Featured Publications
Real-Time Prediction of Acute Kidney Injury in Hospitalized Adults: Implementation and Proof of Concept
Ugwuowo U, Yamamoto Y, Arora T, Saran I, Partridge C, Biswas A, Martin M, Moledina DG, Greenberg JH, Simonov M, Mansour SG, Vela R, Testani JM, Rao V, Rentfro K, Obeid W, Parikh CR, Wilson FP. Real-Time Prediction of Acute Kidney Injury in Hospitalized Adults: Implementation and Proof of Concept. American Journal Of Kidney Diseases 2020, 76: 806-814.e1. PMID: 32505812, PMCID: PMC8667815, DOI: 10.1053/j.ajkd.2020.05.003.Peer-Reviewed Original ResearchConceptsAKI alertsHospitalized adultsKidney injuryUrban tertiary care hospitalAcute kidney injurySerum creatinine levelsObservational cohort studyTertiary care hospitalSerum creatinine concentrationBeats/minElectronic health recordsAKI diagnosisCohort studyCreatinine levelsInpatient mortalitySystolic bloodFractional excretionCenter studyBlood biomarkersUnivariable associationsUrine microscopyCreatinine concentrationClinical careElevated riskUrea nitrogenPersonalised recommendations for hospitalised patients with Acute Kidney Injury using a Kidney Action Team (KAT-AKI): protocol and early data of a randomised controlled trial
Aklilu A, O’Connor K, Martin M, Yamamoto Y, Coronel-Moreno C, Shvets K, Jones C, Kadhim B, Corona-Villalobos C, Baker M, Tan J, Freeman N, Groener M, Menez S, Brown D, Culli S, Lindsley J, Orias M, Parikh C, Smith A, Sundararajan A, Wilson F. Personalised recommendations for hospitalised patients with Acute Kidney Injury using a Kidney Action Team (KAT-AKI): protocol and early data of a randomised controlled trial. BMJ Open 2023, 13: e071968. PMID: 37068906, PMCID: PMC10111926, DOI: 10.1136/bmjopen-2023-071968.Peer-Reviewed Original ResearchConceptsPrimary teamAcute Kidney Injury OutcomesAKI alert systemInvestigator-blinded trialUsual care armKey secondary outcomesClinical decision support toolIntensive care unitUS hospital systemAKI alertsAKI detectionAKI progressionCare armSecondary outcomesPrimary outcomeCare unitMedian timeMedical floorPercentage of recommendationsDiagnostic interventionsInjury outcomesRandomisationHospital systemEthics CommitteeDedicated team
2021
AACC Guidance Document on Laboratory Investigation of Acute Kidney Injury
El-Khoury JM, Hoenig MP, Jones GRD, Lamb EJ, Parikh CR, Tolan NV, Wilson FP. AACC Guidance Document on Laboratory Investigation of Acute Kidney Injury. The Journal Of Applied Laboratory Medicine 2021, 6: 1316-1337. PMID: 33973621, DOI: 10.1093/jalm/jfab020.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsAcute kidney injuryKidney injuryNew biomarkersPotential acute kidney injuryInsulin-like growth factor binding protein 7Growth factor binding protein 7Early detectionLong-term complicationsLaboratory investigationsEmergence of biomarkersHealth care costsBinding protein 7AKI alertsKidney damageClinical indicationsCystatin CSudden episodeCare costsTissue inhibitorDiagnostic thresholdMetalloproteinases 2Test utilizationPreponderance of evidenceTraditional markersExpert recommendations
2019
Electronic Alerts for Acute Kidney Injury Amelioration (ELAIA-1): a completely electronic, multicentre, randomised controlled trial: design and rationale
Mutter M, Martin M, Yamamoto Y, Biswas A, Etropolski B, Feldman H, Garg A, Gourlie N, Latham S, Lin H, Palevsky PM, Parikh C, Moreira E, Ugwuowo U, Wilson FP. Electronic Alerts for Acute Kidney Injury Amelioration (ELAIA-1): a completely electronic, multicentre, randomised controlled trial: design and rationale. BMJ Open 2019, 9: e025117. PMID: 31154298, PMCID: PMC6549649, DOI: 10.1136/bmjopen-2018-025117.Peer-Reviewed Original ResearchConceptsAcute kidney injuryElectronic alertsMedical intensive care unitYale-New Haven HospitalDays of randomisationIntensive care unitElectronic alert systemNew Haven HospitalAppropriate ethics committeeElectronic medical record systemAKI alertsAKI progressionAlert specificityInpatient dialysisKidney injuryHospitalised patientsPeer-reviewed journalsUsual careInpatient deathMedical record systemPrimary outcomeCare unitExclusion criteriaOrder setsInformed consent
2018
Utility of Electronic Medical Record Alerts to Prevent Drug Nephrotoxicity
Martin M, Wilson FP. Utility of Electronic Medical Record Alerts to Prevent Drug Nephrotoxicity. Clinical Journal Of The American Society Of Nephrology 2018, 14: 115-123. PMID: 29622668, PMCID: PMC6364537, DOI: 10.2215/cjn.13841217.Commentaries, Editorials and LettersConceptsElectronic medical record alertsAppropriate drug dosingRisk of AKIAKI alertsDrug nephrotoxicityInappropriate prescribingPrompt recognitionClinical outcomesIatrogenic formDrug dosingPatient benefitAKIPrescribers' actionsOff-target effectsPatientsSuch alertsMethods of evaluationNephrotoxicityPrescribingDosingNephrotoxins
2016
Provider acceptance of an automated electronic alert for acute kidney injury
Oh J, Bia JR, Ubaid-Ullah M, Testani JM, Wilson FP. Provider acceptance of an automated electronic alert for acute kidney injury. Clinical Kidney Journal 2016, 9: 567-571. PMID: 27478598, PMCID: PMC4957729, DOI: 10.1093/ckj/sfw054.Peer-Reviewed Original ResearchAcute kidney injuryElectronic alertsAKI alertsKidney injuryPatient careAKI alert systemElectronic AKI alertsNon-physician providersPercent of respondersHealthcare provider opinionsElectronic medical recordsClinical decision support systemMedical recordsSingle hospitalProviders' opinionsProvider acceptanceTrial durationPaucity of informationPatient-specific informationTrialsSignificant differencesAlert trialsInjuryApprovalCare