsy complicationsAfrican American participantsLower oddsBiopsyTherapeutic targetPrecision Medicine InitiativePatientsMedicine InitiativeTissueDiseaseKidney researchParticipantsAdditional burdenTotal